Human CD4 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CD4

CD4 is an approximately 55 kDa type I membrane glycoprotein that is expressed predominantly on most thymocytes and a subset of mature T lymphocytes. In humans, CD4 is also expressed to a lesser extent on monocytes and macrophage related cells. Human CD4 cDNA encodes a 458 amino acid (aa) residue precursor protein with a 25 aa residue signal peptide, a 371 aa residue extracellular region containing four immunoglobulin homology domains, a 24 aa residue transmembrane domain and a 38 aa residue cytoplasmic domain. CD4 is a coreceptor required for T cell recognition of antigens that are presented by class II major histocompatibility complexes. CD4 has been shown to be a coreceptor of HIV entry and specifically binds gp120, the external envelope glycoprotein of HIV.

Product Datasheets

Related Research Areas

• Conventional/Classical Dendritic Cells
• gamma delta T Cells
• Infectious Diseases
• Leukocyte Receptors/Markers in Allergy and Asthma
• Leukocyte Receptors/Markers in Tfh Cell Differentiation and Function
• LTi Cells
• Lymphoid Lineage Markers
• Natural Killer T (NKT) Cells
• Regulatory T Cells (Tregs)
• Th1 Cells
• Th17 Cells
• Th2 Cells
• Th22 Cells
• Th9 Cells