Mouse Integrin  alpha 3/CD49c Antibody

Catalog # Availability Size / Price Qty
AF2787
AF2787-SP
Product Details
Citations (6)
FAQs
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Mouse Integrin  alpha 3/CD49c Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse Integrin alpha 3/CD49c in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human (rh) Integrin alpha 3 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse Integrin alpha 3/CD49c
Phe33-Glu993
Accession # Q62470
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse Integrin  alpha 3/CD49c
Flow Cytometry
0.25 µg/106 cells
XB2 mouse teratoma keratinocyte cell line
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Integrin alpha 3/CD49c

Integrin alpha 3, also known as CD49c and VLA-3 alpha, is a type I membrane protein that heterodimerizes with Integrin beta 1. alpha 3 beta 1 is a cell surface adhesion molecule that functions as a receptor for laminin, fibronectin, collagen, epiligrin, thrombospondin and chondroitin sulfate proteoglycan 4. The extracellular domain of human and mouse Integrin alpha 3 share approximately 87% amino acid sequence homology.

Entrez Gene IDs
3675 (Human); 16400 (Mouse)
Alternate Names
antigen identified by monoclonal J143; CD49 antigen-like family member C; CD49c antigen; CD49c; FLJ34631; FLJ34704; FRP-2; Galactoprotein B3; GAP-B3; GAPB3CD49C; Integrin alpha 3; integrin alpha-3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); ITGA3; MSK18; VCA-2; very late activation protein 3 receptor, alpha-3 subunit; VL3A; VLA-3 subunit alpha; VLA3a

Product Datasheets

Citations for Mouse Integrin  alpha 3/CD49c Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. Activated Protein C Attenuates Severe Inflammation by Targeting VLA-3(high) Neutrophil Subpopulation in Mice
    Authors: PP Sarangi, HW Lee, YV Lerman, A Trzeciak, EJ Harrower, AR Rezaie, M Kim
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow
  2. Integrin alpha6 maintains the structural integrity of the kidney collecting system
    Authors: Olga M Viquez
    Matrix Biol, 2016;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: WB
  3. Signaling events mediated by alpha3beta1 integrin are essential for mammary tumorigenesis.
    Authors: Cagnet S, Faraldo M, Kreft M, Sonnenberg A, Raymond K, Glukhova M
    Oncogene, 2014;33(34):4286-95.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: WB
  4. Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin alpha6beta1-ADAM17/tumor necrosis factor-alpha-converting enzyme (TACE) signaling pathway.
    Authors: Wang Y, Huang Z, Nayak P, Matthews B, Warburton D, Shi W, Sanchez-Esteban J
    J Biol Chem, 2013;288(35):25646-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neut
  5. Gain of glycosylation in integrin alpha3 causes lung disease and nephrotic syndrome.
    Authors: Nicolaou N, Margadant C, Kevelam S, Lilien M, Oosterveld M, Kreft M, van Eerde A, Pfundt R, Terhal P, van der Zwaag B, Nikkels P, Sachs N, Goldschmeding R, Knoers N, Renkema K, Sonnenberg A
    J Clin Invest, 2012;122(12):4375-87.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: WB
  6. Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin.
    Authors: Margadant C, Raymond K, Kreft M, Sachs N, Janssen H, Sonnenberg A
    J. Cell. Sci., 2009;122(0):278-88.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: WB

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