Catalog Number: 3533
Chemical Name: N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
Biological Activity
Inhibitor of Wnt processing and secretion. Inactivates PORCN, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. Blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. Suppresses self-renewal in R1 embryonic stem cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling.
    Lian et al.
    Proc.Natl.Acad.Sci.U S A, 2012;109:E1848
  2. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
    Chen et al.
    Nat.Chem.Biol., 2009;5:100
  3. Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells.
    ten Berge et al.
    Nat.Cell.Biol., 2011;13:1070

The citations listed below are publications that use Tocris products. Selected citations for IWP 2 include:

Showing Results 1 - 10 of 12

  1. Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.
    Authors: Freedman Et al.
    Nat Cell Biol
  2. Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs.
    Authors: Lee Et al.
    Sci Rep
  3. A systems-biological study on the identification of safe and effective molecular targets for the reduction of ultraviolet B-induced skin pigmentation.
    Authors: Lee Et al.
    Nat Commun
  4. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells.
    Authors: Kumar Et al.
  5. Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales.
    Authors: Huebsch Et al.
    Tissue Eng Part C Methods
  6. Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages.
    Authors: Ditadi Et al.
    Stem Cell Res
  7. Supervised Machine Learning for Classification of the Electrophysiological Effects of Chronotropic Drugs on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
    Authors: Heylman Et al.
    PLoS One
  8. Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.
    Authors: Kim Et al.
    PLoS One
  9. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Sci Rep
  10. Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture.
    Authors: Kempf Et al.
    Stem Cell Reports
  11. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Nat Biotechnol
  12. SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development.
    Authors: Skelton Et al.
    Nat Genet
Expand to show all
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information