Human IL-20 Antibody
Human IL-20 Antibody Summary
Accession # AAF36679
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Human Interleukin 20 (IL-20) was identified by searching sequence databases for translated sequences containing a signal sequence and amphipathic helices found in helical cytokines. Human IL-20 is synthesized as a 176 amino acid (aa) precursor with a 24 aa signal sequence and a 152 aa mature segment. There are no N-linked glycosylation sites and it is doubtful that the native molecule is glycosylated. Although IL-20 is a distant member of the IL-10 family, it functions as a monomer. IL‑20 shares less than 40% aa sequence identity with other IL-10 family members. Mouse and human IL‑20 share 77% aa sequence identity in their mature segments. Human IL‑20 is active on mouse cells. IL-20 production has been found in skin and trachea. In particular, activated keratinocytes and, possibly, monocytes are reported to express IL-20. There are two heterodimeric receptor complexes for IL-20. The first is composed of IL-20 R alpha and IL-20 R beta. The second is composed of IL‑22 R and IL-20 R beta. Whereas the IL-22 R/IL-20 R beta complex is shared with IL-24/mda-7, the IL-20 R alpha /IL-20 R beta complex is shared with both IL-19 and IL-24. Little is known about the function of IL-20. It is reported to induce the proliferation of multipotential hematopoietic progenitor cells, direct the differentiation and expansion of keratinocytes, and promote the release of proinflammatory mediators in keratinocytes and other IL-20 receptor expressing cells (1-6).
- Blumberg, H. et al. (2001) Cell 104:9.
- Liu, L. et al. (2003) Blood 102:3206.
- Rich, B.E. and T.S. Kupper (2001) Curr. Biol. 11:R531.
- Pestka, S. et al. (2004) Annu. Rev. Immunol. 22:929.
- Dumoutier, L. (2001) J. Immunol. 167:3545.
- Romer, J. (2003) J. Invest. Dermatol. 121:1306.
Citation for Human IL-20 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis.
Authors: Hsu YH, Li HH, Hsieh MY, Liu MF, Huang KY, Chin LS, Chen PC, Cheng HH, Chang MS
Arthritis Rheum., 2006-09-01;54(9):2722-33.
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-P
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