Reacts specifically with human and non-human cells expressing human CXCR4 (fusin) as detected by flow cytometry. It will also react with cells expressing feline CXCR4 but not rat CXCR4. This antibody does not cross-react with other chemokine receptors.
Monoclonal Mouse IgG2B Clone # 44717
Protein A or G purified from ascites
Mouse 3T3 cells transfected with human CXCR4
Supplied in a saline solution containing BSA and Sodium Azide.
10 µL/106 cells
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of CXCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CXCR4 Biotinylated Monoclonal Antibody (Catalog # FAB173B) followed by Streptavidin-Phycoerythrin (Catalog # F0040) and Mouse Anti-Human CD19 APC‑conjugated Monoclonal Antibody (Catalog # FAB4867A). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
CXCR4 is a G-protein-linked seven transmembrane spanning receptor that
binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor
for T-cell tropic HIV-1 and -2 viral entry into cells.
R&D Systems personnel manually curate a database that contains references using R&D Systems products.
The data collected includes not only links to publications in PubMed,
but also provides information about sample types, species, and experimental conditions.
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