Inhibitor of Wnt processing and secretion. Inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β
-catenin accumulation. Suppresses self-renewal in R1 embryonic stem cells.
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All Tocris products are intended for laboratory research use only.
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling.
Lian et al.
Proc.Natl.Acad.Sci.U S A, 2012;109:E1848
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
Chen et al.
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells.
ten Berge et al.
The citations listed below are publications that use Tocris products. Selected citations for IWP 2 include:
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