Human Osteoprotegerin/TNFRSF11B DuoSet ELISA

Catalog # Availability Size / Price Qty
DY805
Ancillary Products Available
Human Osteoprotegerin / TNFRSF11B ELISA Standard Curve
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Product Details
Citations (83)
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Human Osteoprotegerin/TNFRSF11B DuoSet ELISA Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Sample Volume Required
100 µL
Assay Range
62.5 - 4,000 pg/mL
Sufficient Materials
For fifteen 96-well plates*
Specificity
Please see the product datasheet

* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.

This DuoSet ELISA Development kit contains the basic components required for the development of sandwich ELISAs to measure natural and recombinant human Osteoprotegerin / TNFRSF11B. The suggested diluent is suitable for the analysis of most cell culture supernate samples. Diluents for complex matrices, such as serum and plasma, should be evaluated prior to use in this DuoSet ELISA.

Product Features

  • Optimized capture and detection antibody pairings with recommended concentrations save lengthy development time
  • Development protocols are provided to guide further assay optimization
  • Assay can be customized to your specific needs
  • Economical alternative to complete kits

Kit Content

  • Capture Antibody
  • Detection Antibody
  • Recombinant Standard
  • Streptavidin conjugated to horseradish-peroxidase (Streptavidin-HRP)

Other Reagents Required


PBS: (Catalog # DY006), or 137 mM NaCl, 2.7 mM KCl, 8.1 mM Na2HPO4, 1.5 mM KH2PO4, pH 7.2 - 7.4, 0.2 µm filtered

Wash Buffer: (Catalog # WA126), or equivalent

Reagent Diluent*

Blocking Buffer*

Substrate Solution: 1:1 mixture of Color Reagent A (H2O2) and Color Reagent B (Tetramethylbenzidine) (Catalog # DY999)

Stop Solution: 2 N H2SO4 (Catalog # DY994)

Microplates: R&D Systems (Catalog # DY990), or equivalent

Plate Sealers: ELISA Plate Sealers (Catalog # DY992), or equivalent

*For the Reagent Diluent and Blocking Buffer recommended for a specific DuoSet ELISA Development Kit, please see the product .

Scientific Data

Human Osteoprotegerin / TNFRSF11B ELISA Standard Curve

Product Datasheets

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: Osteoprotegerin/TNFRSF11B

Osteoprotegerin (OPG), also known as OCIF and TNFRSF11B, is a secreted TNF superfamily receptor that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts, and endothelial cells. OPG functions as a decoy receptor for TRANCE/RANK L and TRAIL. OPG regulates the cell surface expression of TRANCE and its ability to stimulate osteoclastogenesis. Dysregulation of OPG/TRANCE interactions can lead to juvenile Paget’s disease, osteoporosis, bone loss, and vascular calcification.

Entrez Gene IDs:
4982 (Human); 18383 (Mouse)
Alternate Names:
OCIF; OCIFMGC29565; OPG; OPGtumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; TR1; tumor necrosis factor receptor superfamily, member 11b

Citations for Human Osteoprotegerin/TNFRSF11B DuoSet ELISA

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

83 Citations: Showing 1 - 10
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  1. New Hyaluronic Acid from Plant Origin to Improve Joint Protection-An In Vitro Study
    Authors: R Galla, S Ruga, S Aprile, S Ferrari, A Brovero, G Grosa, C Molinari, F Uberti
    International Journal of Molecular Sciences, 2022;23(15):.
    Species: Human
    Sample Types: Cell Lysates
  2. Plasma osteoprotegerin level is associated with hemorrhagic transformation in stroke patients who underwent endovascular thrombectomy
    Authors: HJ Kim, MS Park, A Joo, S Kang, S Eum, Y Chang, TJ Song
    Clinical neurology and neurosurgery, 2022;219(0):107305.
    Species: Human
    Sample Types: Plasma
  3. Hypoxia Preconditioned Serum (HPS) Promotes Osteoblast Proliferation, Migration and Matrix Deposition
    Authors: J Jiang, L Röper, S Alageel, U Dornseifer, AF Schilling, E Hadjipanay, HG Machens, P Moog
    Oncogene, 2022;10(7):.
    Species: Human
    Sample Types: Cell Culture Supernates
  4. e-Cigarette Vapour Condensate Reduces Viability and Impairs Function of Human Osteoblasts, in Part, via a Nicotine Dependent Mechanism
    Authors: T Nicholson, L Davis, ET Davis, M Newton Ede, A Scott, SW Jones
    Toxics, 2022;10(9):.
    Species: Human
    Sample Types: Cell Culture Supernates
  5. Mineralizing Gelatin Microparticles as Cell Carrier and Drug Delivery System for siRNA for Bone Tissue Engineering
    Authors: S Hinkelmann, AH Springwald, S Schulze, U Hempel, F Mitrach, C Wölk, MC Hacker, M Schulz-Sie
    Pharmaceutics, 2022;14(3):.
    Species: Human
    Sample Types: Cell Culture Supernates
  6. Rank-Rankl-Opg Axis in Multiple Sclerosis: The Contribution of Placenta
    Authors: S Passaponti, L Ermini, G Acconci, FM Severi, R Romagnoli, S Cutrupi, M Clerico, G Guerrera, F Ietta
    Cells, 2022;11(8):.
    Species: Human
    Sample Types: Cell Culture Supernates
  7. The association of plasma osteoprotegerin levels and functional outcomes post endovascular thrombectomy in acute ischemic stroke patients: a retrospective observational study
    Authors: MS Park, JH Park, A Joo, Y Chang, TJ Song
    PeerJ, 2022;10(0):e13327.
    Species: Human
    Sample Types: Plasma
  8. Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM
    Authors: KEC Blokland, H Habibie, T Borghuis, GJ Teitsma, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess
    Cells, 2021;10(7):.
    Species: Human
    Sample Types: Cell Culture Supernates
  9. Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis
    Authors: K Noda, B Dufner, H Ito, K Yoshida, G Balboni, RH Straub
    Scientific Reports, 2021;11(1):18399.
    Species: Human
    Sample Types: Cell Culture Supernates
  10. Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures
    Authors: JW Kennedy, PM Tsimbouri, P Campsie, S Sood, PG Childs, S Reid, PS Young, DRM Meek, CS Goodyear, MJ Dalby
    Scientific Reports, 2021;11(1):22741.
    Species: Human
    Sample Types: Cell Culture Supernates
  11. Plasma osteoprotegerin levels are associated with the presence and burden of cerebral small vessel disease in patients with acute ischemic stroke
    Authors: MS Park, Y Chang, KH Kim, JH Park, TJ Song
    Clinical neurology and neurosurgery, 2021;210(0):107010.
    Species: Human
    Sample Types: Plasma
  12. Osteoprotegerin is a marker of cardiovascular�mortality�in patients with chronic kidney disease stages 3-5
    Authors: GL Marques, S Hayashi, A Bjällmark, M Larsson, M Riella, M Olandoski, B Lindholm, MM Nascimento
    Scientific Reports, 2021;11(1):2473.
    Species: Human
    Sample Types: Serum
  13. Endothelial glycocalyx degradation and disease severity in Plasmodium vivax and Plasmodium knowlesi malaria
    Authors: BE Barber, MJ Grigg, KA Piera, Y Chen, T William, JB Weinberg, TW Yeo, NM Anstey
    Scientific Reports, 2021;11(1):9741.
    Species: Plasma
    Sample Types:
  14. Role of PDT as an adjunct to SRP on whole salivary RANKL and OPG ratio in type-2 diabetic and normoglycemic individuals with chronic periodontitis
    Authors: B Shetty, DD Divakar, AA Al-Kheraif, AO Alharbi, MST Almutairi, MM Alanazi
    Photodiagnosis and photodynamic therapy, 2021;0(0):102220.
    Species: Human
    Sample Types: Saliva
  15. Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients
    Authors: HK Pihlstrøm, T Ueland, AE Michelsen, P Aukrust, F Gatti, C Hammarströ, M Kasprzycka, J Wang, G Haraldsen, G Mjøen, DO Dahle, K Midtvedt, IA Eide, A Hartmann, H Holdaas
    PLoS ONE, 2020;15(12):e0243759.
    Species: Human
    Sample Types: Plasma
  16. Osteoprotegerin is More than a Possible Serum Marker in Liver Fibrosis: A Study into its Function in Human and Murine Liver
    Authors: A Adhyatmika, L Beljaars, KSS Putri, H Habibie, CE Boorsma, C Reker-Smit, T Luangmonko, B Guney, A Haak, KA Mangnus, E Post, K Poelstra, K Ravnskjaer, P Olinga, BN Melgert
    Pharmaceutics, 2020;12(5):.
    Species: Human
    Sample Types: Serum
  17. Sex Differences in Proatherogenic Cytokine Levels
    Authors: S Bernardi, B Toffoli, F Tonon, M Francica, E Campagnolo, T Ferretti, S Comar, F Giudici, E Stenner, B Fabris
    Int J Mol Sci, 2020;21(11):.
    Species: Human
    Sample Types:
  18. Plasma Osteoprotegerin Correlates with Stroke Severity and the Occurrence of Microembolic Signals in Patients with Acute Ischemic Stroke
    Authors: Y Cao, C Cui, H Zhao, X Pan, W Li, K Wang, A Ma
    Dis. Markers, 2019;2019(0):3090364.
    Species: Human
    Sample Types: Plasma
  19. The effect of compressive force combined with mechanical vibration on human alveolar bone osteoblasts
    Authors: C Chatmahamo, A Pravithara, S Suttapreya, C Leethanaku
    J Oral Biol Craniofac Res, 2019;9(1):81-85.
    Species: Human
    Sample Types: Cell Culture Supernates
  20. Inflammatory Bowel Disease Types Differ in Markers of Inflammation, Gut Barrier and in Specific Anti-Bacterial Response
    Authors: S Coufal, N Galanova, L Bajer, Z Gajdarova, D Schierova, Z Jiraskova, K Kostovciko, Z Jackova, Z Stehlikova, P Drastich, H Tlaskalova, M Kverka
    Cells, 2019;8(7):.
    Species: Human
    Sample Types: Serum
  21. Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds
    Authors: X Ren, Q Zhou, D Foulad, AS Tiffany, MJ Dewey, D Bischoff, TA Miller, RR Reid, TC He, DT Yamaguchi, BAC Harley, JC Lee
    Sci Adv, 2019;5(6):eaaw4991.
    Species: Human
    Sample Types: Cell Culture Supernates
  22. A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment
    Authors: J Kang, YJ Choi, BY Seo, U Jo, SI Park, YH Kim, KH Park
    Sci Rep, 2019;9(1):8726.
    Species: Human
    Sample Types: Cell Culture Supernates
  23. Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells
    Authors: AI Segaliny, JL Cheng, HP Farhoodi, M Toledano, CC Yu, B Tierra, L Hildebrand, L Liu, MJ Liao, J Cho, D Liu, L Sun, G Gulsen, MY Su, RL Sah, W Zhao
    EBioMedicine, 2019;45(0):39-57.
    Species: Human
    Sample Types: Cell Culture Supernates
  24. Low magnitude high frequency vibration induces RANKL via cyclooxygenase pathway in human periodontal ligament cells in vitro
    Authors: S Benjakul, C Leethanaku, S Jitpukdeeb
    J Oral Biol Craniofac Res, 2019;9(3):251-255.
    Species: Human
    Sample Types: Cell Culture Supernates
  25. Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells
    Authors: AI Segaliny, JL Cheng, HP Farhoodi, M Toledano, CC Yu, B Tierra, L Hildebrand, L Liu, MJ Liao, J Cho, D Liu, L Sun, G Gulsen, MY Su, RL Sah, W Zhao
    EBioMedicine, 2019;45(0):39-57.
    Species: Human
    Sample Types: Cell Culture Supernates
  26. 6-Shogaol Suppresses 2-Amino-1-Methyl-6-Phenylimidazo [4,5-b] Pyridine (PhIP)-Induced Human 786-O Renal Cell Carcinoma Osteoclastogenic Activity and Metastatic Potential
    Authors: IJ Yeh, SC Chen, MC Yen, YH Wu, CH Hung, PL Kuo
    Nutrients, 2019;11(10):.
    Species: Human
    Sample Types: Cell Culture Supernates
  27. Gender-independent efficacy of mesenchymal stem cell therapy in sex hormone-deficient bone loss via immunosuppression and resident stem cell recovery
    Authors: BD Sui, J Chen, XY Zhang, T He, P Zhao, CX Zheng, M Li, CH Hu, Y Jin
    Exp. Mol. Med., 2018;50(12):166.
    Species: Human
    Sample Types: Serum
  28. Role of Wnt11 during Osteogenic Differentiation of Human Mesenchymal Stem Cells on Microstructured Titanium Surfaces
    Authors: BD Boyan, R Olivares-N, MB Berger, SL Hyzy, Z Schwartz
    Sci Rep, 2018;8(1):8588.
    Species: Human
    Sample Types: Cell Culture Supernates
  29. Osteoprotegerin Is Associated With Major Bleeding But Not With Cardiovascular Outcomes in Patients With Acute Coronary Syndromes: Insights From the PLATO (Platelet Inhibition and Patient Outcomes) Trial
    Authors: T Ueland, A Åkerblom, T Ghukasyan, AE Michelsen, P Aukrust, RC Becker, M Bertilsson, A Himmelmann, SK James, A Siegbahn, RF Storey, F Kontny, L Wallentin,
    J Am Heart Assoc, 2018;7(2):.
    Species: Human
    Sample Types: Plasma
  30. Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of osteoinhibition
    Authors: EP McNeill, RW Reese, A Tondon, BH Clough, S Pan, J Froese, D Palmer, U Krause, DM Loeb, R Kaunas, CA Gregory
    Cell Death Dis, 2018;9(12):1161.
    Species: Human
    Sample Types: Cell Culture Supernates
  31. RANKL Inhibits the Production of Osteoprotegerin from Smooth Muscle Cells under Basal Conditions and following Exposure to Cyclic Strain
    Authors: C Davenport, E Harper, KD Rochfort, H Forde, D Smith, PM Cummins
    J. Vasc. Res., 2018;55(2):111-123.
    Species: Human
    Sample Types: Cell Culture Supernates
  32. Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
    Authors: F Mizoguchi, K Slowikowsk, K Wei, JL Marshall, DA Rao, SK Chang, HN Nguyen, EH Noss, JD Turner, BE Earp, PE Blazar, J Wright, BP Simmons, LT Donlin, GD Kalliolias, SM Goodman, VP Bykerk, LB Ivashkiv, JA Lederer, N Hacohen, PA Nigrovic, A Filer, CD Buckley, S Raychaudhu, MB Brenner
    Nat Commun, 2018;9(1):789.
    Species: Human
    Sample Types: Cell Culture Supernates
  33. Rapid Osteogenic Enhancement of Stem Cells in Human Bone Marrow Using a Glycogen-Synthease-Kinase-3-Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo
    Authors: BH Clough, S Zeitouni, U Krause, CD Chaput, LM Cross, AK Gaharwar, CA Gregory
    Stem Cells Transl Med, 2018;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Capture
  34. Effects of osteoprotegerin/TNFRSF11B in two models of abdominal aortic aneurysms
    Authors: E Vorkapic, A Kunath, D Wågsäter
    Mol Med Rep, 2018;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  35. Type 2 diabetes affects bone cells precursors and bone turnover
    Authors: F Sassi, I Buondonno, C Luppi, E Spertino, E Stratta, M Di Stefano, M Ravazzoli, G Isaia, M Trento, P Passera, M Porta, GC Isaia, P D'Amelio
    BMC Endocr Disord, 2018;18(1):55.
    Species: Human
    Sample Types: Serum
  36. Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress
    Authors: M Rogers, N Maldonado-, JD Hutcheson, C Goettsch, S Goto, I Yamada, T Faits, H Sesaki, M Aikawa, E Aikawa
    Circ. Res., 2017;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  37. Serum Tartrate-resistant Acid Phosphatase-5b Levels are Associated with the Severity and Extent of Coronary Atherosclerosis in Patients with Coronary Artery Disease
    Authors: T Morisawa, A Nakagomi, K Kohashi, Y Kusama, W Shimizu
    J. Atheroscler. Thromb., 2017;0(0):.
    Species: Human
    Sample Types: Plasma
  38. Osteoprotegerin Is a New Regulator of Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy
    Authors: AM Abu El-Asr, S Struyf, G Mohammad, M Gouwy, P Rytinx, MM Siddiquei, C Hernández, K Alam, A Mousa, G De Hertogh, G Opdenakker, R Simó
    Invest. Ophthalmol. Vis. Sci., 2017;58(7):3189-3201.
    Species: Human
    Sample Types: Vitreous Humor
  39. TRAIL attenuates RANKL-mediated osteoblastic signalling in vascular cell mono-culture and co-culture models
    Authors: E Harper, KD Rochfort, H Forde, C Davenport, D Smith, PM Cummins
    PLoS ONE, 2017;12(11):e0188192.
    Species: Human
    Sample Types: Cell Culture Supernates
  40. Association of salivary RANKL and osteoprotegerin levels with periodontal health.
    Authors: A A Ochanji, N K Matu, T K Mulli
    Clinical and Experimental Dental Research, 2017;0(0):2057-4347.
    Species: Human
    Sample Types: Saliva
  41. Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells
    Authors: ST Chung, D Geerts, K Roseman, A Renaud, L Connelly
    Mol. Cancer, 2017;16(1):27.
    Species: Human
    Sample Types: Cell Culture Supernates
  42. Circulating osteoprotegerin is associated with chronic kidney disease in hypertensive patients
    Authors: S Bernardi, B Toffoli, F Bossi, R Candido, E Stenner, R Carretta, F Barbone, B Fabris
    BMC Nephrol, 2017;18(1):219.
    Species: Human
    Sample Types: Serum
  43. Marked elevation in plasma osteoprotegerin constitutes an early and consistent feature of cerebral malaria
    Authors: James S O'Donnell
    Thromb. Haemost., 2016;115(4):773-80.
    Species: Human
    Sample Types: Plasma
  44. Bone remodeling and regulating biomarkers in women at the time of breast cancer diagnosis
    Authors: Song Yao
    Breast Cancer Res. Treat, 2016;0(0):.
    Species: Human
    Sample Types: Serum
  45. Marked elevation in plasma osteoprotegerin constitutes an early and consistent feature of cerebral malaria
    Thromb. Haemost., 2016;115(4):773-80.
    Species: Human
    Sample Types: Plasma
  46. RUNX2 Mutation Impairs 1?,25-Dihydroxyvitamin D3 mediated Osteoclastogenesis in Dental Follicle Cells
    Authors: XZ Wang, XY Sun, CY Zhang, X Yang, WJ Yan, LH Ge, SG Zheng
    Sci Rep, 2016;6(0):24225.
    Species: Human
    Sample Types: Cell Culture Supernates
  47. Effect of low-level laser therapy on bisphosphonate-treated osteoblasts
    Authors: Sang-Hun Shin
    Maxillofac Plast Reconstr Surg, 2016;38(1):48.
    Species: Human
    Sample Types: Cell Culture Supernates
  48. Two Consecutive Days of Crossfit Training Affects Pro and Anti-inflammatory Cytokines and Osteoprotegerin without Impairments in Muscle Power
    Front Physiol, 2016;7(0):260.
    Species: Human
    Sample Types: Serum
  49. Mesenchymal progenitors expressing TRAIL induce apoptosis in sarcomas.
    Authors: Grisendi G, Spano C, D'souza N, Rasini V, Veronesi E, Prapa M, Petrachi T, Piccinno S, Rossignoli F, Burns J, Fiorcari S, Granchi D, Baldini N, Horwitz E, Guarneri V, Conte P, Paolucci P, Dominici M
    Stem Cells, 2015;33(3):859-69.
    Species: Human
    Sample Types: Cell Culture Supernates
  50. Association of TRAIL and Its Receptors with Large-Artery Atherosclerotic Stroke.
    Authors: Pan X, Pang M, Ma A, Wang K, Zhang Z, Zhong Q, Yang S
    PLoS ONE, 2015;10(9):e0136414.
    Species: Human
    Sample Types: Plasma
  51. Elevated Circulating Osteoprotegerin and Renal Dysfunction Predict 15-Year Cardiovascular and All-Cause Mortality: A Prospective Study of Elderly Women.
    Authors: Lewis J, Lim W, Ueland T, Wong G, Zhu K, Lim E, Bollerslev J, Prince R
    PLoS ONE, 2015;10(7):e0134266.
    Species: Human
    Sample Types: Serum
  52. Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection.
    Authors: Chen W, Foo S, Taylor A, Lulla A, Merits A, Hueston L, Forwood M, Walsh N, Sims N, Herrero L, Mahalingam S
    J Virol, 2015;89(1):581-93.
    Species: Human
    Sample Types: Serum
  53. Osteoprotegerin, pericytes and bone-like vascular calcification are associated with carotid plaque stability.
    Authors: Davaine J, Quillard T, Brion R, Laperine O, Guyomarch B, Merlini T, Chatelais M, Guilbaud F, Brennan M, Charrier C, Heymann D, Goueffic Y, Heymann M
    PLoS ONE, 2014;9(9):e107642.
    Species: Human
    Sample Types: Plasma
  54. The effect of rosuvastatin on inflammation, matrix turnover and left ventricular remodeling in dilated cardiomyopathy: a randomized, controlled trial.
    Authors: Broch K, Askevold E, Gjertsen E, Ueland T, Yndestad A, Godang K, Stueflotten W, Andreassen J, Svendsmark R, Smith H, Aakhus S, Aukrust P, Gullestad L
    PLoS ONE, 2014;9(2):e89732.
    Species: Human
    Sample Types: Whole Blood
  55. Localization of microfibrillar-associated protein 4 (MFAP4) in human tissues: clinical evaluation of serum MFAP4 and its association with various cardiovascular conditions.
    Authors: Wulf-Johansson H, Lock Johansson S, Schlosser A, Trommelholt Holm A, Rasmussen L, Mickley H, Diederichsen A, Munkholm H, Poulsen T, Tornoe I, Nielsen V, Marcussen N, Vestbo J, Saekmose S, Holmskov U, Sorensen G
    PLoS ONE, 2013;8(12):e82243.
    Species: Human
    Sample Types: Serum
  56. Relationship between bone mineral density and serum osteoprotegerin in patients with chronic heart failure.
    Authors: Chen Y, Wu Y, Yang W, Wang S, Lee C, Chou N, Hsu R, Lin Y, Lin M, Ho Y, Chen M
    PLoS ONE, 2012;7(8):e44242.
    Species: Human
    Sample Types: Serum
  57. CCR2+CCR5+ T Cells Produce Matrix Metalloproteinase-9 and Osteopontin in the Pathogenesis of Multiple Sclerosis.
    Authors: Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T
    J Immunol, 2012;189(10):5057-65.
    Species: Human
    Sample Types: Cell Culture Supernates
  58. Osteoprotegerin levels are increased in patients with venous thromboembolic disease.
    Authors: Rattazzi M, Faggin E, Galliazzo S
    J. Thromb. Haemost., 2012;10(6):1183-5.
    Species: Human
    Sample Types: Serum
  59. Plasma osteoprotegerin is related to carotid and peripheral arterial disease, but not to myocardial ischemia in type 2 diabetes mellitus.
    Authors: Poulsen MK, Nybo M, Dahl J, Hosbond S, Poulsen TS, Johansen A, Hoilund-Carlsen PF, Beck-Nielsen H, Rasmussen LM, Henriksen JE
    Cardiovasc Diabetol, 2011;10(0):76.
    Species: Human
    Sample Types: Plasma
  60. Serum osteoprotegerin is a predictor for incident cardiovascular disease and mortality in a general population: the Tromso Study.
    Authors: Vik A, Mathiesen EB, Brox J, Wilsgaard T, Njolstad I, Jorgensen L, Hansen JB
    J. Thromb. Haemost., 2011;9(4):638-44.
    Species: Human
    Sample Types: Serum
  61. The roles of Wnt signaling modulators Dickkopf-1 (Dkk1) and Dickkopf-2 (Dkk2) and cell maturation state in osteogenesis on microstructured titanium surfaces.
    Authors: Olivares-Navarrete R, Hyzy S, Wieland M, Boyan BD, Schwartz Z
    Biomaterials, 2010;31(8):2015-24.
    Species: Human
    Sample Types: Cell Lysates
  62. Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study.
    Authors: Eagan TM, Ueland T, Wagner PD, Hardie JA, Mollnes TE, Damas JK, Aukrust P, Bakke PS
    Eur. Respir. J., 2010;35(3):540-8.
    Species: Human
    Sample Types: Plasma
  63. Conjunctival sac fluid contains elevated levels of soluble TRAIL: implications for the anti-tumoral surveillance of the anterior surface of the eye.
    Authors: Secchiero P, Lamberti G, Corallini F, Melloni E, Guarnotta C, Sebastiani A, Zauli G
    J. Cell. Physiol., 2009;218(1):199-204.
    Species: Human
    Sample Types: Conjunctival Fluid
  64. The liberation of fractalkine in the dorsal horn requires microglial cathepsin S.
    Authors: Clark AK, Yip PK, Malcangio M
    J. Neurosci., 2009;29(21):6945-54.
    Species: Human
    Sample Types: Serum
  65. A single-nucleotide polymorphism in the gene encoding osteoprotegerin is associated with diastolic blood pressure in older men.
    Authors: Golledge J, Biros E, Clancy P, Cooper M, Palmer LJ, Norman PE
    Am. J. Hypertens., 2009;22(11):1167-70.
    Species: Human
    Sample Types: Plasma
  66. Paracrine inhibition of osteoblast differentiation induced by neuroblastoma cells.
    Authors: Granchi D, Baglio SR, Amato I, Giunti A, Baldini N
    Int. J. Cancer, 2008;123(7):1526-35.
    Species: Human
    Sample Types: Cell Culture Supernates
  67. Plasma osteoprotegerin levels predict cardiovascular and all-cause mortality and deterioration of kidney function in type 1 diabetic patients with nephropathy.
    Authors: Jorsal A, Tarnow L, Flyvbjerg A, Parving HH, Rossing P, Rasmussen LM
    Diabetologia, 2008;51(11):2100-7.
    Species: Human
    Sample Types: Plasma
  68. Osteoprotegerin released from the vascular wall by heparin mainly derives from vascular smooth muscle cells.
    Authors: Nybo M, Rasmussen LM
    Atherosclerosis, 2008;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  69. Lack of observed association between high plasma osteoprotegerin concentrations and ischemic stroke risk in a healthy population.
    Authors: Nybo M, Johnsen SP, Dethlefsen C, Overvad K, Tjonneland A, Jorgensen JO, Rasmussen LM
    Clin. Chem., 2008;54(12):1969-74.
    Species: Human
    Sample Types: Plasma
  70. Clinical, radiographic, and biochemical characterization of multiple myeloma patients with osteonecrosis of the jaw.
    Authors: Raje N, Woo SB, Hande K, Yap JT, Richardson PG, Vallet S, Treister N, Hideshima T, Sheehy N, Chhetri S, Connell B, Xie W, Tai YT, Szot-Barnes A, Tian M, Schlossman RL, Weller E, Munshi NC, Van Den Abbeele AD, Anderson KC
    Clin. Cancer Res., 2008;14(8):2387-95.
    Species: Human
    Sample Types: Serum
  71. Differential gene expression in cultured osteoblasts and bone marrow stromal cells from patients with Paget's disease of bone.
    Authors: Naot D, Bava U, Matthews B, Callon KE, Gamble GD, Black M, Song S, Pitto RP, Cundy T, Cornish J, Reid IR
    J. Bone Miner. Res., 2007;22(2):298-309.
    Species: Human
    Sample Types: Serum
  72. Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis.
    Authors: Locklin RM, Federici E, Espina B, Hulley PA, Russell RG, Edwards CM
    Mol. Cancer Ther., 2007;6(12):3219-28.
    Species: Human
    Sample Types: Cell Culture Supernates
  73. Heparin induces mobilization of osteoprotegerin into the circulation.
    Authors: Vik A, Brodin E, Sveinbjornsson B, Hansen JB
    Thromb. Haemost., 2007;98(1):148-54.
    Species: Human
    Sample Types: Plasma
  74. Cardiovascular effects of intravenous ghrelin infusion in healthy young men.
    Authors: Vestergaard ET, Andersen NH, Hansen TK, Rasmussen LM, Moller N, Sorensen KE, Sloth E, Jorgensen JO
    Am. J. Physiol. Heart Circ. Physiol., 2007;293(5):H3020-6.
    Species: Human
    Sample Types: Serum
  75. Therapeutic relevance of osteoprotegerin gene therapy in osteosarcoma: blockade of the vicious cycle between tumor cell proliferation and bone resorption.
    Authors: Lamoureux F, Richard P, Wittrant Y, Battaglia S, Pilet P, Trichet V, Blanchard F, Gouin F, Pitard B, Heymann D, Redini F
    Cancer Res., 2007;67(15):7308-18.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  76. Soluble receptor activator of nuclear factor-kappa B ligand and risk for cardiovascular disease.
    Authors: Kiechl S, Schett G, Schwaiger J, Seppi K, Eder P, Egger G, Santer P, Mayr A, Xu Q, Willeit J
    Circulation, 2007;116(4):385-91.
    Species: Human
    Sample Types: Serum
  77. B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease.
    Authors: Kawai T, Matsuyama T, Hosokawa Y, Makihira S, Seki M, Karimbux NY, Goncalves RB, Valverde P, Dibart S, Li YP, Miranda LA, Ernst CW, Izumi Y, Taubman MA
    Am. J. Pathol., 2006;169(3):987-98.
    Species: Human
    Sample Types: Tissue Homogenates
  78. Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts.
    Authors: de Vries TJ, Schoenmaker T, Wattanaroonwong N, van den Hoonaard M, Nieuwenhuijse A, Beertsen W, Everts V
    J. Cell. Biochem., 2006;98(2):370-82.
    Species: Human
    Sample Types: Cell Culture Supernates
  79. PAPP-A and osteoprotegerin, together with interleukin-8 and RANTES, are elevated in the peritoneal fluid of women with endometriosis.
    Authors: Bersinger NA, von Roten S, Wunder DM, Raio L, Dreher E, Mueller MD
    Am. J. Obstet. Gynecol., 2006;195(1):103-8.
    Species: Human
    Sample Types: Peritoneal Fluid
  80. Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis.
    Authors: Mogi M, Otogoto J, Ota N, Togari A
    J. Dent. Res., 2004;83(2):166-9.
    Species: Human
    Sample Types: Gingival Crevicular Fluid (GCF)
  81. Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis.
    Authors: Grimaud E, Soubigou L, Couillaud S, Coipeau P, Moreau A, Passuti N, Gouin F, Redini F, Heymann D
    Am. J. Pathol., 2003;163(5):2021-31.
    Species: Human
    Sample Types: Serum
  82. A variant in the osteoprotegerin gene is associated with coronary atherosclerosis in patients with rheumatoid arthritis: results from a candidate gene study.
    Authors: Chung C, Solus J, Oeser A, Li C, Raggi P, Smith J, Stein C
    Int J Mol Sci, 0;16(2):3885-94.
    Species: Human
    Sample Types: Serum
  83. The influence of vitamin D analogs on calcification modulators, N-terminal pro-B-type natriuretic peptide and inflammatory markers in hemodialysis patients: a randomized crossover study.
    Authors: Hansen D, Rasmussen K, Rasmussen L, Bruunsgaard H, Brandi L
    BMC Nephrol, 0;15(0):130.
    Species: Human
    Sample Types: Plasma

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