Human HNF-4 alpha/NR2A1 Antibody
Human HNF-4 alpha/NR2A1 Antibody Summary
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
Background: HNF-4 alpha/NR2A1
Hepatocyte Nuclear Factor 4 alpha (HNF4 alpha; NR2A1) is a member of the orphan nuclear receptor family. HNF4 alpha is expressed in the liver, kidney, intestine and pancreas. Mutation of HNF4 alpha in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4 alpha gene is alternatively spliced and may generate up to nine different isoforms, HNF4 alpha 1 through HNF4 alpha 9. The expression of HNF-4 gamma (NR2A2) is observed in the pancreas, kidney, small intestine, and testes with no expression detected in the liver. The level of HNF-4 gamma is less 10% than that of HNF-4 alpha.
Citations for Human HNF-4 alpha/NR2A1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 5
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A hepatoprotective role of peritumoral non-parenchymal cells in early liver tumorigenesis
Authors: C Tian, L Li, L Fan, A Brown, EJ Norris, M Morrison, ES Glazer, L Zhu
Disease Models & Mechanisms, 2023-03-09;0(0):.
Species: Transgenic Mouse
Sample Types: Spheroid
Genomic variants link to hepatitis C racial disparities
Authors: MM Yeh, S Boukhar, B Roberts, N Dasgupta, SS Daoud
Sample Types: Whole Tissue
TET-Catalyzed 5-Hydroxymethylation Precedes HNF4A Promoter Choice during Differentiation of Bipotent Liver Progenitors
Authors: PB Ancey, S Ecsedi, MP Lambert, FR Talukdar, MP Cros, D Glaise, DM Narvaez, V Chauvet, Z Herceg, A Corlu, H Hernandez-
Stem Cell Reports, 2017-06-22;0(0):.
Sample Types: Cell Lysates
Applications: Western Blot
Mutant IDH inhibits HNF-4alpha to block hepatocyte differentiation and promote biliary cancer.
Authors: Saha S, Parachoniak C, Ghanta K, Fitamant J, Ross K, Najem M, Gurumurthy S, Akbay E, Sia D, Cornella H, Miltiadous O, Walesky C, Deshpande V, Zhu A, Hezel A, Yen K, Straley K, Travins J, Popovici-Muller J, Gliser C, Ferrone C, Apte U, Llovet J, Wong K, Ramaswamy S, Bardeesy N
Sample Types: Cell Lysates, Whole Tissue
Applications: IHC, Western Blot
Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for notch signaling.
Authors: Fabris L, Cadamuro M, Guido M, Spirli C, Fiorotto R, Colledan M, Torre G, Alberti D, Sonzogni A, Okolicsanyi L, Strazzabosco M
Am. J. Pathol., 2007-06-28;171(2):641-53.
Sample Types: Whole Tissue
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