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OR
  • Assay Type
    Solid Phase Sandwich ELISA
  • Format
    96-well strip plate
  • Assay Length
    4.5 hours
  • Sensitivity
    9 pg/mL
  • Assay Range
    15.60 - 1,000 pg/mL (Cell Culture Supernates,)
  • Specificity
    Natural and recombinant human VEGF
  • Cross-reactivity
    < 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity observed with 1 or more species tested.
  • Interference
    Interference observed with 1 or more available related molecules.
Product Summary
The Quantikine Human VEGF Immunoassay is a 4.5 hour solid phase ELISA designed to measure VEGF165 levels in cell culture supernates, serum, and plasma. It contains Sf 21-expressed recombinant human VEGF165 and antibodies raised against the recombinant protein. Results obtained for naturally occurring human VEGF and recombinant human VEGF121 showed linear curves that were parallel to the standard curves obtained using the Quantikine Human VEGF Immunoassay standards. These results indicate that this kit can be used to determine relative mass values for natural human VEGF.

Precision
Intra-Assay Precision (Precision within an assay) Three samples of a known concentration were tested in twenty separate assays to assess inter-assay precision. Assays were performed by at least three technicians using two lots of kit components.
Inter-Assay Precision (Precision between assays Three samples of known concentration were tested on one plate to assess intra-assay precision.
Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020404040
Mean53.723591064.52501003
Standard Deviation3.610.646.25.717.461.7
CV%6.74.55.18.876.2

Cell Culture Supernates
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020404040
Mean29.112353132.8128495
Standard Deviation1.9518.42.86.433
CV%6.54.13.58.556.7

Recovery

The recovery of human VEGF spiked to levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=5) 102 95-111
Citrate Plasma (n=5) 100 88-113
EDTA Plasma (n=5) 97 82-113
Heparin Plasma (n=5) 93 82-102
Serum (n=5) 102 92-115
Linearity
To assess the linearity of the assay, samples spiked with high concentrations of VEGF were serially diluted with the appropriate Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Human VEGF Quantikine ELISA Kit
Background: VEGF

Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) or vasculotropin, is a homodimeric 34 - 42 kDa, heparin-binding glycoprotein with potent angiogenic, mitogenic and vascular permeability-enhancing activities specific for endothelial cells. The amino acid sequence of VEGF exhibits primary structural, as well as limited amino acid sequence, homology with that of the A and B chains of PDGF. All eight cysteine residues involved in intra- and inter-chain disulfide bonds are conserved among these growth factors. A cDNA encoding a protein having a 53% amino acid sequence homology in the PDGF-like region of VEGF has been isolated from a human placental cDNA library. This protein, named placenta growth factor (PlGF), is now recognized to be a member of the VEGF family of growth factors. Based on its homology with VEGF, PlGF was also proposed to be an angiogenic factor. Two receptor tyrosine kinases have been described as putative VEGF receptors. Flt-1 (fms-like tyrosine kinase), and KDR (kinase-insert-domain-containing receptor) proteins have been shown to bind VEGF with high affinity.

In vitro, VEGF is a potent endothelial cell mitogen. In cultured endothelial cells, VEGF can activate phospholipase C and induce rapid increases of free cytosolic Ca2+. VEGF has been shown to stimulate von Willebrand factor release from endothelial cells and induce expression of tissue factor activity in endothelial cells as well as in monocytes. VEGF has also been shown to be chemotactic for monocytes and osteoblasts. In vivo, VEGF can induce angiogenesis as well as increase microvascular permeability. As a vascular permeability factor, VEGF acts directly on the endothelium and does not degranulate mast cells. It promotes extravasation of plasma fibrinogen, leading to fibrin deposition which alters the tumor extracellular matrix. The modified extracellular matrix subsequently promotes the migration of macrophages, fibroblasts and endothelial cells. Based on its in vitro and in vivo properties, VEGF is expected to play important roles in inflammation and during normal and pathological angiogenesis, a process that is associated with wound healing, embryonic development, and growth and metastasis of solid tumors. Elevated levels of VEGF have been reported in synovial fluids of rheumatoid arthritis patients and in sera from cancer patients.

    • Long Name
      Vascular Endothelial Growth Factor
    • Entrez Gene IDs
      7422 (Human); 22339 (Mouse); 83785 (Rat); 281572 (Bovine); 403802 (Canine); 493845 (Feline); 30682 (Zebrafish);
    • Alternate Names
      VAS; Vasculotropin; VEGFA; VPF; MVCD1; vascular endothelial growth factor A; Vascular permeability factor; VEGF-A; VEGFMGC70609; VPFvascular endothelial growth factor;
    Related Research Areas
    Assay Procedure
    Refer to the product for complete assay procedure.

    Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
    1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
    2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

    3. Add Assay Diluent
    4.   For Serum & Plasma Samples: Add 100 µL of Assay Diluent to each well.
      For Cell Culture Supernate Samples: Add 50 µL Assay Diluent to each well.

    5. Add Standard, Control, or Sample
    6.   For Serum & Plasma Samples: Add 100 µL of Standard, control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
      For Cell Culture Supernate Samples: Add 200 µL of Standard, control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
    7.   Aspirate each well and wash, repeating the process twice for a total of 3 washes.

    8. 200 µL Conjugate
    9.   Add 200 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
    10.   Aspirate and wash 3 times.

    11. 200 µL Substrate Solution
    12.   Add 200 µL Substrate Solution to each well.
    13.   For Serum & Plasma Samples: Incubate at room temperature for 25 minutes. PROTECT FROM LIGHT.
      For Cell Culture Supernate Samples: Incubate at room temperature for 20 minutes. PROTECT FROM LIGHT.

    14. 50 µL Stop Solution
    15. Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.
    Citations:

    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    Showing Results 1 - 10 of 244
    Filter your results:

    Species
    Sample Type
    1. Osteosarcoma cells promote the production of pro-tumor cytokines in mesenchymal stem cells by inhibiting their osteogenic differentiation through the TGF-beta/Smad2/3 pathway.
      Authors: Tu B, Peng Z, Fan Q, DU L, Yan W, Tang T
      Exp Cell Res, 2014;320(1):164-73.
      Species: Human
      Sample Type: cell culture supernate
    2. Gene electro transfer of plasmid encoding vascular endothelial growth factor for enhanced expression and perfusion in the ischemic swine heart.
      Authors: Hargrave, Barbara, Strange, Robert J, Navare, Sagar, Stratton, Michael, Burcus, Nina, Murray, Len, Lundberg, Cathryn, Bulysheva, Anna, Li, Fanying, Heller, Richard
      PLoS ONE, 2014;9(12):e115235.
      Species: Human
      Sample Type: Tissue Homogenates
    3. Analysis of plasma cytokines and angiogenic factors in patients with pretreated urothelial cancer receiving Pazopanib: the role of circulating interleukin-8 to enhance the prognostic accuracy.
      Authors: Necchi A, Pennati M, Zaffaroni N, Landoni E, Giannatempo P, Raggi D, Schwartz L, Morosi C, Crippa F, Fare E, Nicolai N, Lanocita R, Sava T, Sacco C, Messina C, Ortega C, De Braud F, Salvioni R, Daidone M, Gianni A, Mariani L
      Br J Cancer, 2014;110(1):26-33.
      Species: Human
      Sample Type: Plasma
    4. DeltaNp63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis.
      Authors: Bid, Hemant K, Roberts, Ryan D, Cam, Maren, Cam M, Audino A, Audino, Anthony, Kurmasheva, Raushan, Lin, Jiayuh, Houghton, Peter J, Cam, Hakan, Cam H
      Cancer Res, 2014;74(1):320-9.
    5. Clinical outcome, proteome kinetics and angiogenic factors in serum after thermoablation of colorectal liver metastases.
      Authors: Wertenbroek, Marieke, Schepers, Marianne, Kamminga-Rasker, Hannetta, Bottema, Jan T, Muller Kobold, Anneke C, Roelofsen, Han, de Jong, Koert P
      BMC Cancer, 2013;13(1):266.
      Species: Human
      Sample Type: Serum
    6. A phase I trial and pharmacokinetic study of sorafenib in children with refractory solid tumors or leukemias: a Children's Oncology Group Phase I Consortium report.
      Authors: Widemann B, Kim A, Fox E, Baruchel S, Adamson P, Ingle A, Glade Bender J, Burke M, Weigel B, Stempak D, Balis F, Blaney S
      Clin Cancer Res, 2012;18(21):6011-22.
      Species: Human
      Sample Type: Plasma
    7. Comparison of the levels of the growth factors in umbilical cord serum and human milk and its clinical significance.
      Authors: Patki S, Patki U, Patil R, Indumathi S, Kaingade P, Bulbule A, Nikam A, Pishte A
      Cytokine, 2012;59(2):305-8.
    8. Phase I trial of combretastatin A4 phosphate (CA4P) in combination with bevacizumab in patients with advanced cancer.
      Clin. Cancer Res., 2012;18(12):3428-39.
      Species: Human
      Sample Type: Plasma
    9. XELIRI-bevacizumab versus FOLFIRI-bevacizumab as first-line treatment in patients with metastatic colorectal cancer: a Hellenic Cooperative Oncology Group phase III trial with collateral biomarker analysis.
      BMC Cancer, 2012;12(0):271.
      Species: Human
      Sample Type: Plasma
    10. Biomarkers for antitumor activity of bevacizumab in gastric cancer models.
      Authors: Yamashita-Kashima Y, Fujimoto-Ouchi K, Yorozu K, Kurasawa M, Yanagisawa M, Yasuno H, Mori K
      BMC Cancer, 2012;12(0):37.
      Species: Human
      Sample Type: Tissue Homogenates
    11. Stromal interaction essential for vascular endothelial growth factor A-induced tumour growth via transforming growth factor-beta signalling.
      Authors: Weidenaar AC, Ter Elst A, Kampen KR, Meeuwsen-de Boer TG, de Jonge HJ, Scherpen FJ, den Dunnen WF, Kamps WA, de Bont ES
      Br. J. Cancer, 2011;105(12):1856-63.
      Species: Human
      Sample Type: Cell Culture Supernates
    12. In vitro vascular tube formation testing as a tool for treatment individualisation in patients with cervical cancer.
      Authors: Landt S, Heidecke H, Korlach S, Reuter C, Schwidde I, Barinoff J, Thill M, Sehouli J, Kummel S
      Anticancer Res., 2011;31(8):2609-15.
      Species: Human
      Sample Type: Serum
    13. Prognostic significance of angiogenic factors in uterine cervical cancer.
      Authors: Landt S, Wehling M, Heidecke H, Jeschke S, Korlach S, Stoblen F, Schmid P, Blohmer JU, Lichtenegger W, Sehouli J, Kummel S
      Anticancer Res., 2011;31(8):2589-95.
      Species: Human
      Sample Type: Serum
    14. Mechanism-related circulating proteins as biomarkers for clinical outcome in patients with unresectable hepatocellular carcinoma receiving sunitinib.
      Authors: Harmon CS, DePrimo SE, Raymond E, Cheng AL, Boucher E, Douillard JY, Lim HY, Kim JS, Lechuga MJ, Lanzalone S, Lin X, Faivre S
      J Transl Med, 2011;9(0):120.
      Species: Human
      Sample Type: Plasma
    15. Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a children's oncology group study.
      Authors: Dubois SG, Shusterman S, Ingle AM, Ahern CH, Reid JM, Wu B, Baruchel S, Glade-Bender J, Ivy P, Grier HE, Adamson PC, Blaney SM
      Clin. Cancer Res., 2011;17(15):5113-22.
      Species: Human
      Sample Type: Plasma
    16. Synergistic effects of imatinib and carboplatin on VEGF, PDGF and PDGF-Ralpha/beta expression in squamous cell carcinoma of the head and neck in vitro.
      Authors: Schultz JD, Rotunno S, Riedel F, Anders C, Erben P, Hofheinz RD, Faber A, Thorn C, Sommer JU, Hormann K, Sauter A
      Int. J. Oncol., 2011;38(4):1001-12.
      Species: Human
      Sample Type: Cell Lysates
    17. Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I.
      Authors: Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM
      Cancer Res., 1998;58(17):4008-14.
    18. CD34+ progenitor cells likely are involved in the good functional recovery after intracerebral hemorrhage in humans.
      Authors: Sobrino T, Arias S, Perez-Mato M, Agulla J, Brea D, Rodriguez-Yanez M, Castillo J
      J. Neurosci. Res., 2011;89(7):979-85.
      Species: Human
      Sample Type: Serum
    19. Sensitive plasma protein analysis by microparticle-based proximity ligation assays.
      Authors: Darmanis S, Nong RY, Hammond M, Gu J, Alderborn A, Vanelid J, Siegbahn A, Gustafsdottir S, Ericsson O, Landegren U, Kamali-Moghaddam M
      Mol. Cell Proteomics, 2010;9(2):327-35.
      Species: Human
      Sample Type: Plasma
    20. Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer.
      Authors: Loupakis F, Cremolini C, Fioravanti A
      Br. J. Cancer, 2011;104(8):1262-9.
      Species: Human
      Sample Type: Plasma
    21. Levels of circulating CD45(dim)CD34(+)VEGFR2(+) progenitor cells correlate with outcome in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors.
      Authors: Farace F, Gross-Goupil M, Tournay E, Taylor M, Vimond N, Jacques N, Billiot F, Mauguen A, Hill C, Escudier B
      Br. J. Cancer, 2011;104(7):1144-50.
      Species: Human
      Sample Type: Plasma
    22. The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo.
      Authors: Merdzhanova G, Gout S, Keramidas M, Edmond V, Coll JL, Brambilla C, Brambilla E, Gazzeri S, Eymin B
      Oncogene, 2010;29(39):5392-403.
    23. Plasma haemoxygenase-1 in coronary artery disease. A comparison with angiogenin, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and vascular endothelial growth factor.
      Authors: Idriss NK, Lip GY, Balakrishnan B
      Thromb. Haemost., 2010;104(5):1029-37.
      Species: Human
      Sample Type: Plasma
    24. Myeloid Biomarkers Associated with Glioblastoma Response to Anti-VEGF Therapy with Aflibercept.
      Authors: de Groot JF, Piao Y, Tran H, Gilbert M, Wu HK, Liu J, Bekele BN, Cloughesy T, Mehta M, Robins HI, Lassman A, Deangelis L, Camphausen K, Chen A, Yung W, Prados M, Wen PY, Heymach JV
      Clin. Cancer Res., 2011;17(14):4872-4881.
    25. Differential effect of ischaemic preconditioning on mobilisation and recruitment of haematopoietic and mesenchymal stem cells in porcine myocardial ischaemia-reperfusion.
      Authors: Gyongyosi M, Posa A, Pavo N, Hemetsberger R, Kvakan H, Steiner-Boker S, Petrasi Z, Manczur F, Pavo IJ, Edes IF, Wojta J, Glogar D, Huber K
      Thromb. Haemost., 2010;104(2):376-84.
      Species: Human
      Sample Type: Plasma
    26. Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites.
      Authors: Serra-Perez A, Planas AM, Núñez-O'Mara A, Berra E, Garcia-Villoria J, Ribes A, Santalucia T
      J. Biol. Chem., 2010;285(24):18217-24.
      Species: Human
      Sample Type: Cell Culture Supernates
    27. Defective angiogenesis in hypoplastic human fetal lungs correlates with nitric oxide synthase deficiency that occurs despite enhanced angiopoietin-2 and VEGF.
      Authors: Boucherat O, Franco-Montoya ML, Delacourt C, Martinovic J, Masse V, Elie C, Thebaud B, Benachi A, Bourbon JR
      Am. J. Physiol. Lung Cell Mol. Physiol., 2010;298(6):L849-56.
      Species: Human
      Sample Type: Tissue Homogenates
    28. Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis.
      Authors: Hellerud BC, Nielsen EW, Thorgersen EB, Lindstad JK, Pharo A, Tonnessen TI, Castellheim A, Mollnes TE, Brandtzaeg P
      Crit. Care Med., 2010;38(6):1467-74.
      Species: Porcine
      Sample Type: Plasma
    29. Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis.
      Authors: Bourlev V, Iljasova N, Adamyan L, Larsson A, Olovsson M
      Fertil. Steril., 2010;94(1):52-7.
    30. Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner.
      Authors: Liu ZB, Hou YF, Zhu J
      Oncogene, 2010;29(20):2996-3009.
    31. Inhibition of vascular endothelial growth factor reduces scar formation after glaucoma filtration surgery.
      Authors: Li Z, Van Bergen T, Van de Veire S, Van de Vel I, Moreau H, Dewerchin M, Maudgal PC, Zeyen T, Spileers W, Moons L, Stalmans I
      Invest. Ophthalmol. Vis. Sci., 2009;50(11):5217-25.
      Species: Human
      Sample Type: Aqueous humor
    32. Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth.
      Authors: Ebos JM, Lee CR, Bogdanovic E, Alami J, Van Slyke P, Francia G, Xu P, Mutsaers AJ, Dumont DJ, Kerbel RS
      Cancer Res., 2008;68(2):521-9.
      Species: Human
      Sample Type: Cell Culture Supernates
    33. Effects of the menstrual cycle on lung function variables in women with asthma.
      Authors: Farha S, Asosingh K, Laskowski D, Hammel J, Dweik RA, Wiedemann HP, Erzurum SC
      Am. J. Respir. Crit. Care Med., 2009;180(4):304-10.
      Species: Human
      Sample Type: Serum
    34. Changes in vascular endothelial growth factor, angiopoietins, and Tie-2 levels with G-CSF stimulation in healthy donors.
      Authors: Serefhanoglu S, Goker H, Buyukasik Y, Turgut M, Sayinalp N, Haznedaroglu IC, Aksu S, Akman U, Ozcebe OI
      Ann. Hematol., 2009;88(7):667-71.
      Species: Human
      Sample Type: Plasma
    35. Endocrine gland-derived vascular endothelial growth factor concentrations in follicular fluid and serum may predict ovarian hyperstimulation syndrome in women undergoing controlled ovarian hyperstimulation.
      Authors: Gao MZ, Zhao XM, Sun ZG
      Fertil. Steril., 2011;95(2):673-8.
    36. Are plasma VEGF and its soluble receptor sFlt-1 atherogenic risk factors? Cross-sectional data from the SAPHIR study.
      Authors: Sandhofer A, Tatarczyk T, Kirchmair R, Iglseder B, Paulweber B, Patsch JR, Schratzberger P
      Atherosclerosis, 2009;206(1):265-9.
      Species: Human
      Sample Type: Plasma
    37. Neural stem/progenitor cells promote endothelial cell morphogenesis and protect endothelial cells against ischemia via HIF-1alpha-regulated VEGF signaling.
      Authors: Roitbak T, Li L, Cunningham LA
      J. Cereb. Blood Flow Metab., 2008;28(9):1530-42.
      Species: Human
      Sample Type: Cell Culture Supernates
    38. Phase 1/2 study of preoperative docetaxel and mitoxantrone for high-risk prostate cancer.
      Authors: Garzotto M, Higano CS, O'Brien C, Rademacher BL, Janeba N, Fazli L, Lange PH, Lieberman S, Beer TM
      Cancer, 2010;116(7):1699-708.
      Species: Human
      Sample Type: Plasma
    39. Differential regulation of VEGF after final oocyte maturation with GnRH agonist versus hCG: a rationale for OHSS reduction.
      Authors: Cerrillo M, Rodriguez S, Mayoral M, Pacheco A, Martinez-Salazar J, Garcia-Velasco JA
      Fertil. Steril., 2009;91(4):1526-8.
    40. Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors.
      Authors: Kulke MH, Bergsland EK, Ryan DP, Enzinger PC, Lynch TJ, Zhu AX, Meyerhardt JA, Heymach JV, Fogler WE, Sidor C, Michelini A, Kinsella K, Venook AP, Fuchs CS
      J. Clin. Oncol., 2006;24(22):3555-61.
      Species: Human
      Sample Type: Urine
    41. Colorectal resection is associated with persistent proangiogenic plasma protein changes: postoperative plasma stimulates in vitro endothelial cell growth, migration, and invasion.
      Authors: Shantha Kumara HM, Feingold D, Kalady M, Dujovny N, Senagore A, Hyman N, Cekic V, Whelan RL
      Ann. Surg., 2009;249(6):973-7.
      Species: Human
      Sample Type: Plasma
    42. Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes.
      Authors: Rodriguez PC, Ernstoff MS, Hernandez C, Atkins M, Zabaleta J, Sierra R, Ochoa AC
      Cancer Res., 2009;69(4):1553-60.
      Species: Human
      Sample Type: Plasma
    43. Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma.
      Authors: Rini BI, Michaelson MD, Rosenberg JE, Bukowski RM, Sosman JA, Stadler WM, Hutson TE, Margolin K, Harmon CS, DePrimo SE, Kim ST, Chen I, George DJ
      J. Clin. Oncol., 2008;26(22):3743-8.
      Species: Human
      Sample Type: Plasma
    44. VEGF-mediated angiogenesis stimulates neural stem cell proliferation and differentiation in the premature brain.
      Authors: Sun J, Sha B, Zhou W, Yang Y
      Biochem. Biophys. Res. Commun., 2010;394(1):146-52.
      Species: Human
      Sample Type: Cell Culture Supernates
    45. Regulation of vascular endothelial growth factor-A and its soluble receptor sFlt-1 by luteinizing hormone in vivo: implication for ovarian follicle angiogenesis.
      Authors: Gutman G, Barak V, Maslovitz S, Amit A, Lessing JB, Geva E
      Fertil. Steril., 2008;89(4):922-6.
    46. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane.
      Authors: Burstein HJ, Elias AD, Rugo HS, Cobleigh MA, Wolff AC, Eisenberg PD, Lehman M, Adams BJ, Bello CL, DePrimo SE, Baum CM, Miller KD
      J. Clin. Oncol., 2008;26(11):1810-6.
      Species: Human
      Sample Type: Plasma
    47. Comparison of bevacizumab, ranibizumab, and pegaptanib in vitro: efficiency and possible additional pathways.
      Authors: Klettner A, Roider J
      Invest. Ophthalmol. Vis. Sci., 2008;49(10):4523-7.
      Species: Porcine
      Sample Type: Cell Culture Supernates
    48. Early vascular and neuronal changes in a VEGF transgenic mouse model of retinal neovascularization.
      Authors: van Eeden PE, Tee LB, Lukehurst S, Lai CM, Rakoczy EP, Beazley LD, Dunlop SA
      Invest. Ophthalmol. Vis. Sci., 2006;47(10):4638-45.
      Species: Human
      Sample Type: ocular fluid
    49. Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines.
      Authors: Simiantonaki N, Jayasinghe C, Michel-Schmidt R, Peters K, Hermanns MI, Kirkpatrick CJ
      Int. J. Oncol., 2008;32(3):585-92.
    50. Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma.
      Authors: Kleinman ME, Greives MR, Churgin SS, Blechman KM, Chang EI, Ceradini DJ, Tepper OM, Gurtner GC
      Arterioscler. Thromb. Vasc. Biol., 2007;27(12):2664-70.
      Species: Human
      Sample Type: Plasma
    51. Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs.
      Authors: Hirata A, Minamino T, Asanuma H, Fujita M, Wakeno M, Myoishi M, Tsukamoto O, Okada K, Koyama H, Komamura K, Takashima S, Shinozaki Y, Mori H, Shiraga M, Kitakaze M, Hori M
      J. Am. Coll. Cardiol., 2006;48(1):176-84.
      Species: Canine
      Sample Type: Plasma
    52. Marrow angiogenesis-associated factors as prognostic biomarkers in patients with acute myelogenous leukaemia.
      Authors: Lee CY, Tien HF, Hu CY, Chou WC, Lin LI
      Br. J. Cancer, 2007;97(7):877-82.
      Species: Human
      Sample Type: Plasma
    53. Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy.
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      Species: Human
      Sample Type: Plasma
    54. Mesenchymal stem cells support migration, extracellular matrix invasion, proliferation, and survival of endothelial cells in vitro.
      Authors: Potapova IA, Gaudette GR, Brink PR, Robinson RB, Rosen MR, Cohen IS, Doronin SV
      Stem Cells, 2007;25(7):1761-8.
      Species: Human
      Sample Type: Cell Culture Supernates
    55. Airway remodeling and lack of bronchodilator response in steroid-resistant asthma.
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      J. Allergy Clin. Immunol., 2007;120(5):1065-72.
      Species: Human
      Sample Type: BALF
    56. Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression.
      Authors: Wanami LS, Chen HY, Peiro S, Garcia de Herreros A, Bachelder RE
      Exp. Cell Res., 2008;314(13):2448-53.
      Species: Human
      Sample Type: Cell Lysates
    57. Roles of angiopoietin-1 and angiopoietin-2 on airway microvascular permeability in asthmatic patients.
      Authors: Kanazawa H, Nomura S, Asai K
      Chest, 2007;131(4):1035-41.
      Species: Human
      Sample Type: Sputum
    58. Effects of simvastatin on angiogenic growth factors released at the site of microvascular injury.
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      Thromb. Haemost., 2006;95(6):1045-7.
    59. Increased circulating endothelial progenitor cells in septic patients: correlation with survival.
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      Crit. Care Med., 2007;35(7):1677-84.
      Species: Human
      Sample Type: Serum
    60. Clinical factors related to the aqueous levels of vascular endothelial growth factor and hepatocyte growth factor in proliferative diabetic retinopathy.
      Authors: Shinoda K, Ishida S, Kawashima S, Wakabayashi T, Uchita M, Matsuzaki T, Takayama M, Shinmura K, Yamada M
      Curr. Eye Res., 2000;21(2):655-61.
      Species: Human
      Sample Type: Aqueous humor
    61. Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease.
      Authors: Findley CM, Mitchell RG, Duscha BD, Annex BH, Kontos CD
      J. Am. Coll. Cardiol., 2008;52(5):387-93.
      Species: Human
      Sample Type: Plasma
    62. A phase I biological and pharmacologic study of the heparanase inhibitor PI-88 in patients with advanced solid tumors.
      Authors: Basche M, Gustafson DL, Holden SN, O'Bryant CL, Gore L, Witta S, Schultz MK, Morrow M, Levin A, Creese BR, Kangas M, Roberts K, Nguyen T, Davis K, Addison RS, Moore JC, Eckhardt SG
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      Species: Human
      Sample Type: Plasma
    63. Vascular remodeling is a feature of asthma and nonasthmatic eosinophilic bronchitis.
      Authors: Siddiqui S, Sutcliffe A, Shikotra A, Woodman L, Doe C, McKenna S, Wardlaw A, Bradding P, Pavord I, Brightling C
      J. Allergy Clin. Immunol., 2007;120(4):813-9.
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      Sample Type: Sputum
    64. Angiogenic balance in human melanoma: expression of VEGF, bFGF, IL-8, PDGF and angiostatin in relation to vascular density of xenografts in vivo.
      Authors: Westphal JR, Van't Hullenaar R, Peek R, Willems RW, Crickard K, Crickard U, Askaa J, Clemmensen I, Ruiter DJ, De Waal RM
      Int. J. Cancer, 2000;86(6):768-76.
    65. Phase I clinical and pharmacodynamic evaluation of oral CI-1033 in patients with refractory cancer.
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      Species: Human
      Sample Type: Plasma
    66. Growth factors and proinflammatory cytokines in the renal involvement of POEMS syndrome.
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      Am. J. Kidney Dis., 1999;34(4):633-8.
      Species: Human
      Sample Type: Serum
    67. Urine vascular endothelial growth factor-A is not a useful marker for endometriosis.
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      Fertil. Steril., 2004;81(6):1507-12.
      Species: Human
      Sample Type: Urine
    68. Changes in the circulating plasma levels of VEGF and VEGF-D after adjuvant chemotherapy in patients with breast cancer and 1 to 3 positive lymph nodes.
      Authors: Kummel S, Eggemann H, Luftner D, Thomas A, Jeschke S, Zerfel N, Heilmann V, Emons G, Zeiser T, Ulm K, Kobl M, Korlach S, Schmid P, Sehouli J, Elling D, Blohmer JU
      Anticancer Res., 2006;26(2):1719-26.
      Species: Human
      Sample Type: Plasma
    69. Conduction performance of collateral vessels induced by vascular endothelial growth factor or basic fibroblast growth factor.
      Authors: Kondoh K, Koyama H, Miyata T, Takato T, Hamada H, Shigematsu H
      Cardiovasc. Res., 2004;61(1):132-42.
      Species: Rabbit
      Sample Type: Cell Culture Supernates
    70. Electromagnetic guidance for catheter-based transendocardial injection: a platform for intramyocardial angiogenesis therapy. Results in normal and ischemic porcine models.
      Authors: Kornowski R, Leon MB, Fuchs S, Vodovotz Y, Flynn MA, Gordon DA, Pierre A, Kovesdi I, Keiser JA, Epstein SE
      J. Am. Coll. Cardiol., 2000;35(4):1031-9.
      Species: Porcine
      Sample Type: Tissue Homogenates
    71. Serum levels of syndecan-1 in B-cell chronic lymphocytic leukemia: correlation with the extent of angiogenesis and disease-progression risk in early disease.
      Authors: Molica S, Vitelli G, Mirabelli R, Digiesu G, Giannarelli D, Cuneo A, Ribatti D, Vacca A
      Leuk. Lymphoma, 2006;47(6):1034-40.
      Species: Human
      Sample Type: Serum
    72. Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities.
      Authors: Pang L, Nie M, Corbett L, Sutcliffe A, Knox AJ
      J. Immunol., 2006;176(6):3788-95.
      Species: Human
      Sample Type: Cell Culture Supernates
    73. Antioxidant intervention prevents renal neovascularization in hypercholesterolemic pigs.
      Authors: Chade AR, Bentley MD, Zhu X, Rodriguez-Porcel M, Niemeyer S, Amores-Arriaga B, Napoli C, Ritman EL, Lerman A, Lerman LO
      J. Am. Soc. Nephrol., 2004;15(7):1816-25.
      Species: Porcine
      Sample Type: Tissue Homogenates
    74. Phase I clinical and pharmacokinetic study of PTK/ZK, a multiple VEGF receptor inhibitor, in patients with liver metastases from solid tumours.
      Authors: Mross K, Drevs J, Muller M, Medinger M, Marme D, Hennig J, Morgan B, Lebwohl D, Masson E, Ho YY, Gunther C, Laurent D, Unger C
      Eur. J. Cancer, 2005;41(9):1291-9.
      Species: Human
      Sample Type: Plasma
    75. High basic fibroblast growth factor levels in nipple aspirate fluid are correlated with breast cancer.
      Authors: Hsiung R, Zhu W, Klein G, Qin W, Rosenberg A, Park P, Rosato E, Sauter E
      Cancer J, 2002;8(4):303-10.
      Species: Human
      Sample Type: Nipple aspirate fluid
    76. Significant decrease in angiopoietin-1 and angiopoietin-2 after radical prostatectomy in prostate cancer patients.
      Authors: Caine GJ, Ryan P, Lip GY, Blann AD
      Cancer Lett., 2007;251(2):296-301.
      Species: Human
      Sample Type: Plasma
    77. Hyperbaric oxygen and ovarian follicular stimulation for in vitro fertilization: a pilot study.
      Authors: Van Voorhis BJ, Greensmith JE, Dokras A, Sparks AE, Simmons ST, Syrop CH
      Fertil. Steril., 2005;83(1):226-8.
      Species: Human
      Sample Type: Follicular Fluid
    78. A potential role for vascular endothelial growth factor-D as an autocrine growth factor for human breast carcinoma cells.
      Authors: Akahane M, Akahane T, Shah A, Okajima E, Thorgeirsson UP
      Anticancer Res., 2005;25(2):701-7.
    79. Neoadjuvant therapy and biliary decompression lower biliary and pancreatic juice vascular endothelial growth factor levels in patients with periampullary adenocarcinoma.
      Authors: Berger AC, Watson JC, Ross EA, Zalatoris A, Hoffman JP
      Am Surg, 2004;70(2):169-73; discu.
    80. Cerebrospinal fluid vascular endothelial growth factor in patients with amyotrophic lateral sclerosis.
      Authors: Ilzecka J
      Clin Neurol Neurosurg, 2004;106(4):289-93.
      Species: Human
      Sample Type: CSF
    81. Vascular endothelial growth factor (VEGF) levels as a tool to discriminate between malignant and nonmalignant ascites.
      Authors: Nascimento I, Schaer R, Lemaire D, Freire S, Paule B, Carvalho S, Meyer R, Schaer-Barbosa H
      APMIS, 2004;112(9):585-7.
      Species: Human
      Sample Type: Ascites
    82. High altitude training of dogs results in elevated erythropoietin and endothelin-1 serum levels.
      Authors: Glaus TM, Grenacher B, Koch D, Reiner B, Gassmann M
      Comp. Biochem. Physiol., Part A Mol. Integr. Physiol., 2004;138(3):355-61.
      Species: Canine
      Sample Type: Serum
    83. Vascular endothelial growth factor is increased in cerebrospinal fluid after traumatic brain injury in infants and children.
      Authors: Shore PM, Jackson EK, Wisniewski SR, Clark RS, Adelson PD, Kochanek PM
      Neurosurgery, 2004;54(3):605-11; discu.
      Species: Human
      Sample Type: CSF
    84. Elevated erythropoietin in vitreous with ischemic retinal diseases.
      Authors: Inomata Y, Hirata A, Takahashi E, Kawaji T, Fukushima M, Tanihara H
      Neuroreport, 2004;15(5):877-9.
    85. Vascular endothelial growth factor (VEGF) concentration in sera and tumor effusions from patients with ovarian carcinoma.
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      Anticancer Res., 2004;24(2):1149-57.
    86. Follicular blood flow is a better predictor of the outcome of in vitro fertilization-embryo transfer than follicular fluid vascular endothelial growth factor and nitric oxide concentrations.
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      Fertil. Steril., 2004;82(3):586-92.
      Species: Human
      Sample Type: Follicular Fluid
    87. Plasma and urinary vascular endothelial growth factor and diabetic nephropathy in Type 2 diabetes mellitus.
      Authors: Kim NH, Kim KB, Kim DL, Kim SG, Choi KM, Baik SH, Choi DS, Kang YS, Han SY, Han KH, Ji YH, Cha DR
      Diabet. Med., 2004;21(6):545-51.
    88. A potential pro-angiogenic cell therapy with human placenta-derived mesenchymal cells.
      Authors: Nishishita T, Ouchi K, Zhang X, Inoue M, Inazawa T, Yoshiura K, Kuwabara K, Nakaoka T, Watanabe N, Igura K, Takahashi TA, Yamashita N
      Biochem. Biophys. Res. Commun., 2004;325(1):24-31.
    89. Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy.
      Authors: Watanabe D, Suzuma K, Suzuma I, Ohashi H, Ojima T, Takagi H
      Am. J. Ophthalmol., 2005;139(3):476-81.
      Species: Human
      Sample Type: Vitreous Humor
    90. Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells: Involvement of cytosolic phospholipase A2 activity.
      Authors: Ottino P, Finley J, Rojo E, Ottlecz A, Lambrou GN, Bazan HE, Bazan NG
      Mol. Vis., 2004;10(0):341-50.
      Species: Primate - Macaca mulatta (Rhesus monkey)
      Sample Type: Cell Culture Supernates
    91. Amniotic levels of nitric oxide and vascular endothelial growth factor in pregnancy with subsequent intrauterine fetal death.
      Authors: Tranquilli AL, Giannubilo SR, Bezzeccheri V, Ciavattini A, Scagnoli C, Mazzanti L
      Eur. J. Obstet. Gynecol. Reprod. Biol., 2004;114(2):162-5.
      Species: Human
      Sample Type: Amniotic Fluid
    92. Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis.
      Authors: Masuyama H, Suwaki N, Nakatsukasa H, Masumoto A, Tateishi Y, Hiramatrsu Y
      Am. J. Obstet. Gynecol., 2006;194(2):551-6.
      Species: Human
      Sample Type: Serum
    93. Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy.
      Authors: Ogata N, Nishikawa M, Nishimura T, Mitsuma Y, Matsumura M
      Am. J. Ophthalmol., 2002;134(3):348-53.
      Species: Human
      Sample Type: Vitreous Humor
    94. Correlation of increased vascular endothelial growth factor with neovascularization and permeability in ischemic central vein occlusion.
      Authors: Boyd SR, Zachary I, Chakravarthy U, Allen GJ, Wisdom GB, Cree IA, Martin JF, Hykin PG
      Arch. Ophthalmol., 2002;120(12):1644-50.
    95. Antibody neutralization of vascular endothelial growth factor (VEGF) fails to attenuate vascular permeability and brain edema in experimental pneumococcal meningitis.
      Authors: van der Flier M, Coenjaerts FE, Mwinzi PN, Rijkers E, Ruyken M, Scharringa J, Kimpen JL, Hoepelman AI, Geelen SP
      J. Neuroimmunol., 2005;160(1):170-7.
    96. Clinicopathologic correlation of progressive fibrovascular proliferation associated with occult choroidal neovascularization in age-related macular degeneration.
      Authors: Csaky K, Baffi J, Chan CC, Byrnes GA
      Arch. Ophthalmol., 2004;122(4):650-2.
      Species: Human
      Sample Type: Subretinal fluid
    97. Changes in plasma vascular endothelial growth factor, angiopoietins, and their receptors following surgery for breast cancer.
      Authors: Caine GJ, Stonelake PS, Lip GY, Blann AD
      Cancer Lett., 2007;248(1):131-6.
      Species: Human
      Sample Type: Plasma
    98. Free insulin growth factor-I and vascular endothelial growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy.
      Authors: Simo R, Lecube A, Segura RM, Garcia Arumi J, Hernandez C
      Am. J. Ophthalmol., 2002;134(3):376-82.
    99. Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor.
      Authors: Norden-Zfoni A, Desai J, Manola J, Beaudry P, Force J, Maki R, Folkman J, Bello C, Baum C, DePrimo SE, Shalinsky DR, Demetri GD, Heymach JV
      Clin. Cancer Res., 2007;13(9):2643-50.
      Species: Human
      Sample Type: Plasma
    100. Reduced pericardial levels of endostatin correlate with collateral development in patients with ischemic heart disease.
      Authors: Panchal VR, Rehman J, Nguyen AT, Brown JW, Turrentine MW, Mahomed Y, March KL
      J. Am. Coll. Cardiol., 2004;43(8):1383-7.
      Species: Human
      Sample Type: Pericardial Fluid
    101. Follicular fluid concentrations of vascular endothelial growth factor, inhibin A and inhibin B in IVF cycles: are they markers for ovarian response and pregnancy outcome?
      Authors: Ocal P, Aydin S, Cepni I, Idil S, Idil M, Uzun H, Benian A
      Eur. J. Obstet. Gynecol. Reprod. Biol., 2004;115(2):194-9.
    102. Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer.
      Authors: Kut C, Mac Gabhann F, Popel AS
      Br. J. Cancer, 2007;97(7):978-85.
    103. Effects of pranlukast administration on vascular endothelial growth factor levels in asthmatic patients.
      Authors: Kanazawa H, Yoshikawa T, Hirata K, Yoshikawa J
      Chest, 2004;125(5):1700-5.
      Species: Human
      Sample Type: Saliva
    104. Structural stability of neoangiogenic intramyocardial microvessels supports functional recovery in chronic ischemic myocardium.
      Authors: Shim WS, Lim SY, Li SQ, Gu Y, Ong HC, Song IC, Chuah SC, Wong P
      J. Mol. Cell. Cardiol., 2008;45(1):70-80.
      Species: Porcine
      Sample Type: Tissue Homogenates
    105. Estrogen enhances angiogenesis through a pathway involving platelet-activating factor-mediated nuclear factor-kappaB activation.
      Authors: Seo KH, Lee HS, Jung B, Ko HM, Choi JH, Park SJ, Choi IH, Lee HK, Im SY
      Cancer Res., 2004;64(18):6482-8.
      Species: Human
      Sample Type: Cell Culture Supernates
    106. Imbalance between vascular endothelial growth factor and endostatin levels in induced sputum from asthmatic subjects.
      Authors: Asai K, Kanazawa H, Otani K, Shiraishi S, Hirata K, Yoshikawa J
      J. Allergy Clin. Immunol., 2002;110(4):571-5.
      Species: Human
      Sample Type: Sputum
    107. Vascular endothelial growth factor in pleural effusions of different origin.
      Authors: Sack U, Hoffmann M, Zhao XJ, Chan KS, Hui DS, Gosse H, Engelmann L, Schauer J, Emmrich F, Hoheisel G
      Eur. Respir. J., 2005;25(4):600-4.
    108. Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts.
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      Cancer Lett., 2002;185(1):31-7.
      Species: Human
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    109. Bi-directional cell contact-dependent regulation of gene expression between endothelial cells and osteoblasts in a three-dimensional spheroidal coculture model.
      Authors: Stahl A, Wenger A, Weber H, Stark GB, Augustin HG, Finkenzeller G
      Biochem. Biophys. Res. Commun., 2004;322(2):684-92.
    110. Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia.
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      Am. J. Obstet. Gynecol., 2005;192(3):734-41.
      Species: Human
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    112. Hypoxia-induced expression of VEGF is reversible in myocardial vascular smooth muscle cells.
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      Am. J. Physiol., 1997;273(2):H628-33.
      Species: Canine
      Sample Type: Cell Culture Supernates
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      Authors: Clifford CA, Hughes D, Beal MW, Henry CJ, Drobatz KJ, Sorenmo KU
      J. Vet. Intern. Med., 2002;16(2):164-8.
      Species: Canine
      Sample Type: Body effusions
    114. Nitric oxide and vascular endothelial growth factor concentrations are increased but not related in vitreous fluid of patients with proliferative diabetic retinopathy.
      Authors: Hernandez C, Lecube A, Segura RM, Sararols L, Simo R
      Diabet. Med., 2002;19(8):655-60.
    115. Relation of various plasma growth factor levels in patients with stable angina pectoris and total occlusion of a coronary artery to the degree of coronary collaterals.
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      Am. J. Cardiol., 2005;97(4):472-6.
      Species: Human
      Sample Type: Serum
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      J. Clin. Endocrinol. Metab., 2002;87(7):3300-8.
    117. Vascular endothelial growth factor (VEGF) and angiopoietin regulation by gonadotrophin and steroids in macaque granulosa cells during the peri-ovulatory interval.
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      Mol. Hum. Reprod., 1999;5(12):1115-21.
      Species: Primate - Macaca mulatta (Rhesus monkey)
      Sample Type: Follicular Fluid
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      Authors: Gu JW, Brady AL, Anand V, Moore MC, Kelly WC, Adair TH
      Am. J. Physiol., 1999;277(2):H595-602.
      Species: Canine
      Sample Type: Cell Culture Supernates
    119. Role of serum VEGFA, TIMP2, MMP2 and MMP9 in monitoring response to adjuvant radiochemotherapy in patients with primary cervical cancer--results of a companion protocol of the randomized NOGGO-AGO phase III clinical trial.
      Authors: Braicu E, Gasimli K, Richter R, Nassir M, Kummel S, Blohmer J, Yalcinkaya I, Chekerov R, Ignat I, Ionescu A, Mentze M, Fotopoulou C, Pop C, Lichtenegger W, Sehouli J
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      Species: Human
      Sample Type: Serum
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      Am. J. Pathol., 2010;177(5):2268-77.
      Species: Human
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    121. Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells.
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      Lab. Invest., 2012;92(2):178-90.
      Species: Human
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      Cancer Res., 2006;66(13):6699-707.
      Species: Human
      Sample Type: Cell Culture Supernates
    123. Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study.
      Authors: Briasoulis, Evangelo, Aravantinos, Gerasimo, Kouvatseas, George, Pappas, Periklis, Biziota, Eirini, Sainis, Ioannis, Makatsoris, Thomas, Varthalitis, Ioannis, Xanthakis, Ioannis, Vassias, Antonios, Klouvas, George, Boukovinas, Ioannis, Fountzilas, George, Syrigos, Kostanti, Kalofonos, Haralamb, Samantas, Epaminon
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      Species: Human
      Sample Type: Plasma
    124. Vitreous VEGF clearance is increased after vitrectomy.
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      Invest. Ophthalmol. Vis. Sci., 2010;51(4):2135-8.
      Species: Rabbit
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    125. Met Receptor Tyrosine Kinase Signaling Induces Secretion of the Angiogenic Chemokine Interleukin-8/CXCL8 in Pancreatic Cancer.
      Authors: Hill KS, Gaziova I, Harrigal L
      PLoS ONE, 2012;7(7):e40420.
      Species: Human
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      Species: Human
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    127. Circulating angiogenic factors and the risk of preeclampsia.
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      N. Engl. J. Med., 2004;350(7):672-83.
      Species: Human
      Sample Type: Serum
    128. Hypoxia potentiates glioma-mediated immunosuppression.
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      PLoS ONE, 2012;6(1):e16195.
      Species: Human
      Sample Type: Cell Culture Supernates
    129. Improved prediction of disease relapse after radical prostatectomy through a panel of preoperative blood-based biomarkers.
      Authors: Shariat SF, Karam JA, Walz J, Roehrborn CG, Montorsi F, Margulis V, Saad F, Slawin KM, Karakiewicz PI
      Clin. Cancer Res., 2008;14(12):3785-91.
      Species: Human
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    130. Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells.
      Authors: Sreekumar PG, Kannan R, de Silva AT, Burton R, Ryan SJ, Hinton DR
      Biochem. Biophys. Res. Commun., 2006;346(4):1200-6.
      Species: Human
      Sample Type: Cell Culture Supernates
    131. Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities.
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      Blood, 2011;117(13):3485-93.
      Species: Human
      Sample Type: Plasma
    132. Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.
      Authors: Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S
      PLoS Pathog., 2012;8(1):e1002486.
      Species: Human
      Sample Type: Cell Culture Supernates
    133. Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair.
      Authors: Li TS, Cheng K, Malliaras K, Matsushita N, Sun B, Marban L, Zhang Y, Marban E
      Cardiovasc. Res., 2011;89(1):157-65.
      Species: Human
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    134. Over-expression of p53 mutants in LNCaP cells alters tumor growth and angiogenesis in vivo.
      Authors: Perryman LA, Blair JM, Kingsley EA, Szymanska B, Ow KT, Wen VW, MacKenzie KL, Vermeulen PB, Jackson P, Russell PJ
      Biochem. Biophys. Res. Commun., 2006;345(3):1207-14.
      Species: Human
      Sample Type: Cell Culture Supernates
    135. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome.
      Authors: Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ
      Am. J. Pathol., 2002;160(4):1405-23.
      Species: Human
      Sample Type: Cell Culture Supernates
    136. Age-dependent mobilization of circulating endothelial progenitor cells in infants and young children undergoing cardiac surgery with cardiopulmonary bypass.
      Authors: Sun Y, Yi D, Wang Y, Zheng R, Sun G, Wang J, Liu Y, Ren J, Wang Y, Zhang S, Gu C, Pei J
      Cytokine, 2009;47(3):206-13.
      Species: Human
      Sample Type: Plasma
    137. The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection.
      Authors: Asimakopoulos B, Abu-Hassan D, Metzen E, Al-Hasani S, Diedrich K, Nikolettos N
      Fertil. Steril., 2007;90(1):60-4.
      Species: Human
      Sample Type: Follicular Fluid
    138. Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.
      Authors: Meda C, Molla F, De Pizzol M
      J. Immunol., 2012;188(8):4081-92.
      Species: Human
      Sample Type: Cell Culture Supernates
    139. Vascular endothelial growth factor modulates matrix metalloproteinase-9 expression in asthma.
      Authors: Lee KS, Min KH, Kim SR, Park SJ, Park HS, Jin GY, Lee YC
      Am. J. Respir. Crit. Care Med., 2006;174(2):161-70.
    140. Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria.
      Authors: Yeo TW, Lampah DA, Gitawati R, Tjitra E, Kenangalem E, Piera K, Price RN, Duffull SB, Celermajer DS, Anstey NM
      Proc. Natl. Acad. Sci. U.S.A., 2008;105(44):17097-102.
      Species: Human
      Sample Type: Plasma
    141. Tissue engineering for full-thickness burns: a dermal substitute from bench to bedside.
      Authors: Kellouche S, Martin C, Korb G, Rezzonico R, Bouard D, Benbunan M, Dubertret L, Soler C, Legrand C, Dosquet C
      Biochem. Biophys. Res. Commun., 2007;363(3):472-8.
      Species: Human
      Sample Type: Cell Culture Supernates
    142. Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis.
      Authors: Ha CT, Wu JA, Irmak S, Lisboa FA, Dizon AM, Warren JW, Ergun S, Dveksler GS
      Biol. Reprod., 2010;83(1):27-35.
    143. WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells.
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      Mol Cancer, 2014;13(0):88.
      Species: Human
      Sample Type: cell culture supernate
    144. Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice.
      Authors: Kosugi T, Nakayama T, Li Q, Chiodo VA, Zhang L, Campbell-Thompson M, Grant M, Croker BP, Nakagawa T
      Am. J. Physiol. Renal Physiol., 2010;298(3):F609-16.
      Species: Human
      Sample Type: Serum
    145. Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma?
      Authors: Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P, Christiaans SC, Bir ND, Pittet JF
      Ann. Surg., 2008;247(2):320-6.
      Species: Human
      Sample Type: Plasma
    146. Cationic liposome coupled endostatin gene for treatment of peritoneal colon cancer.
      Authors: Lan KL, Ou-Yang F, Yen SH, Shih HL, Lan KH
      Clin. Exp. Metastasis, 2010;27(5):307-18.
    147. Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants.
      Authors: Fujinaga H, Baker CD, Ryan SL, Markham NE, Seedorf GJ, Balasubramaniam V, Abman SH
      Am. J. Physiol. Lung Cell Mol. Physiol., 2009;297(6):L1160-9.
      Species: Human
      Sample Type: Cell Culture Supernates
    148. Tumor necrosis factor alpha and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesis.
      Authors: Iversen PO, Wiig H
      Clin. Cancer Res., 2005;11(19):6793-9.
    149. Hepatocyte growth factor in the vitreous fluid of patients with proliferative diabetic retinopathy: its relationship with vascular endothelial growth factor and retinopathy activity.
      Authors: Simo R, Lecube A, Garcia-Arumi J, Carrasco E, Hernandez C
      Diabetes Care, 2004;27(1):287-8.
      Species: Human
      Sample Type: Vitreous Humor
    150. A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.
      Authors: Abuhusain, Hazem J, Matin, Azadeh, Qiao, Qiao, Shen, Han, Kain, Nupur, Day, Bryan W, Stringer, Brett W, Daniels, Benjamin, Laaksonen, Maarit A, Teo, Charlie, McDonald, Kerrie L, Don, Anthony
      J Biol Chem, 2013;288(52):37355-64.
      Species: Human
      Sample Type: Cell Culture Supernates
    151. Effect of platelet lysate on human cells involved in different phases of wound healing.
      Authors: Barsotti M, Losi P, Briganti E, Sanguinetti E, Magera A, Al Kayal T, Feriani R, Di Stefano R, Soldani G
      PLoS ONE, 2013;8(12):e84753.
      Species: Human
      Sample Type: Cell Lysate
    152. Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.
      Authors: Lederle W, Stark HJ, Skobe M, Fusenig NE, Mueller MM
      Am. J. Pathol., 2006;169(5):1767-83.
      Species: Human
      Sample Type: Cell Culture Supernates
    153. Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation.
      Authors: Coupel S, Moreau A, Hamidou M, Horejsi V, Soulillou JP, Charreau B
      Blood, 2007;109(7):2806-14.
      Species: Human
      Sample Type: Serum
    154. Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells.
      Authors: Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB
      Glia, 2006;53(8):845-57.
      Species: Human
      Sample Type: Cell Culture Supernates
    155. Systemic upregulation of PDGF-B in patients with neovascular AMD.
      Authors: Zehetner C, Kirchmair R, Neururer S, Kralinger M, Bechrakis N, Kieselbach G
      Invest Ophthalmol Vis Sci, 2014;55(1):337-44.
      Species: Human
      Sample Type: Plasma
    156. Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus.
      Authors: Nicoletti JN, Shah SK, McCloskey DP, Goodman JH, Elkady A, Atassi H, Hylton D, Rudge JS, Scharfman HE, Croll SD
      Neuroscience, 2007;151(1):232-41.
      Species: Rat
      Sample Type: Tissue Homogenates
    157. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy.
      Authors: Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z
      Nature, 2012;485(7398):333-8.
      Species: Human
      Sample Type: Plasma
    158. Designing nanotopographical density of extracellular matrix for controlled morphology and function of human mesenchymal stem cells.
      Authors: Kim J, Kim H, Lim K, Kim Y, Seonwoo H, Park S, Lim H, Kim D, Suh K, Choung P, Choung Y, Chung J
      Sci Rep, 2013;3(0):3552.
      Species: Human
      Sample Type: Cell Culture Supernates
    159. Intraperitoneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma.
      Authors: Marme A, Strauss G, Bastert G, Grischke EM, Moldenhauer G
      Int. J. Cancer, 2002;101(2):183-9.
      Species: Human
      Sample Type: Ascites
    160. Angiogenic growth factors in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction.
      Authors: Wallner W, Sengenberger R, Strick R, Strissel PL, Meurer B, Beckmann MW, Schlembach D
      Clin. Sci., 2007;112(1):51-7.
      Species: Human
      Sample Type: Serum
    161. Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
      Authors: Mabilleau G, Sabokbar A
      PLoS ONE, 2009;4(1):e4173.
      Species: Human
      Sample Type: Cell Culture Supernates
    162. Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood.
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      Infect. Immun., 2009;77(2):725-32.
      Species: Porcine
      Sample Type: Whole Blood
    163. Humoral and cellular factors responsible for coronary collateral formation.
      Authors: Sherman JA, Hall A, Malenka DJ, De Muinck ED, Simons M
      Am. J. Cardiol., 2006;98(9):1194-7.
      Species: Human
      Sample Type: Plasma
    164. Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors.
      Authors: Mahller YY, Vaikunth SS, Ripberger MC, Baird WH, Saeki Y, Cancelas JA, Crombleholme TM, Cripe TP
      Cancer Res., 2008;68(4):1170-9.
      Species: Human
      Sample Type: Plasma
    165. Have urinary levels of the angiogenic factors, basic fibroblast growth factor and vascular endothelial growth factor, a prognostic value in childhood acute lymphoblastic leukaemia?
      Authors: Schneider P, Vasse M, Legrand E, Callat MP, Vannier JP
      Br. J. Haematol., 2003;122(1):163-4.
      Species: Human
      Sample Type: Urine
    166. Serum neurotensin (NT) is increased in psoriasis and NT induces vascular endothelial growth factor release from human mast cells.
      Authors: Vasiadi M, Therianou A, Alysandratos KD, Katsarou-Katsari A, Petrakopoulou T, Theoharides A, Papadavid E, Stavrianeas N, Antoniou C, Kalogeromitros D, Theoharides TC
      Br. J. Dermatol., 2012;166(6):1349-52.
      Species: Human
      Sample Type: Cell Culture Supernates
    167. Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation.
      Authors: Herrmann S, Green J, Weber T, Scharfenberger A
      Bone, 2006;39(5):1156-63.
    168. Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients.
      Authors: van der Heijden M, van Nieuw Amerongen GP, Koolwijk P, van Hinsbergh VW, Groeneveld AB
      Thorax, 2008;63(10):903-9.
      Species: Human
      Sample Type: Plasma
    169. Pulmonary arterial hypertension and left-sided heart disease in sickle cell disease: clinical characteristics and association with soluble adhesion molecule expression.
      Authors: Klings ES, Anton Bland D, Rosenman D, Princeton S, Odhiambo A, Li G, Bernard SA, Steinberg MH, Farber HW
      Am. J. Hematol., 2008;83(7):547-53.
      Species: Human
      Sample Type: Plasma
    170. Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone.
      Authors: Brooks HL, Caballero S, Newell CK, Steinmetz RL, Watson D, Segal MS, Harrison JK, Scott EW, Grant MB
      Arch. Ophthalmol., 2004;122(12):1801-7.
      Species: Human
      Sample Type: Vitreous Humor
    171. The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584.
      Authors: Qian DZ, Wang X, Kachhap SK, Kato Y, Wei Y, Zhang L, Atadja P, Pili R
      Cancer Res., 2004;64(18):6626-34.
      Species: Human
      Sample Type: Cell Culture Supernates
    172. The change of cytokines in tear and blood after different pterygium operation.
      Authors: Lee JK, Song YS, Shin JS, Kwon YS, Shin MS, Kim JC
      Cytokine, 2010;49(2):148-54.
    173. A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway.
      Authors: Zhu W, Ou Y, Li Y, Xiao R, Shu M, Zhou Y, Xie J, He S, Qiu P, Yan G
      Mol. Pharmacol., 2009;75(4):812-9.
      Species: Human
      Sample Type: Cell Culture Supernates
    174. Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9).
      Authors: Santhekadur PK, Gredler R, Chen D
      J. Biol. Chem., 2012;287(5):3425-32.
      Species: Human
      Sample Type: Cell Culture Supernates
    175. Transcriptional repression of VEGF by ZNF24: mechanistic studies and vascular consequences in vivo.
      Authors: Jia, Di, Hasso, Sean M, Chan, Joanne, Filingeri, Domenic, D'Amore, Patricia, Rice, Lori, Pampo, Christin, Siemann, Dietmar, Zurakowski, David, Rodig, Scott J, Moses, Marsha A
      Blood, 2013;121(4):707-15.
      Species: Human
      Sample Type: Cell Culture Supernates
    176. Endometrial NK cells are special immature cells that await pregnancy.
      Authors: Manaster I, Mizrahi S, Goldman-Wohl D, Sela HY, Stern-Ginossar N, Lankry D, Gruda R, Hurwitz A, Bdolah Y, Haimov-Kochman R, Yagel S, Mandelboim O
      J. Immunol., 2008;181(3):1869-76.
      Species: Human
      Sample Type: Cell Culture Supernates
    177. The role of SDF-1-CXCR4/CXCR7 axis in biological behaviors of adipose tissue-derived mesenchymal stem cells in vitro.
      Authors: Li Q, Zhang A, Tao C, Li X, Jin P
      Biochem Biophys Res Commun, 2013;441(3):675-80.
      Species: Human
      Sample Type: Cell Culture Supernates
    178. Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma.
      Authors: Llovet JM, Pena CE, Lathia CD, Shan M, Meinhardt G, Bruix J, Pallota MG, Zarba JJ, Boyer M, Riordan S, Strickland A, Tebbutt N, Thomson B, Borbath I, De Greve J, Van Laethem J-, Van Steenbergen W, Van Vlierberghe H, Barrios C, Cosme de Oliveira A, Kotzev I, Takov D, Tchernev K, Burak K, Ma M, Metrakos P, Olweny C, Sherman M, Gamargo Garate C, Martinez-Castillo J, Beaugrand M, Bennouna J, Blanc J-, Bronowicki J-, Degos F, Dominguez S, Grange J-, Hillon P, Raoul J-, Seitz J-, Blum H, Buggisch P, Caspary W, Dollinger M, Gerken G, Goke B, Gregor M, Greten T, Haussinger D, Hilgard P, Scherübl J, Scheulen M, Schmid R, Spengler U, Wiest R, Zeuzem S, Arvanitakis C, Germanidis G, Katsos I, Figer A, Stemmer S, Amadori D, Bolondi L, Cognetti F, Craxi A, Farinati F, Gridelli C, Martoni A, Mazzaferro V, Porta C, Ricci S, Sangiovanni A, Santoro A, Trevisani F, Cisnero Garza LE, Gane E, O'Donnell A, Leon J, Lozano A, Jassem J, Rydzewska G, Szawlowski A, Tomczak P, Badulescu F, Miron L, Kubyshkin V, Bruix J, Forner A, Bustamante Schneider J, Diago M, Montero Alvarez JL, Pascual S, Ruíz del Arbol L, Sangro B, Solá R, Tabernero J, Muellhaupt B, Roth A, Jeffry Evans TR, Falk S, Meyer T, Reeves H, Ross P, Befeler A, Boyer T, Britten C, Byrne T, Garcia-Tsao G, Gold P, Goldenberg A, Heuman D, Kennedy P, Koch A, Llovet JM, Marrero J, Schilsky M, Schwartz J, Schwartz M
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      Species: Human
      Sample Type: Plasma
    179. Evaluation of a xenogeneic VEGF vaccine in dogs with soft tissue sarcoma.
      Authors: Kamstock D, Elmslie R, Thamm D
      Cancer Immunol. Immunother., 2007;56(8):1299-309.
      Species: Canine
      Sample Type: Plasma
    180. Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia.
      Authors: Maffei R, Martinelli S, Santachiara R
      Blood, 2010;116(4):584-92.
      Species: Human
      Sample Type: Plasma
    181. VEGF-A, VEGF-C, and VEGF-D in colorectal cancer progression.
      Authors: George ML, Tutton MG, Janssen F, Arnaout A, Abulafi AM, Eccles SA, Swift RI
      Neoplasia, 2001;3(5):420-7.
      Species: Human
      Sample Type: Tissue Homogenates
    182. Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function.
      Authors: Marcondes AM, Mhyre AJ, Stirewalt DL, Kim SH, Dinarello CA, Deeg HJ
      Proc. Natl. Acad. Sci. U.S.A., 2008;105(8):2865-70.
    183. The contributions of HIF-target genes to tumor growth in RCC.
      Authors: Zhang, Ting, Niu, Xiaohua, Liao, Lili, Cho, Eun-Ah, Yang, Haifeng
      PLoS ONE, 2013;8(11):e80544.
      Species: Human
      Sample Type: Cell Lysate
    184. Cardiac expression of placental growth factor predicts the improvement of chronic phase left ventricular function in patients with acute myocardial infarction.
      Authors: Iwama H, Uemura S, Naya N, Imagawa K, Takemoto Y, Asai O, Onoue K, Okayama S, Somekawa S, Kida Y, Takeda Y, Nakatani K, Takaoka M, Kawata H, Horii M, Nakajima T, Doi N, Saito Y
      J. Am. Coll. Cardiol., 2006;47(8):1559-67.
      Species: Human
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    185. Celecoxib up-regulates the expression of the zeta chain of T cell receptor complex in tumor-infiltrating lymphocytes in human cervical cancer.
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      Clin. Cancer Res., 2006;12(7):2055-60.
      Species: Human
      Sample Type: Serum
    186. Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.
      Authors: Volkova E, Willis JA, Wells JE, Robinson BA, Dachs GU, Currie MJ
      Br. J. Cancer, 2011;104(1):51-9.
      Species: Human
      Sample Type: Serum
    187. Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas.
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      Cancer Res., 2005;65(16):7241-8.
      Species: Human
      Sample Type: Cell Culture Supernates
    188. Serum levels of beta-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma.
      Authors: Zekri A, Bahnassy A, Alam El-Din H, Morsy H, Shaarawy S, Moharram N, Daoud S
      Oncol Rep, 2011;26(4):825-31.
      Species: Human
      Sample Type: Serum
    189. Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation.
      Authors: Zhang H, Fagan DH, Zeng X
      Oncogene, 2010;29(17):2517-27.
      Species: Human
      Sample Type: Cell Culture Supernates
    190. Cytokine secretion by human mesenchymal stem cells cocultured with damaged corneal epithelial cells.
      Authors: Oh JY, Kim MK, Shin MS, Wee WR, Lee JH
      Cytokine, 2009;46(1):100-3.
    191. Endostatin variations in childhood acute lymphoblastic leukaemia--comparison with basic fibroblast growth factor and vascular endothelial growth factor.
      Authors: Schneider P, Vasse M, Corbiere C, Legrand E, Marie-Cardine A, Boquet C, Cazin L, Vannier JP
      Leuk. Res., 2007;31(5):629-38.
    192. Leptin administered in physiological or pharmacological doses does not regulate circulating angiogenesis factors in humans.
      Authors: Aronis KN, Diakopoulos KN, Fiorenza CG
      Diabetologia, 2011;54(9):2358-67.
      Species: Human
      Sample Type: Serum
    193. Tumor necrosis factor alpha as a new target for renal cell carcinoma: two sequential phase II trials of infliximab at standard and high dose.
      Authors: Harrison ML, Obermueller E, Maisey NR, Hoare S, Edmonds K, Li NF, Chao D, Hall K, Lee C, Timotheadou E, Charles K, Ahern R, King DM, Eisen T, Corringham R, DeWitte M, Balkwill F, Gore M
      J. Clin. Oncol., 2007;25(29):4542-9.
      Species: Human
      Sample Type: Plasma
    194. Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors.
      Authors: Nilsson MB, Zage PE, Zeng L, Xu L, Cascone T, Wu HK, Saigal B, Zweidler-McKay PA, Heymach JV
      Oncogene, 2010;29(20):2938-49.
    195. Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy.
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      Clin. Cancer Res., 2009;15(14):4589-99.
    196. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.
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      J. Clin. Invest., 2003;111(5):649-58.
      Species: Human
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    197. Metabolic impact of anti-angiogenic agents on U87 glioma cells.
      Authors: Mesti T, Savarin P, Triba M, Le Moyec L, Ocvirk J, Banissi C, Carpentier A
      PLoS ONE, 2014;9(6):e99198.
      Species: Human
      Sample Type: cell culture supernate
    198. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms.
      Authors: Roorda BD, Ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Kamps WA, de Bont ES
      Eur. J. Cancer, 2010;46(5):974-82.
      Species: Human
      Sample Type: Plasma
    199. Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation.
      Authors: Hsu MY, Rovinsky SA, Lai CY, Qasem S, Liu X, How J, Engelhardt JF, Murphy GF
      Lab. Invest., 2008;88(8):842-55.
      Species: Human
      Sample Type: Cell Lysates
    200. Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy.
      Authors: Westerweel PE, Visseren FL, Hajer GR, Olijhoek JK, Hoefer IE, de Bree P, Rafii S, Doevendans PA, Verhaar MC
      Eur. Heart J., 2008;29(22):2808-17.
      Species: Human
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    201. Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth.
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      Cancer Res., 2007;67(2):593-9.
      Species: Human
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    202. PEDF derived from glial Muller cells: a possible regulator of retinal angiogenesis.
      Authors: Eichler W, Yafai Y, Keller T, Wiedemann P, Reichenbach A
      Exp. Cell Res., 2004;299(1):68-78.
      Species: Guinea Pig
      Sample Type: Cell Culture Supernates
    203. Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer.
      Clin. Cancer Res., 2012;18(18):5031-42.
    204. Late outgrowth endothelial progenitor cells in patients with age-related macular degeneration.
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      Invest. Ophthalmol. Vis. Sci., 2008;49(6):2696-708.
      Species: Human
      Sample Type: Plasma
    205. Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/Akt.
      Authors: Byeon SH, Lee SC, Choi SH, Lee HK, Lee JH, Chu YK, Kwon OW
      Invest. Ophthalmol. Vis. Sci., 2010;51(2):1190-7.
      Species: Human
      Sample Type: Cell Culture Supernates
    206. Serum concentrations of angiogenic cytokines in Waldenstrom macroglobulinaemia: the ration of angiopoietin-1 to angiopoietin-2 and angiogenin correlate with disease severity.
      Authors: Anagnostopoulos A, Eleftherakis-Papaiakovou V, Kastritis E, Tsionos K, Bamias A, Meletis J, Dimopoulos MA, Terpos E
      Br. J. Haematol., 2007;137(6):560-8.
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    207. Placental growth factor neutralising antibodies give limited anti-angiogenic effects in an in vitro organotypic angiogenesis model.
      Authors: Brave SR, Eberlein C, Shibuya M, Wedge SR, Barry ST
      Angiogenesis, 2010;13(4):337-47.
      Species: Human
      Sample Type: Cell Culture Supernates
    208. Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures.
      Authors: Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ
      Arthritis Rheum., 2006;54(10):3152-62.
      Species: Human
      Sample Type: Cell Culture Supernates
    209. Macrophage infiltration predicts a poor prognosis for human ewing sarcoma.
      Authors: Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
      Am. J. Pathol., 2011;179(3):1157-70.
    210. Long-term survival and biomarker correlates of tasquinimod efficacy in a multicenter randomized study of men with minimally symptomatic metastatic castration-resistant prostate cancer.
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      Clin Cancer Res, 2013;19(24):6891-901.
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      Sample Type: Plasma
    211. Plasma angiogenin levels in acute coronary syndromes: implications for prognosis.
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    212. Urinary biomarkers predict brain tumor presence and response to therapy.
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      Clin. Cancer Res., 2008;14(8):2378-86.
    213. Urinary placental growth factor and risk of preeclampsia.
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      Species: Human
      Sample Type: Cell Culture Supernates
    215. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
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    216. Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch.
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      Blood, 2010;116(16):2984-93.
    217. Relationship of soluble CD40 ligand to vascular endothelial growth factor, angiopoietins, and tissue factor in atrial fibrillation: a link among platelet activation, angiogenesis, and thrombosis?
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      Species: Human
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    218. Vascular endothelial growth factor drives autocrine epithelial cell proliferation and survival in chronic rhinosinusitis with nasal polyposis.
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      Am. J. Respir. Crit. Care Med., 2009;180(11):1056-67.
      Species: Human
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    219. Distraction osteogenesis induces endothelial progenitor cell mobilization without inflammatory response in man.
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      Bone, 2010;46(3):673-9.
      Species: Human
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    220. A phase II trial of single agent bevacizumab in patients with relapsed, aggressive non-Hodgkin lymphoma: Southwest oncology group study S0108.
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    221. Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid.
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      Sample Type: Cell Culture Supernates
    222. Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents.
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    223. Dendritic cells can turn CD4+ T lymphocytes into vascular endothelial growth factor-carrying cells by intercellular neuropilin-1 transfer.
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    224. Inflammation associated with obesity: relationship with blood and bone marrow endothelial cells.
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      Species: Human
      Sample Type: Plasma
    225. Inhibition of STAT3 reduces astrocytoma cell invasion and constitutive activation of STAT3 predicts poor prognosis in human astrocytoma.
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      Species: Human
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    226. VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma.
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    227. CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs.
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      Species: Porcine
      Sample Type: Plasma
    228. Tamoxifen and aromatase inhibitors differentially affect vascular endothelial growth factor and endostatin levels in women with breast cancer.
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    229. Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo.
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      Species: Human
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    230. Genetic and clinical factors influence the baseline permeability of the peritoneal membrane.
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    231. The potential of adiponectin in driving arthritis.
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    232. Ovariectomy increases mitogens and platelet-induced proliferation of arterial smooth muscle.
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      Species: Human
      Sample Type: Serum
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      Species: Human
      Sample Type: Serum
    235. Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes.
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      Species: Human
      Sample Type: Cell Culture Supernates
    236. Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts.
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      Stem Cells, 2007;25(8):1862-71.
      Species: Human
      Sample Type: Cell Culture Supernates
    237. A phase I trial of bortezomib with temozolomide in patients with advanced melanoma: toxicities, antitumor effects, and modulation of therapeutic targets.
      Authors: Su Y, Amiri KI, Horton LW
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      Species: Human
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    238. Thrombospondin-1 triggers cell migration and development of advanced prostate tumors.
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      Species: Human
      Sample Type: Cell Lysates
    239. The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis.
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      Blood, 2007;110(13):4464-75.
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      Sample Type: Plasma
    240. Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis.
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      Species: Human
      Sample Type: Serum
    241. Pertuzumab in combination with trastuzumab shows significantly enhanced antitumor activity in HER2-positive human gastric cancer xenograft models.
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      Clin. Cancer Res., 2011;17(15):5060-70.
      Species: Human
      Sample Type: Tissue Homogenates
    242. Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
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      Exp. Hematol., 2008;36(8):1035-46.
      Species: Human
      Sample Type: Cell Culture Supernates
    243. Alternatives to the use of fetal bovine serum: human platelet lysates as a serum substitute in cell culture media.
      Authors: Rauch C, Feifel E, Amann EM, Spotl HP, Schennach H, Pfaller W, Gstraunthaler G
      ALTEX, 2011;28(4):305-16.
      Species: Human
      Sample Type: Cell Lysates
    244. Neurotensin and CRH interactions augment human mast cell activation.
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      Species: Human
      Sample Type: Cell Culture Supernates
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