Human IFITM2/IFITM3 Antibody
Human IFITM2/IFITM3 Antibody Summary
Accession # Q01628
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Human IFITM2/IFITM3/Fragilis by Western Blot. Western blot shows lysates of human brain tissue and human spleen tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human IFITM2/3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4834) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). Specific bands were detected for IFITM2 and IFITM3 at approximately 15 and 17 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
IFITM3 (IFN-inducible tranemembrane protein 3; also IFN-inducible protein 1-8U and fragilis) is a 14.6 kDa (predicted) member of the CD225 family of proteins. It is expressed on primordial germ cells and select tumor types, and appears to regulate cell migration. Human IFITM3 is a 133 amino acid (aa), two-transmembrene protein that contains an N-terminal (aa 1-57) and a C-terminal (aa 108-128) extracellular domain. Over aa 3-57, human IFITM3 is 59% and 56% aa identical to bovine and mouse IFITM3, respectively. Over aa 3-57 human IFITM3 is 88% identical to human IFITM2.
Citations for Human IFITM2/IFITM3 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses
Authors: M Clement, JL Forbester, M Marsden, P Sabberwal, MS Sommervill, D Wellington, S Dimonte, S Clare, K Harcourt, Z Yin, L Nobre, R Antrobus, B Jin, M Chen, S Makvandi-N, JA Lindborg, SM Strittmatt, MP Weekes, RJ Stanton, T Dong, IR Humphreys
Nature Communications, 2022-09-08;13(1):5294.
Sample Types: Whole Cells
?20 IFITM2 differentially restricts X4 and R5 HIV-1
Authors: WL Wu, CR Grotefend, MT Tsai, YL Wang, V Radic, H Eoh, IC Huang
Proc. Natl. Acad. Sci. U.S.A., 2017-06-19;114(27):7112-7117.
Sample Types: Recombinant Protein, Whole Cells
Applications: ICC, Western Blot
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