Human mGluR4 (NP_000832) VersaClone cDNA

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Key Product Details

Species

Human

Accession Number

NP_000832

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: mGluR4

The Metabotropic Glutamate Receptor mGluR4/GRM4 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group III includes GRM4, GRM6, GRM7, and GRM8 receptors that are linked to the inhibition of the cyclic AMP signaling cascade. Two protein isoforms have been reported in rat (mGluR4a 912 aa; mGluRb 983 aa), which differ at the C-terminus. GRM4 has been reported in various regions of the brain, eye, and spinal cord. ESTs have been isolated from brain, embryo, melanocyte/uterus/fetal heart, nerve, and testis libraries. Caution: GLUR4 refers to Ionotropic Glutamate Receptor 4, not to Metabotropic Glutamate Receptor 4 (mGLUR4).

Long Name

Metabotropic Glutamate Receptor 4

Alternate Names

GPRC1D, GRM4

Entrez Gene IDs

2914 (Human); 268934 (Mouse); 24417 (Rat)

Gene Symbol

GRM4

UniProt

NP_000832

Additional mGluR4 Products

Product Documents for Human mGluR4 (NP_000832) VersaClone cDNA

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Product Specific Notices for Human mGluR4 (NP_000832) VersaClone cDNA

For research use only

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