Human MALT1 Antibody

    
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  • Species Reactivity
    Human
  • Specificity
    Detects human MALT1 in Western blots.
  • Source
    Monoclonal Mouse IgG1 Clone # MALT1-C
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Recombinant human MALT1
    Asp701-Thr808
    Accession # Q9UDY8
  • Formulation
    Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
  • Label
    Unconjugated
Product Datasheets

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Applications
  •  
    Recommended
    Concentration
    Sample
  • Western Blot
    1 µg/mL
    See below
  • Simple Western
    10 µg/mL
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples

Detection of Human MALT1 by Western Blot. Western blot shows lysates of Jurkat human acute T cell leukemia cell line and Daudi human Burkitt's lymphoma cell line. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human MALT1 Monoclonal Antibody (Catalog # MAB4850) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for MALT1 at approximately 100 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.

Detection of Human MALT1 by Simple WesternTM. Simple Western lane view shows lysates of Jurkat human acute T cell leukemia cell line and Daudi human Burkitt's lymphoma cell line, loaded at 0.2 mg/mL. A specific band was detected for MALT1 at approximately 98 kDa (as indicated) using 10 µg/mL of Mouse Anti-Human MALT1 Monoclonal Antibody (Catalog # MAB4850). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Preparation and Storage
  • Reconstitution
    Reconstitute at 0.5 mg/mL in sterile PBS.
    Reconstitution Buffer Available
  • Shipping
    The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
  • Stability & Storage
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is an approximately 91 kDa intracellular adaptor protein that forms a complex with Bcl10 and CARMA-1. The caspase-like domain of MALT1 cleaves Bcl10 and the NF kappa B inhibitor A20. This results in NF kappa B activation following signal transduction from cell surface ITAM-containing receptors including the T cell and B cell antigen receptors. Human MALT1 shares 87% aa sequence identity with mouse and rat MALT1.
  • Long Name:
    Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1
  • Entrez Gene IDs:
    10892 (Human); 240354 (Mouse); 307366 (Rat)
  • Alternate Names:
    caspase-like protein; DKFZp434L132; EC 3.4.22.-; MALT associated translocation; MALT lymphoma-associated translocation; MALT1; MLT1; MLTMALT-lymphoma associated translocation; mucosa associated lymphoid tissue lymphoma translocation gene 1; mucosa-associated lymphoid tissue lymphoma translocation protein 1; Paracaspase
Related Research Areas

FAQs

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Isotype Controls
Description Application Cat# Citations Images  

Mouse IgG1 Isotype Control

Ctrl MAB002 148  
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Mouse IgG1 Isotype Control

Ctrl MAB002R 1
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Reconstitution Buffers
Description Application Cat# Citations Images  

Reconstitution Buffer 1 (PBS)

RB01
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Secondary Antibodies
Description Application Cat# Citations Images  

Mouse IgG HRP-conjugated Antibody

WB HAF007 32  
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Mouse F(ab)2 IgG (H+L) PE-conjugated Antibody

Flow F0102B 12  
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Donkey Anti-Mouse IgG NorthernLights™ NL557-conjugate Antibody

Flow , IHC , ICC NL007 10
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Mouse IgG HRP-conjugated Antibody

WB HAF018 9  
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Donkey Anti-Mouse IgG NorthernLights™ NL637-conjugated Antibody

Flow , IHC , ICC NL008 8
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Mouse F(ab)2 IgG (H+L) APC-conjugated Antibody

Flow F0101B 4  
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Donkey Anti-Mouse IgG Biotinylated Antibody

WB BAF018 1
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Mouse IgG Antibody

WB AF007 4
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Donkey Anti-Mouse IgG NorthernLights™ NL493-conjugated Antibody

Flow , IHC , ICC NL009 5
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Mouse F(ab)2 IgG (H+L) Fluorescein-conjugated Antibody

Flow F0103B 5  
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Goat Anti-Mouse IgG Biotinylated Antibody

WB BAF007 4
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Mouse/Rabbit IgG VisUCyte HRP Polymer Antibody

IHC VC002  
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Mouse IgG VisUCyte HRP Polymer Antibody

IHC VC001  
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Mouse F(ab)2 IgG (H+L) PerCP-conjugated Antibody

Flow F0114  
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