Human GPR107 is an ‘orphan' 7-transmembrane receptor from the G protein-coupled receptor (GPCR) family of proteins.
GPR107 has been proposed to act as a receptor for Neuronostatin, a peptide derived from the somatostatin/SST precursor. Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic alpha -cells.