STIM-Orai Channel Inhibitors

STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). SOCE allows rapid Ca²⁺ efflux from the endoplasmic reticulum (ER), following the emptying of intracellular Ca²⁺ stores.

STIM (stromal interaction molecule) proteins, STIM1 and STIM2, serve as ER Ca²⁺ sensors. They contain N'-terminal Ca²⁺-sensing EF-hand domains and are localized to the tubular ER. Following Ca²⁺ store depletion, STIMs rapidly cluster and ...