Human MD-2 Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (2)
Supplemental Products
Reviews (1)

Human MD-2 Antibody Summary

Species Reactivity
Detects human MD-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross‑react with recombinant human MD-1.
Monoclonal Mouse IgG1 Clone # 288307
Protein A or G purified from hybridoma culture supernatant
E. coli-derived recombinant human MD-2
Accession # Q9Y6Y9
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
1 µg/mL
Recombinant Human MD‑2 (Catalog # 1787-MD)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: MD2

MD-2, also known as lymphocyte antigen 96 and ESOP-1, is a secreted glycoprotein that associates with the extracellular domain of TLR4. MD-2 is required for LPS binding and subsequent TLR4 signaling.

Long Name
Myeloid Differentiation Protein 2/Lymphocyte Antigen 96
Entrez Gene IDs
23643 (Human); 17087 (Mouse); 102118398 (Cynomolgus Monkey)
Alternate Names
ESOP1; ESOP-1; LY96; ly-96; lymphocyte antigen 96; MD2; MD-2; myeloid differentiation protein-2; Protein MD-2

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Citations for Human MD-2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14(+) Monocytes
    Authors: JM Horvatinov, EW Grogan, M Norris, A Steinkasse, H Lemos, AL Mellor, IY Tcherepano, CA Nicolette, MA DeBenedett
    J. Immunol, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  2. A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression.
    Authors: Macagno A, Molteni M, Rinaldi A
    J. Exp. Med., 2006;203(6):1481-92.
    Species: Human
    Sample Types: Buffer
    Applications: ELISA Development


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Reviews for Human MD-2 Antibody

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Human MD-2 Antibody
By Anonymous on 03/29/2021
Application: ELISA Sample Tested: wheat extracts Species: wheat

we use this antibody to see interactions with TLR4/MD2 complex and MD2 recombinant protein. Works well at a minimum of 1:10 folds in direct ELISA.