IWP 2

  ( 18 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3533
Chemical Name:N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Product Details
Citations (18)
Reviews
Biological Activity
Inhibitor of Wnt processing and secretion. Inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. Suppresses self-renewal in R1 embryonic stem cells.
Technical Data
  • M.Wt:
    466.6
  • Formula:
    C22H18N4O2S3
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    686770-61-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for IWP 2 include:

18 Citations: Showing 1 - 10
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  1. A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells.
    Authors: Walko Et al.
    Nat Commun  2017;8:14744
  2. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.
    Authors: Lee Et al.
    Cell Stem Cell  2017;21:179
  3. Degree of tissue differentiation dictates susceptibility to BRAF-driven colorectal cancer.
    Authors: Tong
    Cell Rep  2017;21(13):3833
  4. Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
    Authors: Kennedy Et al.
    Proc Natl Acad Sci U S A  2016;113:3545
  5. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.
    Authors: Freedman Et al.
    Nat Cell Biol  2015;6:8715
  6. Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs.
    Authors: Lee Et al.
    Sci Rep  2015;5:11817
  7. A systems-biological study on the identification of safe and effective molecular targets for the reduction of ultraviolet B-induced skin pigmentation.
    Authors: Lee Et al.
    Nat Commun  2015;5:10305
  8. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
    Authors: Kumar Et al.
    Elife  2015;4
  9. Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales.
    Authors: Huebsch Et al.
    Tissue Eng Part C Methods  2015;21:467
  10. Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages.
    Authors: Ditadi Et al.
    Stem Cell Res  2015;17:580
  11. Supervised Machine Learning for Classification of the Electrophysiological Effects of Chronotropic Drugs on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
    Authors: Heylman Et al.
    PLoS One  2015;10:e0144572
  12. Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.
    Authors: Kim Et al.
    PLoS One  2015;10:e0118670
  13. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Sci Rep  2015;10:413
  14. Wnt/β-catenin signaling modulates human airway sensitization induced by β2-adrenoceptor stimulation.
    Authors: Faisy Et al.
    PLoS One  2014;9:e111350
  15. Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture.
    Authors: Kempf Et al.
    Stem Cell Reports  2014;3:1132
  16. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Nat Biotechnol  2014;32:84
  17. SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development.
    Authors: Skelton Et al.
    Nat Genet  2014;13:172
  18. Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium.
    Authors: Hojo Et al.
    J Biol Chem  2013;288:9924
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Average Rating: 5 (Based on 1 review)

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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