Catalog Number: 3533
Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Biological Activity
Inhibitor of Wnt processing and secretion. Inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. Suppresses self-renewal in R1 embryonic stem cells.
Technical Data
  • M.Wt:
    466.6
  • Formula:
    C22H18N4O2S3
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    686770-61-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling.
    Lian et al.
    Proc.Natl.Acad.Sci.U S A, 2012;109:E1848
  2. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
    Chen et al.
    Nat.Chem.Biol., 2009;5:100
  3. Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells.
    ten Berge et al.
    Nat.Cell.Biol., 2011;13:1070
Citations:

The citations listed below are publications that use Tocris products. Selected citations for IWP 2 include:

12 Citations: Showing 1 - 10
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  1. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.
    Authors: Freedman Et al.
    Nat Cell Biol 2015;6:8715
  2. Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs.
    Authors: Lee Et al.
    Sci Rep 2015;5:11817
  3. A systems-biological study on the identification of safe and effective molecular targets for the reduction of ultraviolet B-induced skin pigmentation.
    Authors: Lee Et al.
    Nat Commun 2015;5:10305
  4. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
    Authors: Kumar Et al.
    Elife 2015;4
  5. Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales.
    Authors: Huebsch Et al.
    Tissue Eng Part C Methods 2015;21:467
  6. Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages.
    Authors: Ditadi Et al.
    Stem Cell Res 2015;17:580
  7. Supervised Machine Learning for Classification of the Electrophysiological Effects of Chronotropic Drugs on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
    Authors: Heylman Et al.
    PLoS One 2015;10:e0144572
  8. Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.
    Authors: Kim Et al.
    PLoS One 2015;10:e0118670
  9. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Sci Rep 2015;10:413
  10. Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture.
    Authors: Kempf Et al.
    Stem Cell Reports 2014;3:1132
  11. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Nat Biotechnol 2014;32:84
  12. SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development.
    Authors: Skelton Et al.
    Nat Genet 2014;13:172
Expand to show all 12 Citations

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