Mouse/Rat IGF-I Quantikine ELISA Kit

  (80 citations)
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Product Details
Assay Procedure
Citations (80)
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  • Assay Type
    Solid Phase Sandwich ELISA
  • Format
    96-well strip plate
  • Assay Length
    4.5 hours
  • Sample Type & Volume Required Per Well
    Cell Culture Supernates (25 uL), Tissue Homogenates (50 uL), Serum (10 uL), EDTA Plasma (10 uL), Heparin Plasma (10 uL)
  • Sensitivity
    8.4 pg/mL
  • Assay Range
    31.2 - 2,000 pg/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma)
  • Specificity
    Natural and recombinant mouse and rat IGF-I
  • Cross-reactivity
    < 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
  • Interference
    No significant interference observed with available related molecules.
Product Summary
The Quantikine Mouse/Rat IGF-I Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse and rat IGF-I in cell culture supernates, tissue homogenates, serum, and plasma. It contains E. coli-expressed recombinant mouse IGF-I and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural mouse and rat IGF-I showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring mouse/rat IGF-I.

Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision
Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma
Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 35 35 35
Mean 82 269 921 86 256 863
Standard Deviation 4.6 8.9 37.7 7.8 11.8 37.4
CV% 5.6 3.3 4.1 9.1 4.6 4.3

Recovery

The recovery of mouse/rat IGF-I spiked to three levels throughout the range of the assay in the cell culture supernate samples was evaluated.

Sample Type Average % Recovery Range %
Mouse Cell Culture Supernates (n=7) 98 89-111
Rat Cell Culture Supernates (n=6) 98 82-108
Linearity
To assess the linearity of the assay, samples containing mouse or rat IGF-I in each matrix were diluted with Calibrator Diluent and then assayed.
 IGF-I [HRP]
 IGF-I [HRP]
Product Datasheets

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Preparation and Storage
  • Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: IGF-I

Insulin-like growth factor (IGF)-I (also known as somatomedin C and somatomedin A) and IGF-II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved between the human, bovine and porcine proteins (100% identity), and exhibit cross-species activity.

The IGFL (insulin-like growth factor-like) family includes four small (~11 kDa), probably secreted family members in humans and one in mouse. This family shares A and B chain cysteine motifs with the IGF superfamily, and has an additional cysteine motif within an uncleaved region corresponding to the C peptide of the IGF family.

  • Long Name:
    Insulin-like Growth Factor I
  • Entrez Gene IDs:
    3479 (Human); 16000 (Mouse); 24482 (Rat)
  • Alternate Names:
    IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C
Related Research Areas
Assay Procedure
Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

  3. 50 µL Assay Diluent
  4.   Add 50 µL of Assay Diluent to each well.

  5. 50 µL Standard, Control, or Sample
  6.   Add 50 µL of Standard, Control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours on a horizontal orbital microplate shaker.
  7.   Aspirate each well and wash, repeating the process 4 times for a total of 5 washes.

  8. 100 µL Conjugate
  9.   Add 100 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours on the shaker.
  10.   Aspirate and wash 5 times.

  11. 100 µL Substrate Solution
  12.   Add 100 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes on the benchtop. PROTECT FROM LIGHT.

  13. 100 µL Stop Solution
  14.   Add 100 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

80 Citations: Showing 1 - 10
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Species
Sample Type
  1. Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice
    Authors: J Lu, L Lu, Y Yu, J Cluette-Br, CR Martin, EC Claud
    Sci Rep, 2018;8(1):5443.
    Species: Mouse
    Sample Type: Serum
  2. Transplant of insulin-like growth factor-1 expressing bone marrow stem cells improves functional regeneration of injured rat uterus by NF-?B pathway
    Authors: L Wang, M Yang, M Jin, Y Wu, T Zheng, S Gu, X Hua
    J. Cell. Mol. Med., 2018;0(0):.
    Species: Rat
    Sample Type: Cell Culture Supernates
  3. EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation
    Authors: M Linder, M Hecking, E Glitzner, K Zwerina, M Holcmann, L Bakiri, MG Ruocco, J Tuckermann, G Schett, EF Wagner, M Sibilia
    Cell Death Differ., 2018;0(0):.
    Species: Mouse
    Sample Type: Cell Culture Supernates
  4. The type I insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells
    Authors: MC Fernandez, R Rayes, B Ham, N Wang, F Bourdeau, S Milette, M Lllemann, N Bird, A Majeed, J Xu, T Kisselova, P Brodt
    Oncotarget, 2017;8(32):52281-52293.
    Species: Mouse
    Sample Type: Serum
  5. Mosaic expression of Atrx in the mouse central nervous system causes memory deficits
    Authors: RJ Tamming, JR Siu, Y Jiang, MA Prado, F Beier, NG B?rub?
    Dis Model Mech, 2017;10(2):119-126.
    Species: Mouse
    Sample Type: Plasma
  6. Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice
    Authors: L Luo, C Yan, Y Urata, AS Hasan, S Goto, CY Guo, S Zhang, TS Li
    Sci Rep, 2017;7(0):40959.
    Species: Mouse
    Sample Type: Cell Culture Supernates
  7. Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birth
    Authors: S Becker, H Wang, B Yu, R Brown, X Han, RH Lane, ME Hartnett
    Sci Rep, 2017;7(0):42301.
    Species: Rat
    Sample Type: Serum
  8. Metformin inhibits the proliferation of benign prostatic epithelial cells
    Authors: Z Wang, X Xiao, R Ge, J Li, CW Johnson, C Rassoulian, AF Olumi
    PLoS ONE, 2017;12(3):e0173335.
    Species: Mouse
    Sample Type: Cell Culture Supernates
  9. A novel 5HT3 receptor-IGF1 mechanism distinct from SSRI-induced antidepressant effects
    Authors: M Kondo, Y Koyama, Y Nakamura, S Shimada
    Mol. Psychiatry, 2017;0(0):.
    Species: Mouse
    Sample Type: Serum
  10. Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease
    Authors: M Kugita, K Nishii, T Yamaguchi, A Suzuki, Y Yuzawa, S Horie, E Higashihar, S Nagao
    PLoS ONE, 2017;12(5):e0177934.
    Species: Rat
    Sample Type: Serum
  11. Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction
    Authors: R Cintron-Co, M Sanchez-Al, W Nguyen, S Mori, R Gonzalez-R, T Lien, T Bartfai, S Aïd, JC François, M Holzenberg, B Conti
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
    Species: Mouse
    Sample Type: Serum
  12. Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins
    Authors: KN Charles, MD Li, F Engin, AP Arruda, K Inouye, GS Hotamislig
    Cell Rep, 2017;21(2):393-402.
    Species: Mouse
    Sample Type: Serum
  13. Effects of growth hormone on cardiac remodeling and soleus muscle in rats with aortic stenosis-induced heart failure
    Authors: ARR Lima, LU Pagan, RL Damatto, MDM Cezar, C Bonomo, MJ Gomes, PF Martinez, DM Guizoni, DHS Campos, FC Damatto, K Okoshi, MP Okoshi
    Oncotarget, 2017;8(47):83009-83021.
    Species: Rat
    Sample Type: Serum
  14. Changes of Cerebral and/or Peripheral Adenosine A? Receptor and IGF-I Concentrations under Extended Sleep Duration in Rats
    Authors: M Chennaoui, PJ Arnal, R Dorey, F Sauvet, S Ciret, T Gallopin, D Leger, C Drogou, D Gomez-Meri
    Int J Mol Sci, 2017;18(11):.
    Species: Rat
    Sample Type: Plasma
  15. Topical use and systemic action of green and roasted coffee oils and ground oils in a cutaneous incision model in rats (Rattus norvegicus albinus)
    Authors: BG Lania, J Morari, AL Souza, MND Silva, AR de Almeida, G Veira-Dami, SM Alegre, CL César, LA Velloso, ML Cintra, NB Maia, PENF Velho
    PLoS ONE, 2017;12(12):e0188779.
    Species: Rat
    Sample Type: Serum
  16. IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan
    Authors: NM Ashpole, S Logan, A Yabluchans, MC Mitschelen, H Yan, JA Farley, EL Hodges, Z Ungvari, A Csiszar, S Chen, C Georgescu, GB Hubbard, Y Ikeno, WE Sonntag
    Geroscience, 2017;0(0):.
    Species: Mouse
    Sample Type: Serum
  17. Single ingestion of soy ?-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects
    Authors: Tsutomu Hashidume
    Sci Rep, 2016;6(0):28183.
    Species: Mouse
    Sample Type: Serum
  18. Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery
    Authors: Li Zhou
    Biomaterials, 2016;117(0):24-31.
    Species: Mouse
    Sample Type: Plasma
  19. Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome
    Authors: Lisa C Burnett
    J. Clin. Invest, 2016;0(0):.
    Species: Mouse
    Sample Type: Plasma
  20. Positive Prehabilitative Effect of Intense Treadmill Exercise for Ameliorating Cancer Cachexia Symptoms in a Mouse Model
    J Cancer, 2016;7(15):2378-2387.
    Species: Mouse
    Sample Type: Plasma
  21. The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats
    J Neuroinflammation, 2016;13(1):300.
    Species: Rat
    Sample Type: Serum
  22. Fibroblast growth factor 21 has no direct role in regulating fertility in female mice
    Mol Metab, 2016;5(8):690-8.
    Species: Mouse
    Sample Type: Plasma
  23. First steps to define murine amniotic fluid stem cell microenvironment
    Sci Rep, 2016;6(0):37080.
    Species: Mouse
    Sample Type: Amniotic Fluid
  24. Radiation Exposure Decreases the Quantity and Quality of Cardiac Stem Cells in Mice
    PLoS ONE, 2016;11(5):e0152179.
    Species: Mouse
    Sample Type: Cell Culture Supernates
  25. Cluster Differentiating 36 (CD36) Deficiency Attenuates Obesity-Associated Oxidative Stress in the Heart
    PLoS ONE, 2016;11(5):e0155611.
    Species: Mouse
    Sample Type: Plasma
  26. IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction
    Authors: Thor Tejada
    Proc Natl Acad Sci USA, 2016;0(0):.
    Species: Mouse
    Sample Type: Serum
  27. Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine
    Sci Rep, 2016;6(0):31853.
    Species: Mouse
    Sample Type: Serum
  28. MeCP2 Affects Skeletal Muscle Growth and Morphology through Non Cell-Autonomous Mechanisms.
    Authors: Conti V, Gandaglia A, Galli F, Tirone M, Bellini E, Campana L, Kilstrup-Nielsen C, Rovere-Querini P, Brunelli S, Landsberger N
    PLoS ONE, 2015;10(6):e0130183.
    Species: Mouse
    Sample Type: Plasma
  29. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
    Authors: Baker D, Childs B, Durik M, Wijers M, Sieben C, Zhong J, Saltness R, Jeganathan K, Verzosa G, Pezeshki A, Khazaie K, Miller J, van Deursen J
    Nature, 2015;530(7589):184-9.
    Species: Mouse
    Sample Type: Serum
  30. Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice.
    Authors: Charolidi N, Schilling T, Eder C
    PLoS ONE, 2015;10(5):e0128463.
    Species: Mouse
    Sample Type: Cell Culture Supernates
  31. Glucose intolerance in aging male IGFBP-3 transgenic mice: differential effects of human IGFBP-3 and its mutant IGFBP-3 devoid of IGF binding ability.
    Authors: Nguyen K, Yao X, Erickson A, Mishra S, Nyomba B
    Endocrinology, 2015;156(2):462-74.
    Species: Mouse
    Sample Type: Serum
  32. The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate suppresses chemically induced lung alveolar proliferative lesions in male obese hyperlipidemic mice.
    Authors: Kuno T, Hata K, Takamatsu M, Hara A, Hirose Y, Takahashi S, Imaida K, Tanaka T
    Int J Mol Sci, 2014;15(5):9160-72.
    Species: Mouse
    Sample Type: Plasma
  33. The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone.
    Authors: Nuytens, Kim, Tuand, Krizia, Fu, Quili, Stijnen, Pieter, Pruniau, Vincent, Meulemans, Sandra, Vankelecom, Hugo, Creemers, John W M
    PLoS ONE, 2014;9(10):e109598.
    Species: Mouse
    Sample Type: Plasma
  34. HGF signaling impacts severity of Pseudomonas aeruginosa keratitis.
    Authors: Jiang X, McClellan S, Barrett R, Foldenauer M, Hazlett L
    Invest Ophthalmol Vis Sci, 2014;55(4):2180-90.
    Species: Mouse
    Sample Type: Tissue Homogenates
  35. Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver.
    Authors: Fernandez-Perez L, Santana-Farre R, de Mirecki-Garrido M, Garcia I, Guerra B, Mateo-Diaz C, Iglesias-Gato D, Diaz-Chico J, Flores-Morales A, Diaz M
    PLoS ONE, 2014;9(5):e96305.
    Species: Rat
    Sample Type: Serum
  36. Viral expression of insulin-like growth factor I E-peptides increases skeletal muscle mass but at the expense of strength.
    Authors: Brisson, Becky K, Spinazzola, Janelle, Park, SooHyun, Barton, Elisabet
    Am J Physiol Endocrinol Metab, 2014;306(8):E965-74.
    Species: Mouse
    Sample Type: Tissue Homogenates
  37. The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.
    Authors: Sapra, Geeta, Tham, Yow Keat, Cemerlang, Nelly, Matsumoto, Aya, Kiriazis, Helen, Bernardo, Bianca C, Henstridge, Darren C, Ooi, Jenny Y, Pretorius, Lynette, Boey, Esther J, Lim, Lydia, Sadoshima, Junichi, Meikle, Peter J, Mellet, Natalie, Woodcock, Elizabet, Marasco, Silvana, Ueyama, Tomomi, Du, Xiao-Jun, Febbraio, Mark A, McMullen, Julie R
    Nat Commun, 2014;5(0):5705.
    Species: Mouse
    Sample Type: Plasma
  38. IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice.
    Authors: Mellott T, Pender S, Burke R, Langley E, Blusztajn J
    PLoS ONE, 2014;9(4):e94287.
    Species: Mouse
    Sample Type: Tissue Homogenates
  39. Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.
    Authors: Gealekman O, Gurav K, Chouinard M, Straubhaar J, Thompson M, Malkani S, Hartigan C, Corvera S
    J Biol Chem, 2014;289(26):18327-38.
    Species: Mouse
    Sample Type: Tissue Homogenates
  40. Time-dependent expression profiles of microRNAs and mRNAs in rat milk whey.
    Authors: Izumi, Hirohisa, Kosaka, Nobuyosh, Shimizu, Takashi, Sekine, Kazunori, Ochiya, Takahiro, Takase, Mitsunor
    PLoS ONE, 2014;9(2):e88843.
    Species: Rat
    Sample Type: Serum
  41. sigma1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue.
    Authors: Baltes J, Larsen J, Radhakrishnan K, Geumann C, Kratzke M, Petersen C, Schu P
    J Cell Sci, 2014;127(0):3477-87.
    Species: Mouse
    Sample Type: Serum
  42. Administration of saccharin to neonatal mice influences body composition of adult males and reduces body weight of females.
    Authors: Parlee, Sebastia, Simon, Becky R, Scheller, Erica L, Alejandro, Emilyn U, Learman, Brian S, Krishnan, Venkates, Bernal-Mizrachi, Ernesto, MacDougald, Ormond A
    Endocrinology, 2014;155(4):1313-26.
    Species: Mouse
    Sample Type: Serum
  43. Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast.
    Authors: Hirose J, Masuda H, Tokuyama N, Omata Y, Matsumoto T, Yasui T, Kadono Y, Hennighausen L, Tanaka S
    J Exp Med, 2014;211(1):153-63.
    Species: Mouse
    Sample Type: Serum
  44. The order of concurrent endurance and resistance exercise modifies mTOR signaling and protein synthesis in rat skeletal muscle.
    Authors: Ogasawara R, Sato K, Matsutani K, Nakazato K, Fujita S
    Am J Physiol Endocrinol Metab, 2014;306(10):E1155-62.
    Species: Rat
    Sample Type: Serum
  45. Overlapping dose responses of spermatogenic and extragonadal testosterone actions jeopardize the principle of hormonal male contraception.
    Authors: Oduwole O, Vydra N, Wood N, Samanta L, Owen L, Keevil B, Donaldson M, Naresh K, Huhtaniemi I
    FASEB J, 2014;28(6):2566-76.
    Species: Mouse
    Sample Type: Serum
  46. Sonic hedgehog gene therapy increases the ability of the dystrophic skeletal muscle to regenerate after injury.
    Authors: Piccioni A, Gaetani E, Palladino M, Gatto I, Smith R, Neri V, Marcantoni M, Giarretta I, Silver M, Straino S, Capogrossi M, Landolfi R, Pola R
    Gene Ther, 2014;21(4):413-21.
    Species: Mouse
    Sample Type: Cell Culture Supernates
  47. Long-term physiological alterations and recovery in a mouse model of separation associated with time-restricted feeding: a tool to study anorexia nervosa related consequences.
    Authors: Zgheib S, Mequinion M, Lucas S, Leterme D, Ghali O, Tolle V, Zizzari P, Bellefontaine N, Legroux-Gerot I, Hardouin P, Broux O, Viltart O, Chauveau C
    PLoS ONE, 2014;9(8):e103775.
    Species: Mouse
    Sample Type: Plasma
  48. Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-kappaB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner.
    Authors: Harvey A, Lashinger L, Hays D, Harrison L, Lewis K, Fischer S, Hursting S
    PLoS ONE, 2014;9(5):e94151.
    Species: Mouse
    Sample Type: Serum
  49. Survival of neural stem cell grafts in the lesioned spinal cord is enhanced by a combination of treadmill locomotor training via insulin-like growth factor-1 signaling.
    Authors: Hwang D, Shin H, Kwon M, Choi J, Ryu B, Kim B
    J Neurosci, 2014;34(38):12788-800.
    Species: Rat
    Sample Type: Serum
  50. Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine.
    Authors: Keipert S, Ost M, Johann K, Imber F, Jastroch M, van Schothorst E, Keijer J, Klaus S
    Am J Physiol Endocrinol Metab, 2014;306(5):E469-82.
    Species: Mouse
    Sample Type: Plasma
  51. Growth hormone secretion is correlated with neuromuscular innervation rather than motor neuron number in early-symptomatic male amyotrophic lateral sclerosis mice.
    Authors: Steyn, F J, Lee, K, Fogarty, M J, Veldhuis, J D, McCombe, P A, Bellingham, M C, Ngo, S T, Chen, C
    Endocrinology, 2013;154(12):4695-706.
    Species: Mouse
    Sample Type: Plasma
  52. SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver.
    Authors: Yamamoto, Masaaki, Iguchi, Genzo, Fukuoka, Hidenori, Suda, Kentaro, Bando, Hironori, Takahashi, Michiko, Nishizawa, Hitoshi, Seino, Susumu, Takahashi, Yutaka
    Proc Natl Acad Sci U S A, 2013;110(37):14948-53.
    Species: Mouse
    Sample Type: Serum
  53. BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease.
    Authors: Burke R, Norman T, Haydar T, Slack B, Leeman S, Blusztajn J, Mellott T
    Proc Natl Acad Sci U S A, 2013;110(48):19567-72.
    Species: Mouse
    Sample Type: Tissue Homogenates
  54. Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function.
    Authors: Sen S, Jumaa H, Webster N
    Nat Commun, 2013;4(0):1336.
    Species: Mouse
    Sample Type: Serum
  55. Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways.
    Authors: Al-Qusairi L, Prokic I, Amoasii L, Kretz C, Messaddeq N, Mandel J, Laporte J
    FASEB J, 2013;27(8):3384-94.
    Species: Mouse
    Sample Type: Plasma
  56. IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter.
    Authors: Ock, Sangmi, Ahn, Jihyun, Lee, Seok Hon, Kang, Hyun, Offermanns, Stefan, Ahn, Hwa Youn, Jo, Young Su, Shong, Minho, Cho, Bo Youn, Jo, Daewoong, Abel, E Dale, Lee, Tae Jin, Park, Woo Jin, Lee, In-Kyu, Kim, Jaetaek
    FASEB J, 2013;27(12):4899-908.
    Species: Mouse
    Sample Type: Serum
  57. IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells.
    Authors: Osuka S, Sampetrean O, Shimizu T, Saga I, Onishi N, Sugihara E, Okubo J, Fujita S, Takano S, Matsumura A, Saya H
    Stem Cells, 2013;31(4):627-40.
    Species: Mouse
    Sample Type: Cell Lysates
  58. Effects of breastfeeding on body composition and maturational tempo in the rat.
    Authors: Crispel, Yonatan, Katz, Oren, Ben-Yosef, Dafna, Hochberg, Ze'ev
    BMC Med, 2013;11(0):114.
    Species: Rat
    Sample Type: Serum
  59. The restorative effects of adipose-derived mesenchymal stem cells on damaged ovarian function.
    Authors: Takehara, Yuji, Yabuuchi, Akiko, Ezoe, Kenji, Kuroda, Tomoko, Yamadera, Rie, Sano, Chiaki, Murata, Nana, Aida, Takuya, Nakama, Ken, Aono, Fumihito, Aoyama, Naoki, Kato, Keiich, Kato, Osamu
    Lab Invest, 2013;93(2):181-93.
    Species: Rat
    Sample Type: Cell Culture Supernates
  60. Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression.
    Authors: Lloyd J, Masko E, Wu C, Keenan M, Pilla D, Aronson W, Chi J, Freedland S
    Prostate Cancer Prostatic Dis, 2013;16(4):285-91.
    Species: Mouse
    Sample Type: Serum
  61. Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway.
    Authors: Ma B, Zhang Q, Wu D, Wang YL, Hu YY, Cheng YP, Yang ZD, Zheng YY, Ying HJ
    Acta Pharmacol. Sin., 2012;33(4):479-89.
    Species: Rat
    Sample Type: Serum
  62. Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice.
    Authors: Al-Dwairi, Ahmed, Pabona, John Mar, Simmen, Rosalia, Simmen, Frank A
    PLoS ONE, 2012;7(10):e46716.
    Species: Mouse
    Sample Type: Serum
  63. Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
    Authors: Sato H, Isogai Y, Masuda S
    J. Biol. Chem., 2011;286(13):11632-48.
    Species: Mouse
    Sample Type: Serum
  64. Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model.
    Authors: Hua Y, Sahashi K, Rigo F
    Nature, 2011;478(7367):123-6.
    Species: Mouse
    Sample Type: Serum
  65. Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.
    Authors: Maurer GD, Brucker DP, Bahr O, Harter PN, Hattingen E, Walenta S, Mueller-Klieser W, Steinbach JP, Rieger J
    BMC Cancer, 2011;11(0):315.
    Species: Mouse
    Sample Type: Serum
  66. Human IGF Binding Protein-3 Overexpression Impairs Glucose Regulation in Mice via an Inhibition of Insulin Secretion.
    Authors: Nguyen KH, Yao XH, Moulik S, Mishra S, Nyomba BL
    Endocrinology, 2011;152(6):2184-96.
    Species: Mouse
    Sample Type: Plasma
  67. Galectin-3 contributes to neonatal hypoxic-ischemic brain injury.
    Authors: Doverhag C, Hedtjarn M, Poirier F, Mallard C, Hagberg H, Karlsson A, Savman K
    Neurobiol. Dis., 2010;38(1):36-46.
    Species: Mouse
    Sample Type: Tissue Homogenates
  68. Myocytic androgen receptor controls the strength but not the mass of limb muscles.
    Authors: Chambon C, Duteil D, Vignaud A, Ferry A, Messaddeq N, Malivindi R, Kato S, Chambon P, Metzger D
    Proc. Natl. Acad. Sci. U.S.A., 2010;107(32):14327-32.
    Species: Mouse
    Sample Type: Plasma
  69. Rim2alpha determines docking and priming States in insulin granule exocytosis.
    Authors: Yasuda T, Shibasaki T, Minami K
    Cell Metab., 2010;12(2):117-29.
    Species: Mouse
    Sample Type: Serum
  70. Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9.
    Authors: Koronyo-Hamaoui M, Ko MK, Koronyo Y, Azoulay D, Seksenyan A, Kunis G, Pham M, Bakhsheshian J, Rogeri P, Black KL, Farkas DL, Schwartz M
    J. Neurochem., 2009;111(6):1409-24.
    Species: Mouse
    Sample Type: Tissue Homogenates
  71. Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance.
    Authors: Ashare A, Nymon AB, Doerschug KC, Morrison JM, Monick MM, Hunninghake GW
    Am. J. Respir. Crit. Care Med., 2008;178(2):149-57.
    Species: Mouse
    Sample Type: Serum
  72. Reduction in hypophyseal growth hormone and prolactin expression due to deficiency in ghrelin receptor signaling is associated with Pit-1 suppression: Relevance to the immune system.
    Authors: Yang H, Dixit VD, Patel K, Vandanmagsar B, Collins G, Sun Y, Smith RG, Taub DD
    Brain Behav. Immun., 2008;0(0):.
    Species: Mouse
    Sample Type: Serum
  73. Low-dose GH supplementation reduces the TLR2 and TNF-alpha expressions in visceral fat.
    Authors: Kubota Y, Unoki H, Bujo H, Rikihisa N, Udagawa A, Yoshimoto S, Ichinose M, Saito Y
    Biochem. Biophys. Res. Commun., 2008;368(1):81-7.
    Species: Mouse
    Sample Type: Plasma
  74. Modulation of melanocortin signaling ameliorates uremic cachexia.
    Authors: Cheung WW, Rosengren S, Boyle DL, Mak RH
    Kidney Int., 2008;74(2):180-6.
    Species: Mouse
    Sample Type: Tissue Homogenates
  75. Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
    Authors: Paintlia AS, Paintlia MK, Singh AK, Singh I
    Mol. Pharmacol., 2008;73(5):1381-93.
    Species: Rat
    Sample Type: Serum
  76. Microcytosis in ank/ank mice and the role of ANKH in promoting erythroid differentiation.
    Authors: Wang J, Wang C, Tsui HW, Las Heras F, Cheng EY, Iscove NN, Chiu B, Inman RD, Pritzker KP, Tsui FW
    Exp. Cell Res., 2007;313(20):4120-9.
    Species: Mouse
    Sample Type: Serum
  77. Ghrelin promotes thymopoiesis during aging.
    Authors: Dixit VD, Yang H, Sun Y, Weeraratna AT, Youm YH, Smith RG, Taub DD
    J. Clin. Invest., 2007;117(10):2778-90.
    Species: Mouse
    Sample Type: Serum
  78. Wheel running and fluoxetine antidepressant treatment have differential effects in the hippocampus and the spinal cord.
    Authors: Engesser-Cesar C, Anderson AJ, Cotman CW
    Neuroscience, 2007;144(3):1033-44.
    Species: Mouse
    Sample Type: Serum
  79. Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models.
    Authors: Lanz TA, Salatto CT, Semproni AR, Marconi M, Brown TM, Richter KE, Schmidt K, Nelson FR, Schachter JB
    Biochem. Pharmacol., 2007;75(5):1093-103.
    Species: Rat
    Sample Type: Plasma
  80. Ovariectomy is protective against renal injury in the high-salt-fed older mRen2.Lewis rat.
    Authors: Yamaleyeva LM, Pendergrass KD, Pirro NT, Gallagher PE, Groban L, Chappell MC
    Am. J. Physiol. Heart Circ. Physiol., 2007;293(4):H2064-71.
    Species: Rat
    Sample Type: Plasma
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