Mouse TSLP Antibody
Mouse TSLP Antibody Summary
Tyr20-Glu140
Accession # Q9JIE6
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Cell Proliferation Induced by TSLP and Neutralization by Mouse TSLP Antibody. Recombinant Mouse TSLP (Catalog # 555-TS) stimulates proliferation in the BaF3 mouse pro‑B cell line transfected with mouse IL‑7 Ra in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse TSLP (7.5 ng/mL) is neutralized (green line) by increasing concentrations of Mouse TSLP Monoclonal Antibody (Catalog # MAB555). The ND50 is typically 0.1-0.4 µg/mL.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TSLP
TSLP is an IL-7 related cytokine secreted by multiple tissues. It interacts with the heterodimeric receptor complex consisting of IL-7 R alpha and TSLP R. Mouse TSLP stimulates the growth of thymocytes and mature T cells and also supports B cell lymphopoiesis.
Product Datasheets
Citations for Mouse TSLP Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment
Authors: W Yao, B German, D Chraa, A Braud, C Hugel, P Meyer, G Davidson, P Laurette, G Mengus, E Flatter, P Marschall, J Segaud, M Guivarch, P Hener, MC Birling, D Lipsker, I Davidson, M Li
JCI Insight, 2022;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease
Authors: Z Shen, W Luo, B Tan, K Nie, M Deng, S Wu, M Xiao, X Wu, X Meng, T Tong, C Zhang, K Ma, Y Liao, J Xu, X Wang
EBioMedicine, 2022;85(0):104285.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Eosinophil extracellular traps drive asthma progression through neuro-immune signals
Authors: Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li, Q Xia, Q Zhao, L Huang, S Jiang, S Su
Nature Cell Biology, 2021;23(10):1060-1072.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure
Authors: N Majumder, WT Goldsmith, VK Kodali, M Velayutham, SA Friend, VV Khramtsov, TR Nurkiewicz, A Erdely, PC Zeidler-Er, V Castranova, JR Harkema, EE Kelley, S Hussain
Redox Biology, 2021;46(0):102092.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway
Authors: S Li, Z Yi, M Deng, MJ Scott, C Yang, W Li, Z Lei, NM Santerre, P Loughran, TR Billiar
JCI Insight, 2019;4(22):.
Species: Mouse
Sample Types: Cell Lysates
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TSLP Exacerbates Septic Inflammation via Murine Double Minute 2 (MDM2) Signaling Pathway
Authors: NR Han, PD Moon, HM Kim, HJ Jeong
J Clin Med, 2019;8(9):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralizing -
Frontline Science: Nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway dendritic cells and subsequent IgA response
Authors: Y Cao, E Zhang, J Yang, Y Yang, J Yu, Y Xiao, W Li, D Zhou, Y Li, B Zhao, H Yan, M Lu, M Zhong, H Yan
J. Leukoc. Biol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response
Mucosal Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Thymic Stromal Lymphopoietin Neutralization Inhibits the Immune Adjuvant Effect of Di-(2-Ethylhexyl) Phthalate in Balb/c Mouse Asthma Model
PLoS ONE, 2016;11(7):e0159479.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin Disease.
Authors: Yu M, Owens D, Ghosh S, Farber D
J Invest Dermatol, 2015;135(11):2688-96.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1alpha/IL-6 loop.
Authors: Taniguchi K, Arima K, Masuoka M, Ohta S, Shiraishi H, Ontsuka K, Suzuki S, Inamitsu M, Yamamoto K, Simmons O, Toda S, Conway S, Hamasaki Y, Izuhara K
J Invest Dermatol, 2014;134(5):1295-304.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility.
Authors: Cipolat S, Hoste E, Natsuga K, Quist S, Watt F
Elife, 2014;3(0):e01888.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Peroxisome proliferator-activated receptor gamma-mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC/Tnd mice.
Authors: Jung K, Tanaka A, Fujita H, Matsuda A, Oida K, Karasawa K, Okamoto N, Ohmori K, Jee Y, Shin T, Matsuda H
J. Allergy Clin. Immunol., 2011;127(2):420-29.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin.
Authors: Oh MH, Oh SY, Yu J
J. Immunol., 2011;186(12):7232-42.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Thymic stromal lymphopoietin is a key mediator of breast cancer progression.
Authors: Olkhanud PB, Rochman Y, Bodogai M
J. Immunol., 2011;186(10):5656-62.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation.
Authors: Boehme SA, Franz-Bacon K, Chen EP, Sasik R, Sprague LJ, Ly TW, Hardiman G, Bacon KB
Int. Immunol., 2009;21(1):81-93.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation.
Authors: Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, Okumura K, Ogawa H, Masuyama K, Nakao A
Eur. J. Immunol., 2009;39(11):3078-83.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
A mechanism for the initiation of allergen-induced T helper type 2 responses.
Authors: Sokol CL, Barton GM, Farr AG, Medzhitov R
Nat. Immunol., 2008;9(3):310-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
Authors: Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG
Blood, 2007;109(9):3706-12.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9<sup>+</sup> and IL-13<sup>+</sup> type 2 innate lymphoid cell subpopulations.
Authors: Verma M, Liu S, Michalec L, Sripada A, Gorska M, Alam R
J Allergy Clin Immunol, 0;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization
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Reviews for Mouse TSLP Antibody
Average Rating: 3.5 (Based on 2 Reviews)
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***Bio-Techne Response: Thank you for reviewing our product. We are sorry to that that this antibody did not perform as expected. We have been in touch with the customer to resolve this issue according to our Product Guarantee and to the customer’s satisfaction.***
Although MAB555 has not been validated by Bio-Techne for IHC/ICC/IF application, Technical Service provided troubleshooting suggestions, which resulted in a weak signal in tissues tested. Customer observed a good signal with polyclonal antibody from Novus, catalog # NB110-55234.
