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25 results for "NFkB/IkB Inhibitors" in 产品

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NFkB/IkB Inhibitors

NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.

MG 132

Catalog #: 1748

(5)

Alternate Names:	Z-LLL-al,Z-Leu-Leu-Leu-CHO
Chemical Name:	N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
Purity:	≥95%

Chemical Name:	2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
Purity:	≥97%

Alternate Names:	Bay 11-7083
Chemical Name:	(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
Purity:	≥98%

Alternate Names:	CAPE
Chemical Name:	3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester
Purity:	≥98%

Chemical Name:	(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
Purity:	≥98%

Chemical Name:	2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile
Purity:	≥97%

Chemical Name:	N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride
Purity:	≥98%

Alternate Names:	Zometa
Chemical Name:	[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
Purity:	≥98%

Chemical Name:	(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one
Purity:	≥98%

Chemical Name:	(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Purity:	≥98%

Chemical Name:	N¹-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride
Purity:	≥98%

Chemical Name:	5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid
Purity:	≥97%

Chemical Name:	N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
Purity:	≥98%

Chemical Name:	4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
Purity:	≥98%

Alternate Names:	(-)-Arctigenin
Chemical Name:	(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
Purity:	≥98%

Chemical Name:	N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
Purity:	≥98%

Alternate Names:	3',4',5,7-Tetrahydroxyflavone
Chemical Name:	2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
Purity:	≥98%

Chemical Name:	8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide
Purity:	≥98%

Chemical Name:	2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Purity:	≥98%

Chemical Name:	N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride
Purity:	≥98%

NFkB/IkB Inhibitors

MG 132

TPCA-1

Bay 11-7085

Caffeic acid phenethyl ester

Triptolide

ACHP

IKK 16

Zoledronic Acid

Cardamonin

Celastrol

BMS 345541

Sulfasalazine

SP 100030

FPS ZM1

Arctigenin

IMD 0354

Luteolin

PF 184

Amlexanox

ML 120B dihydrochloride

IP7e

GSK 319347A

C-DIM 12

NIKi

C25-140

Chemical Name:	6-[4-[(2-Methoxyethoxy)methyl]phenyl]-5-methyl-3-phenyl-isoxazolo[4,5-c]pyridin-4(5H)-one
Purity:	≥98%

Chemical Name:	5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile
Purity:	≥98%

Chemical Name:	3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]
Purity:	≥98%

Chemical Name:	4-[3-[2-Amino-5-(2-methoxyethoxy)-4-pyrimidinyl]-1H-indol-5-yl]-2-methyl-3-butyn-2-ol
Purity:	≥98%

Chemical Name:	3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
Purity:	≥98%