Catalog Number: 1264
Chemical Name: 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
Biological Activity
A highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively). Promotes stability of naive human pluripotent stem cells in culture. Also available as part of the MAPK Inhibitor Tocriset™.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    Davies et al.
    Biochem.J., 2000;351:95
  2. The activation of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding.
    Frantz et al.
    Biochemistry, 1998;37:13846
  3. Characterization of the structure and function of a new mitogen-activated protein kinase (p38β).
    Jiang et al.
    J.Biol.Chem., 1996;271:17920
  4. Induction of apoptosis by SB 202190 through inhibition of p38β mitogen-activated protein kinase.
    Nemoto et al.
    J.Biol.Chem., 1998;273:16415
  5. Derivation of novel human ground state naive pluripotent stem cells.
    Gafni et al.
    Nature, 2013;504:282

The citations listed below are publications that use Tocris products. Selected citations for SB 202190 include:

19 Citations: Showing 1 - 10
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  1. IL-17A causes depression-like symptoms via NFκB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression.
    Authors: Nadeem
    Cytokine 2017;97:14
  2. Excess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia.
    Authors: Zhang Et al.
    PLoS One 2015;5:16548
  3. The role of Na+/K+-ATPase during chick skeletal myogenesis.
    Authors: Oliveira Et al.
    J Neurosci 2015;10:e0120940
  4. Modulation of radiation injury response in retinal endothelial cells by quinic acid derivative KZ-41 involves p38 MAPK.
    Authors: Toutounchian Et al.
    PLoS One 2014;9:e100210
  5. TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    Authors: Babu Et al.
    BMC Cancer 2014;14:113
  6. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
    Authors: Kleinewietfeld Et al.
    Sci Rep 2013;496:518
  7. 3,3'-diindolylmethane rapidly and selectively inhibits hepatocyte growth factor/c-Met signaling in breast cancer cells.
    Authors: Nicastro Et al.
    J Nutr Biochem 2013;24:1882
  8. Identification of repurposed small molecule drugs for chordoma therapy.
    Authors: Xia Et al.
    Cancer Biol Ther 2013;14:638
  9. Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide.
    Authors: Shaw and Lloyd
    Nature 2012;84:155
  10. Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis.
    Authors: Akhmetshina Et al.
    J Biol Chem 2012;3:735
  11. BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells.
    Authors: Zhu Et al.
    Am J Physiol Lung Cell Mol Physiol 2012;31:31
  12. Transforming growth factor-β2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling.
    Authors: Medici Et al.
    J Exp Clin Cancer Res 2011;437:515
  13. Dermatophagoides pteronyssinus 2 regulates nerve growth factor release to induce airway inflammation via a reactive oxygen species-dependent pathway.
    Authors: Ye Et al.
    Am J Physiol Regul Integr Comp Physiol 2011;300:L216
  14. Dual specificity phosphatase 1 regulates human inducible nitric oxide synthase expression by p38 MAP kinase.
    Authors: Turpeinen Et al.
    J Neurosci 2011;2011:127587
  15. Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing.
    Authors: Riedl Et al.
    Nat Commun 2009;29:13377
  16. Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA.
    Authors: Guillemot and Citi
    Mol Biol Cell 2006;17:3569
  17. Oxygen-sensitive {δ}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection.
    Authors: Ma Et al.
    Mediators Inflamm 2005;280:16208
  18. Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1.
    Authors: Gallagher Et al.
    Biochem J 2004;24:4859
  19. Calcineurin-independent inhibition of mitochondrial Ca2+ uptake by cyclosporin A.
    Authors: Montero Et al.
    Br J Pharmacol 2004;141:263
Expand to show all 19 Citations

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