Human Active MMP-9 Fluorokine E Kit

R&D Systems | Catalog # F9M00

Contains Mercury, Dispose According to Local, State or Federal Laws. Contains p-Aminophenylmercuric Acetate (APMA), a mercury compound. Review Safety Data Sheet (SDS) before use for safety instructions.
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Key Product Details

Species

Human

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: MMP-9

MMP-9 (Gelatinase B) is a metalloproteinase that degrades multiple extracellular matrix components including Gelatin, Collagens III, IV, V, and XI, Elastin, Nidogen-1, and Vitronectin. It also cleaves a variety of chemokines and growth factors (e.g. IL-1 beta, CXCL8/IL-8, CXCL7, CXCL4, CXCL1, Latent TGF-beta, membrane bound TNF-alpha, VEGF, and FGF basic), Amyloid beta peptide, Substance P, and Myelin Basic Protein. MMP-9 can trigger signaling through various transmembrane proteins or inhibit signaling by inducing their shedding from the cell surface (e.g. CD44, E-Cadherin, Integrins, ICAM-1, and CD25/IL-2 R alpha). The activity of MMP-9 is regulated by its association with the TIMP-1 protease inhibitor. Circulating levels of MMP-9 are elevated in many inflammatory disorders including intraluminal thrombus formation, atherosclerosis, Crohn’s disease, hepatitis C virus infection, colorectal cancer, and Duchenne muscular dystrophy.

Long Name

Matrix Metalloproteinase 9

Alternate Names

CLG4B, Gelatinase B, GELB, MANDP2, MMP9

Entrez Gene IDs

4318 (Human); 17395 (Mouse); 81687 (Rat); 102117693 (Cynomolgus Monkey)

Gene Symbol

MMP9

Additional MMP-9 Products

Product Documents for Human Active MMP-9 Fluorokine E Kit

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Active MMP-9 Fluorokine E Kit

For research use only

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov.

Citations for Human Active MMP-9 Fluorokine E Kit

Customer Reviews for Human Active MMP-9 Fluorokine E Kit (2)

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  • Human Active MMP-9 Fluorokine E Kit
    Name: Anonymous
    Verified Customer | Posted 01/20/2021
    Easy to use and gives reliable results.
  • Human Active MMP-9 Fluorokine E Kit
    Name: Leslie Priddy
    Verified Customer | Posted 04/04/2018

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FAQs for Human Active MMP-9 Fluorokine E Kit

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  • Q: Does the Human Active MMP-9 Fluorokine E Kit detect active or pro-MMP-9?

    A: Without using APMA before substrate addition, the kit measures the levels of endogenous active MMP-9. With using APMA before substrate addition, the kit measures the levels of endogenous active MMP-9 and levels of the MMP-9 that can be activated by APMA, which reflects the sum of active MMP-9 and pro-MMP-9.

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