Human HNF-4 alpha/NR2A1 Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
Background: HNF-4 alpha/NR2A1
Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha; NR2A1) is a member of the orphan nuclear receptor family. HNF4 alpha is expressed in the liver, kidney, intestine and pancreas. Mutation of HNF4 alpha in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4 alpha gene is alternatively spliced and may generate up to nine different isoforms, HNF4 alpha 1 through HNF4 alpha 9. The expression of HNF-4 gamma (NR2A2) is observed in the pancreas, kidney, small intestine, and testes with no expression detected in the liver. The level of HNF-4 gamma is less 10% than that of HNF-4 alpha.
Product Datasheets
Citations for Human HNF-4 alpha/NR2A1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
5
Citations: Showing 1 - 5
Filter your results:
Filter by:
-
A hepatoprotective role of peritumoral non-parenchymal cells in early liver tumorigenesis
Authors: C Tian, L Li, L Fan, A Brown, EJ Norris, M Morrison, ES Glazer, L Zhu
Disease Models & Mechanisms, 2023-03-09;0(0):.
Species: Transgenic Mouse
Sample Types: Spheroid
Applications: IHC -
Genomic variants link to hepatitis C racial disparities
Authors: MM Yeh, S Boukhar, B Roberts, N Dasgupta, SS Daoud
Oncotarget, 2017-08-01;8(35):59455-59475.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors
Authors: PB Ancey, S Ecsedi, MP Lambert, FR Talukdar, MP Cros, D Glaise, DM Narvaez, V Chauvet, Z Herceg, A Corlu, H Hernandez-
Stem Cell Reports, 2017-06-22;0(0):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Mutant IDH inhibits HNF-4alpha to block hepatocyte differentiation and promote biliary cancer.
Authors: Saha S, Parachoniak C, Ghanta K, Fitamant J, Ross K, Najem M, Gurumurthy S, Akbay E, Sia D, Cornella H, Miltiadous O, Walesky C, Deshpande V, Zhu A, Hezel A, Yen K, Straley K, Travins J, Popovici-Muller J, Gliser C, Ferrone C, Apte U, Llovet J, Wong K, Ramaswamy S, Bardeesy N
Nature, 2014-07-02;513(7516):110-4.
Species: Mouse
Sample Types: Cell Lysates, Whole Tissue
Applications: IHC, Western Blot -
Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for notch signaling.
Authors: Fabris L, Cadamuro M, Guido M, Spirli C, Fiorotto R, Colledan M, Torre G, Alberti D, Sonzogni A, Okolicsanyi L, Strazzabosco M
Am. J. Pathol., 2007-06-28;171(2):641-53.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsIsotype Controls
Secondary Antibodies
Reviews for Human HNF-4 alpha/NR2A1 Antibody
Average Rating: 5 (Based on 2 Reviews)
Have you used Human HNF-4 alpha/NR2A1 Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
