Phospho-GSK-3 alpha/beta (S21/S9) Cell-Based ELISA

Name: Phospho-GSK-3 alpha/beta (S21/S9) Cell-Based ELISA
Brand: R&D Systems
SKU: KCB1590

Catalog #: KCB1590 Datasheet / COA / SDS

Discontinued Product

KCB1590 has been discontinued.

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All GSK-3 alpha/beta ELISAs

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Summary Product Datasheets Preparation and Storage Background

Phospho-GSK-3 alpha/beta (S21/S9) Cell-Based ELISA Summary

Alternatively

* Alternatively, this assay can be run over two days, which requires 2 hours 30 mins (day 1) and 4 hours (day 2).

* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.

Product Datasheets

Product Datasheet

COA

SDS

Preparation and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: GSK-3 alpha/beta

GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.

Long Name:

Glycogen Synthase Kinase 3

Alternate Names:

DKFZp686D0638; EC 2.7.11; EC 2.7.11.26; glycogen synthase kinase 3 alpha; glycogen synthase kinase-3 alpha; GSK-3 alpha; GSK-3 alpha/beta