Proteome Profiler Human XL Cytokine Array Kit
Proteome Profiler Human XL Cytokine Array Kit Summary
Proteome Profiler™ Human XL Cytokine Array Kit
Principle of the Array
The Proteome Profiler Human XL Cytokine Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Captured proteins are detected with biotinylated detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of analyte bound.
Why Use an Antibody Array to Detect Multiple Cytokines?
Determining the expression of multiple cytokines in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple cytokines in a single sample can be cost-effective and also save time and sample.
Kit Contents
- Rectangular 4-Well Multi-dish
- 4 Human XL Cytokine Array nitrocellulose membranes spotted with 102 different antibodies to human cytokines
- Array Buffer 4
- Array Buffer 6
- Chemi Reagent 1
- Chemi Reagent 2
- Detection Antibody Cocktail, Human XL Cytokine Array
- Streptavidin-HRP
- Transparency Overlay Template
- Wash Buffer Concentrate (25X)
For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.
Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample. | ||
Adiponectin/Acrp30 | IFN-gamma | Lipocalin-2/NGAL |
Aggrecan | IGFBP-2 | CCL2/MCP-1 |
Angiogenin | IGFBP-3 | CCL7/MCP-3 |
Angiopoietin-1 | IL-1 alpha/IL-1F1 | M-CSF |
Angiopoietin-2 | IL-1 beta/IL-1F2 | MIF |
BAFF/BLyS/TNFSF13B | IL-1ra/IL-1F3 | CXCL9/MIG |
BDNF | IL-2 | CCL3/CCL4 MIP-1 alpha/beta |
CD14 | IL-3 | CCL20/MIP-3 alpha |
CD30 | IL-4 | CCL19/MIP-3 beta |
CD40 Ligand/TNFSF5 | IL-5 | MMP-9 |
Chitinase 3-like | IL-6 | Myeloperoxidase |
Complement Component C5/C5a | IL-8 | Osteopontin (OPN) |
Complement Factor D | IL-10 | PDGF-AA |
C-Reactive Protein/CRP | IL-11 | PDGF-AB/BB |
Cripto-1 | IL-12 p70 | Pentraxin 3/TSF-14 |
Cystatin C | IL-13 | CXCL4/PF4 |
Dkk-1 | IL-15 | RAGE |
DPPIV/CD26 | IL-16 | CCL5/RANTES |
EGF | IL-17A | RBP4 |
CXCL5/ENA-78 | IL-18 BPa | Relaxin-2 |
Endoglin/CD105 | IL-19 | Resistin |
EMMPRIN | IL-22 | CXCL12/SDF-1 alpha |
Fas Ligand | IL-23 | Serpin E1/PAI-1 |
FGF basic | IL-24 | SHBG |
KGF/FGF-7 | IL-27 | ST2/IL1 R4 |
FGF-19 | IL-31 | CCL17/TARC |
Flt-3 Ligand | IL-32 alpha/beta/gamma | TFF3 |
G-CSF | IL-33 | TfR |
GDF-15 | IL-34 | TGF-alpha |
GM-CSF | CXCL10/IP-10 | Thrombospondin-1 |
CXCL1/GRO alpha | CXCL11/I-TAC | TNF-alpha |
Growth Hormone (GH) | Kallikrein 3/PSA | uPAR |
HGF | Leptin | VEGF |
ICAM-1/CD54 | LIF | Vitamin D BP |
Stability and Storage
Store the unopened kit at 2°C to 8°C. Do not use past kit expiration date.
Data Examples
The Human XL Cytokine Array detects multiple cytokines, chemokines, growth factors and other soluble proteins in cell culture supernates. Cells were untreated or treated as indicated below. 500 µL of cell culture supernate was run on each array. Data shown are from a 10 minute exposure to X-ray film. Profiles of mean spot pixel density were created using a transmission-mode scanner and image analysis software.
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Figure 1A. HUVEC human umbilical vein endothelial cells were untreated or treated with 100 µg/mL recombinant human TNF-alpha (Catalog #210-TA) for 24 hours. |
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Figure 1B. SW480 human colorectal adenocarcinoma cells were untreated or treated with 100 ng/mL of LPS for 24 hours. |
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Figure 1C. THP-1 human acute monocytic leukemia cells untreated or treated with 1 µg/mL of recombinant human IFN-gamma (Catalog #285-IF) for 16 hours and 1 µ/mL of LPS for 8 hours. |
Specifications
Product Datasheets
Complete Your Research
Citations for Proteome Profiler Human XL Cytokine Array Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients
Authors: L Saber Cher, Z Diabasana, JM Perotin, J Ancel, LMG Petit, MA Devilliers, A Bonnomet, N Lalun, G Delepine, U Maskos, P Gosset, M Polette, A Muggeo, T Guillard, G Deslée, V Dormoy
Cells, 2022;11(19):. 2022
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Serum biomarkers of neuroinflammation and blood-brain barrier leakage in amyotrophic lateral sclerosis
Authors: MC Cao, EE Cawston, G Chen, C Brooks, J Douwes, D McLean, ES Graham, M Dragunow, EL Scotter
BMC neurology, 2022;22(1):216. 2022
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Isolation of Platelet-Derived Exosomes from Human Platelet-Rich Plasma: Biochemical and Morphological Characterization
Authors: M Saumell-Es, D Delgado, G García Del, M Beitia, J Sallés, I González-B, P Sánchez, M López de J, S Barrondo, M Sánchez
International Journal of Molecular Sciences, 2022;23(5):. 2022
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Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair
Authors: X Zhang, S Zheng, C Hu, G Li, H Lin, R Xia, Y Ye, R He, Z Li, Q Lin, R Chen, Q Zhou
Oncogene, 2022;0(0):. 2022
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Ibuprofen in Therapeutic Concentrations Affects the Secretion of Human Bone Marrow Mesenchymal Stromal Cells, but Not Their Proliferative and Migratory Capacity
Authors: A Kulesza, K Zielniok, J Hawryluk, L Paczek, A Burdzinska
Biomolecules, 2022;12(2):. 2022
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Comprehensive Molecular Landscape of Cetuximab Resistance in Head and Neck Cancer Cell Lines
Authors: INF Gomes, RJ da Silva-O, LS da Silva, O Martinho, AF Evangelist, A van Helvoo, LF Leal, VAO Silva, SP Dos Santos, FC Nascimento, A Lopes Carv, RM Reis
Cells, 2022;11(1):. 2022
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Chemerin Overexpression in the Liver Protects against Inflammation in Experimental Non-Alcoholic Steatohepatitis
Authors: R Pohl, S Feder, EM Haberl, L Rein-Fisch, TS Weiss, M Spirk, A Bruckmann, N McMullen, CJ Sinal, C Buechler
Biomedicines, 2022;10(1):. 2022
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ERalpha36-High Cancer-Associated Fibroblasts as an Unfavorable Factor in Triple-Negative Breast Cancer
Authors: A Nagel, M Popeda, A Muchlinska, R Sadej, J Szade, J Zielinski, J Skokowski, M Niemira, A Kretowski, A Markiewicz, AJ Zaczek
Cancers, 2022;14(8):. 2022
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Analysis of gingival crevicular fluid biomarkers in patients with metabolic syndrome
Authors: L Nibali, A Stephen, E Hagi-Pavli, R Allaker, AD Pino, V Terranova, M Pisano, SD Marca, V Ferrara, R Scicali, M Giordano, F Purrello, N Donos, L Malatino
Journal of dentistry, 2022;118(0):104065. 2022
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Na�ve Human Macrophages Are Refractory to SARS-CoV-2 Infection and Exhibit a Modest Inflammatory Response Early in Infection
Authors: Z Zhang, R Penn, WS Barclay, ES Giotis
Viruses, 2022;14(2):. 2022
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LCN2 is a new diagnostic biomarker and potential therapeutic target in idiopathic short stature
Authors: X Liu, J Zhang, J Yuan, R Ding, T Liu, J Jia
Journal of Cellular and Molecular Medicine, 2022;0(0):. 2022
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Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer
Authors: M Kakarla, S ChallaSiva, MF Dufficy, V Gil, Y Filipovich, R Vickman, SE Crawford, SW Hayward, OE Franco
Cancers, 2022;14(9):. 2022
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IFN-gamma and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma
Authors: L Homann, M Rentschler, E Brenner, K Böhm, M Röcken, T Wieder
Cells, 2022;11(9):. 2022
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Cell-Type Dependent Regulation of the Electrogenic Na+/HCO3- Cotransporter 1 (NBCe1) by Hypoxia and Acidosis in Glioblastoma
Authors: M Giannaki, DE Ruf, E Pfeifer, K Everaerts, DH Heiland, O Schnell, CR Rose, E Roussa
International Journal of Molecular Sciences, 2022;23(16):. 2022
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Human Osteochondral Explants as an Ex Vivo Model of Osteoarthritis for the Assessment of a Novel Class of Orthobiologics
Authors: C Giannasi, L Mangiavini, S Niada, A Colombo, E Della Mort, V Vismara, A Ambrosanio, P Savadori, S Casati, GM Peretti, AT Brini
Pharmaceutics, 2022;14(6):. 2022
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Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions
Authors: L Brandolini, M d'Angelo, R Novelli, V Castelli, C Giorgio, A Sirico, P Cocchiaro, F D'Egidio, E Benedetti, C Cristiano, A Bugatti, A Ruocco, PG Amendola, C Talarico, C Manelfi, D Iaconis, A Beccari, AU Quadros, TM Cunha, A Caruso, R Russo, A Cimini, A Aramini, M Allegretti
Cell Death & Disease, 2022;13(5):500. 2022
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Preferential stimulation of melanocytes by M2 macrophages to produce melanin through vascular endothelial growth factor
Authors: H Han, Y Kim, H Mo, SH Choi, K Lee, YA Rim, JH Ju
Scientific Reports, 2022;12(1):6416. 2022
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During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes
Authors: E Pylaeva, G Korschunow, I Spyra, S Bordbari, E Siakaeva, I Ozel, M Domnich, A Squire, A Hasenberg, K Thangavelu, T Hussain, M Goetz, KS Lang, M Gunzer, W Hansen, J Buer, A Bankfalvi, S Lang, J Jablonska
Cell Reports, 2022;40(7):111171. 2022
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Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells
Authors: N Igarashi, K Miyata, TM Loo, M Chiba, A Hanyu, M Nishio, H Kawasaki, H Zheng, S Toyokuni, S Kon, K Moriyama, Y Fujita, A Takahashi
Oncogene, 2022;13(1):4157. 2022
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Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
Authors: BF Vahsen, E Gray, A Candalija, KML Cramb, J Scaber, R Dafinca, A Katsikoudi, Y Xu, L Farrimond, R Wade-Marti, WS James, MR Turner, SA Cowley, K Talbot
Scientific Reports, 2022;12(1):12606. 2022
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The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells
Authors: D Ávila-Gonz, W Portillo, CP Barragán-Á, G Hernandez-, E Flores-Gar, A Molina-Her, NE Díaz-Martí, NF Díaz
Elife, 2022;11(0):. 2022
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Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1
Authors: H Stölting, L Baillon, R Frise, K Bonner, RJ Hewitt, PL Molyneaux, ML Gore, Breathing, WS Barclay, S Saglani, CM Lloyd
Mucosal Immunology, 2022;0(0):. 2022
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Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance
Authors: R Islam, J Mishra, NS Polavaram, S Bhattachar, Z Hong, S Bodas, S Sharma, A Bouska, T Gilbreath, AM Said, LM Smith, BA Teply, MH Muders, SK Batra, K Datta, S Dutta
Oncogene, 2022;40(3):111097. 2022
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Targeting HIC1/TGF-beta axis-shaped prostate cancer microenvironment restrains its progression
Authors: T Wu, W Wang, G Shi, M Hao, Y Wang, M Yao, Y Huang, L Du, X Zhang, D Ye, X Bian, J Wang
Cell Death & Disease, 2022;13(7):624. 2022
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The kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer
Authors: C Ji, M Zhang, J Hu, C Cao, Q Gu, Y Liu, X Li, D Xu, L Ying, Y Yang, H Gao, J Li, L Yu
Cell Death & Disease, 2022;13(7):577. 2022
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The Differential Paracrine Role of the Endothelium in Prostate Cancer Cells
Authors: V Torres-Est, M Mastri, S Rosario, P Fuenzalida, CE Echeverría, E Flores, A Watts, J Cerda-Infa, VP Montecinos, PC Sotomayor, J Amigo, C Escudero, F Nualart, JML Ebos, DJ Smiraglia, AS Godoy
Cancers, 2022;14(19):. 2022
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Two New Potential Therapeutic Approaches in Radiation Cystitis Derived from Mesenchymal Stem Cells: Extracellular Vesicles and Conditioned Medium
Authors: C Helissey, N Guitard, H Théry, S Goulinet, P Mauduit, M Girleanu, AL Favier, M Drouet, C Parnot, C Chargari, S Cavallero, S François
Biology, 2022;11(7):. 2022
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Prophylactic role of Korean Red Ginseng in astrocytic mitochondrial biogenesis through HIF-1alpha
Authors: J Park, M Lee, M Kim, S Moon, S Kim, S Kim, SH Koh, YM Kim, YK Choi
Journal of Ginseng Research, 2022;46(3):408-417. 2022
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Melanoma Mediated Disruption of Brain Endothelial Barrier Integrity Is Not Prevented by the Inhibition of Matrix Metalloproteinases and Proteases
Authors: A Anchan, G Finlay, CE Angel, JJW Hucklesby, SE Graham
Biosensors, 2022;12(8):. 2022
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Pericytes take up and degrade alpha-synuclein but succumb to apoptosis under cellular stress
Authors: TJ Stevenson, RH Johnson, J Savistchen, J Rustenhove, Z Woolf, LCD Smyth, HC Murray, RLM Faull, J Correia, P Schweder, P Heppner, C Turner, R Melki, BV Dieriks, MA Curtis, M Dragunow
Scientific Reports, 2022;12(1):17314. 2022
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ADSCs stimulated by resistin promote breast cancer cell malignancy via CXCL5 in a breast cancer coculture model
Authors: YY Wang, AC Hung, YC Wu, S Lo, HD Chen, YK Chen, YC Hsieh, SC Hu, MF Hou, SF Yuan
Scientific Reports, 2022;12(1):15437. 2022
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Interleukin-8 produced from cancer-associated fibroblasts suppresses proliferation of the OCUCh-LM1 cancer cell line
Authors: R Tanaka, K Kimura, S Eguchi, G Ohira, S Tanaka, R Amano, H Tanaka, M Yashiro, M Ohira, S Kubo
BMC Cancer, 2022;22(1):748. 2022
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Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age
Authors: D Delgado, AM Bilbao, M Beitia, A Garate, P Sánchez, I González-B, A Isasti, M López De J, J Zuazo-Ibar, A Montilla, M Domercq, E Capetillo-, G García Del, J Sallés, C Matute, M Sánchez
International Journal of Molecular Sciences, 2021;22(4):. 2021
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Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors: LG Lima, S Ham, H Shin, EPZ Chai, ESH Lek, RJ Lobb, AF Müller, S Mathivanan, B Yeo, Y Choi, BS Parker, A Möller
Nature Communications, 2021;12(1):3543. 2021
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Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: a patient feasibility study
Authors: RLI Crake, MR Strother, E Phillips, MP Doogue, M Zhang, CMA Frampton, BA Robinson, MJ Currie
Scientific Reports, 2021;11(1):5648. 2021
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Combination of Epithelial Growth Factor Receptor Blockers and CDK4/6 Inhibitor for Nasopharyngeal Carcinoma Treatment
Authors: HP Li, CY Huang, KW Lui, YK Chao, CN Yeh, LY Lee, Y Huang, TL Lin, YC Kuo, MY Huang, YR Lai, YM Yeh, HC Fan, AC Lin, JC Hsieh, KP Chang, CY Lin, HM Wang, YS Chang, CL Hsu
Cancers, 2021;13(12):. 2021
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Efficacy of chitinase-3-like protein 1 as an in�vivo bone formation predictable marker of maxillary/mandibular bone marrow stromal cells
Authors: N Komabashir, F Suehiro, M Ishii, M Nishimura
Regenerative Therapy, 2021;18(0):38-50. 2021
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CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1
Authors: S Durlanik, K Fundel-Cle, C Viollet, HJ Huber, M Lenter, K Kitt, S Pflanz
Scientific Reports, 2021;11(1):14849. 2021
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Adhesion strength and contractility enable metastatic cells to become adurotactic
Authors: B Yeoman, G Shatkin, P Beri, A Banisadr, P Katira, AJ Engler
Cell Reports, 2021;34(10):108816. 2021
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Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC
Authors: RN Hawthorne, A Blazeski, J Lowenthal, S Kannan, R Teuben, D DiSilvestr, J Morrissett, JE Saffitz, KR Boheler, CA James, SP Chelko, G Tomaselli, L Tung
Journal of Clinical Medicine, 2021;10(14):. 2021
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Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection
Authors: P Vigneault, S Parent, P Kanda, C Michie, DR Davis, S Nattel
Nature Communications, 2021;12(1):4963. 2021
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CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity
Authors: P Filppu, JT Ramanathan, KJ Granberg, E Gucciardo, H Haapasalo, K Lehti, M Nykter, V Le Joncour, P Laakkonen
JCI Insight, 2021;6(9):. 2021
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Cancer testis antigen PRAME: An anti-cancer target with immunomodulatory potential
Authors: A Naik, R Thomas, G Al-Khadair, R Bacha, W Hendrickx, J Decock
Journal of Cellular and Molecular Medicine, 2021;0(0):. 2021
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Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells
Authors: L Kobari, M Auclair, O Piau, N Ferrand, M Zaoui, F Delhommeau, B Fève, M Sabbah, L Garderet
Leukemia, 2021;0(0):. 2021
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Suprabasin-derived bioactive peptides identified by plasma peptidomics
Authors: T Taguchi, Y Kodera, K Oba, T Saito, Y Nakagawa, Y Kawashima, M Shichiri
Scientific Reports, 2021;11(1):1047. 2021
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Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment
Authors: S Hong, JY You, K Paek, J Park, SJ Kang, EH Han, N Choi, S Chung, WJ Rhee, JA Kim
Theranostics, 2021;11(19):9687-9704. 2021
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Tear-Derived Exosome Proteins Are Increased in Patients with Thyroid Eye Disease
Authors: JS Han, SE Kim, JQ Jin, NR Park, JY Lee, HL Kim, SB Lee, SW Yang, DJ Lim
International Journal of Molecular Sciences, 2021;22(3):. 2021
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Metallothionein 2A Expression in Cancer-Associated Fibroblasts and Cancer Cells Promotes Esophageal Squamous Cell Carcinoma Progression
Authors: M Shimizu, YI Koma, H Sakamoto, S Tsukamoto, Y Kitamura, S Urakami, K Tanigawa, T Kodama, N Higashino, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki
Cancers, 2021;13(18):. 2021
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Transcryptomic Analysis of Human Brain-Microvascular Endothelial Response to -Pericytes: Cell Orientation Defines Barrier Function
Authors: L Kurmann, M Okoniewski, OO Ogunshola, B Leeners, B Imthurn, RK Dubey
Cells, 2021;10(4):. 2021
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Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
Authors: M Bolis, D Bossi, A Vallerga, V Ceserani, M Cavalli, D Impellizzi, L Di Rito, E Zoni, S Mosole, AR Elia, A Rinaldi, R Pereira Me, E D'Antonio, M Ferrari, F Stoffel, F Jermini, S Gillessen, L Bubendorf, P Schraml, A Calcinotto, E Corey, H Moch, M Spahn, G Thalmann, M Kruithof-d, MA Rubin, JP Theurillat
Nature Communications, 2021;12(1):7033. 2021
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Transcryptomic Analysis of Human Brain -Microvascular Endothelial Cell Driven Changes in -Vascular Pericytes
Authors: L Kurmann, M Okoniewski, RK Dubey
Cells, 2021;10(7):. 2021
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Diphenylarsinic acid induced activation of MAP kinases, transcription factors, and oxidative stress-responsive factors and hypersecretion of cytokines in cultured normal human cerebellar astrocytes
Authors: S Sasaki, T Negishi, T Tsuzuki, K Yukawa
Neurotoxicology, 2021;88(0):196-207. 2021
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C-C Motif Chemokine Ligand-17 as a Novel Biomarker and Regulator of Epithelial Mesenchymal Transition in Renal Fibrogenesis
Authors: YH Hsieh, WC Wang, TW Hung, CC Lee, JP Tsai
Cells, 2021;10(12):. 2021
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Reduction of Oxidative Stress in Peripheral Blood Mononuclear Cells Attenuates the Inflammatory Response of Fibroblast-like Synoviocytes in Rheumatoid Arthritis
Authors: HR Lee, SJ Yoo, J Kim, CK Park, SW Kang
International Journal of Molecular Sciences, 2021;22(22):. 2021
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Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer
Authors: WX Peng, P Koirala, H Zhou, J Jiang, Z Zhang, L Yang, YY Mo
Cell Death & Disease, 2021;12(11):1000. 2021
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Gelatin methacrylate hydrogels culture model for glioblastoma cells enriches for mesenchymal-like state and models interactions with immune cells
Authors: N Shah, PM Hallur, RA Ganesh, P Sonpatki, D Naik, KP Chandracha, RB Puchalski, A Chaubey
Scientific Reports, 2021;11(1):17727. 2021
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GSTM1 Modulates Expression of Endothelial Adhesion Molecules in Uremic Milieu
Authors: D Jerotic, S Suvakov, M Matic, A Alqudah, DJ Grieve, M Pljesa-Erc, A Savic-Rado, T Damjanovic, N Dimkovic, L McClements, T Simic
Oxidative Medicine and Cellular Longevity, 2021;2021(0):6678924. 2021
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Isolation and Characterization of Human Synovial Fluid-Derived Mesenchymal Stromal Cells from Popliteal Cyst
Authors: F Li, J Chen, M Gong, Y Bi, C Hu, Y Zhang, M Li
Stem Cells Int, 2020;2020(0):7416493. 2020
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Unique inflammatory signature in haemophilic arthropathy: miRNA changes due to interaction between blood and fibroblast-like synoviocytes
Authors: S Mignot, N Cagnard, B Albaud, C Bally, J Siavellis, O Hermine, L Frenzel
J Cell Mol Med, 2020;0(0):. 2020
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Tissue cytokine/chemokine profile in vulvar lichen sclerosus: An observational study on keratinocyte and fibroblast cultures
Authors: M Corazza, L Oton-Gonza, V Scuderi, JC Rotondo, C Lanzillott, G Di Mauro, M Tognon, F Martini, A Borghi
J Dermatol Sci, 2020;0(0):. 2020
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Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia
Authors: HH Park, HN Kim, H Kim, Y Yoo, H Shin, EY Choi, JS Bae, W Lee
Sci Adv, 2020;6(31):. 2020
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Oxidative stress-mediated mitochondrial dysfunction facilitates mesenchymal stem cell senescence in ankylosing spondylitis
Authors: G Ye, Z Xie, H Zeng, P Wang, J Li, G Zheng, S Wang, Q Cao, M Li, W Liu, S Cen, Z Li, Y Wu, Z Ye, H Shen
Cell Death Dis, 2020;11(9):775. 2020
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Excess of the NF-?B p50 subunit generated by the ubiquitin ligase KPC1 suppresses tumors via PD-L1- and chemokines-mediated mechanisms
Authors: Y Kravtsova-, G Goldhirsh, A Ivantsiv, O Ben Itzhak, YT Kwon, E Pikarsky, A Ciechanove
Proc Natl Acad Sci U S A, 2020;0(0):. 2020
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Serum-Derived Exosomal MicroRNA Profiles Can Predict Poor Survival Outcomes in Patients with Extranodal Natural Killer/T-Cell Lymphoma
Authors: KJ Ryu, JY Lee, ME Choi, SE Yoon, J Cho, YH Ko, JH Shim, WS Kim, C Park, SJ Kim
Cancers, 2020;12(12):. 2020
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Glycosaminoglycans as Tools to Decipher the Platelet Tumor Cell Interaction: A Focus on P-Selectin
Authors: S Schwarz, LM Gockel, A Naggi, U Barash, M Gobec, G Bendas, M Schlesinge
Molecules, 2020;25(5):. 2020
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Regulation of PD-L1 expression is a novel facet of cyclic-AMP-mediated immunosuppression
Authors: B Sasi, P Ethiraj, J Myers, AP Lin, S Jiang, Z Qiu, KN Holder, RCT Aguiar
Leukemia, 2020;0(0):. 2020
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Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages
Authors: YY Wang, HD Chen, S Lo, YK Chen, YC Huang, SC Hu, YC Hsieh, AC Hung, MF Hou, SF Yuan
Cancers, 2020;12(12):. 2020
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Resveratrol as Inducer of Autophagy, Pro-Survival, and Anti-Inflammatory Stimuli in Cultured Human RPE Cells
Authors: N Josifovska, R Albert, R Nagymihály, L Lytvynchuk, MC Moe, K Kaarnirant, ZJ Veréb, G Petrovski
Int J Mol Sci, 2020;21(3):. 2020
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SFMBT2-Mediated Infiltration of Preadipocytes and TAMs in Prostate Cancer
Authors: J Gwak, H Jeong, K Lee, JY Shin, T Sim, J Na, J Kim, BG Ju
Cancers, 2020;12(9):. 2020
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Anti-EGFR Therapy Induces EGF Secretion by Cancer-Associated Fibroblasts to Confer Colorectal Cancer Chemoresistance
Authors: CM Garvey, R Lau, A Sanchez, RX Sun, EJ Fong, ME Doche, O Chen, A Jusuf, HJ Lenz, B Larson, SM Mumenthale
Cancers (Basel), 2020;12(6):. 2020
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Cytokine changes during treatment of anti-Caspr2 encephalitis: a case report
Authors: YC Wei, CL Wu, WC Weng
BMC Neurol, 2020;20(1):299. 2020
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Chemerin-156 is the Active Isoform in Human Hepatic Stellate Cells
Authors: M Spirk, S Zimny, M Neumann, N McMullen, CJ Sinal, C Buechler
Int J Mol Sci, 2020;21(20):. 2020
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Vadadustat, a HIF Prolyl Hydroxylase Inhibitor, Improves Immunomodulatory Properties of Human Mesenchymal Stromal Cells
Authors: K Zielniok, A Burdzinska, B Kaleta, R Zagozdzon, L Paczek
Cells, 2020;9(11):. 2020
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Zoledronic Acid Abrogates Restraint Stress-Induced Macrophage Infiltration, PDGF-AA Expression, and Ovarian Cancer Growth
Authors: CB Colon-Eche, T Ortiz, L Maldonado, MJ Hidalgo-Va, J Pérez-Mora, AN Aquino-Ace, R Herrera-No, M Bonilla-Cl, EM Castro, GN Armaiz-Pen
Cancers, 2020;12(9):. 2020
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TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades
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Oncotarget, 2020;11(21):1961-1970. 2020
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Reproducibility of GMP-compliant production of therapeutic stressed peripheral blood mononuclear cell-derived secretomes, a novel class of biological medicinal products
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Stem Cell Res Ther, 2020;11(1):9. 2020
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Impact of Type 2 Diabetes Mellitus on Human Bone Marrow Stromal Cell Number and Phenotypic Characteristics
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Int J Mol Sci, 2020;21(7):. 2020
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Progenitor Cells Activated by Platelet Lysate in Human Articular Cartilage as a Tool for Future Cartilage Engineering and Reparative Strategies
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Cells, 2020;9(4):. 2020
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Human amniotic mesenchymal stromal cells promote bone regeneration via activating endogenous regeneration
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Theranostics, 2020;10(14):6216-6230. 2020
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Intermittent hypoxia modulates redox homeostasis, lipid metabolism associated inflammatory processes and redox post-translational modifications: Benefits at high altitude
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Sci Rep, 2020;10(1):7899. 2020
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Intrathecal Infusion of Autologous Adipose-Derived Regenerative Cells in Autoimmune Refractory Epilepsy: Evaluation of Safety and Efficacy
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Modulating Tumor-Associated Macrophage Polarization by Synthetic and Natural PPAR&gamma Ligands as a Potential Target in Breast Cancer
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Cells, 2020;9(1):. 2020
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Anti-CD3 Antibody Treatment Reduces Scar Formation in a Rat Model of Myocardial Infarction
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Cells, 2020;9(2):. 2020
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Permanent Pro-Tumorigenic Shift in Adipose Tissue-Derived Mesenchymal Stromal Cells Induced by Breast Malignancy
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Cells, 2020;9(2):. 2020
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Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts
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Br. J. Cancer, 2020;0(0):. 2020
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Astrogliosis Releases Pro-Oncogenic Chitinase 3-Like 1 Causing MAPK Signaling in Glioblastoma
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Cancers (Basel), 2019;11(10):. 2019
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Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice
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EBioMedicine, 2019;44(0):452-466. 2019
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Abnormal inhibition of osteoclastogenesis by mesenchymal stem cells through the miR-4284/CXCL5 axis in ankylosing spondylitis
Authors: W Liu, P Wang, Z Xie, S Wang, M Ma, J Li, M Li, S Cen, S Tang, G Zheng, G Ye, X Wu, Y Wu, H Shen
Cell Death Dis, 2019;10(3):188. 2019
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Blockage of TGF-? Induced by Spherical Silica Nanoparticles Inhibits Epithelial-Mesenchymal Transition and Proliferation of Human Lung Epithelial Cells
Authors: Y Li, H Li, Y Duan, X Cai, D You, F Zhou, C Yang, X Tuo, Z Liu
Biomed Res Int, 2019;2019(0):8231267. 2019
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Ectoine-Containing Inhalation Solution versus Saline Inhalation Solution in the Treatment of Acute Bronchitis and Acute Respiratory Infections: A Prospective, Controlled, Observational Study
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Biomed Res Int, 2019;2019(0):7945091. 2019
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Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
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Stem Cell Res Ther, 2019;10(1):100. 2019
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p16INK4A-expressing mesenchymal stromal cells restore the senescence-clearance-regeneration sequence that is impaired in chronic muscle inflammation
Authors: TS Chikenji, Y Saito, N Konari, M Nakano, Y Mizue, M Otani, M Fujimiya
EBioMedicine, 2019;0(0):. 2019
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Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma
Authors: D Henrik Hei, VM Ravi, SP Behringer, JH Frenking, J Wurm, K Joseph, NWC Garrelfs, J Strähle, S Heynckes, J Grauvogel, P Franco, I Mader, M Schneider, AL Potthoff, D Delev, UG Hofmann, C Fung, J Beck, R Sankowski, M Prinz, O Schnell
Nat Commun, 2019;10(1):2541. 2019
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Obesity in acute alcoholic hepatitis increases morbidity and mortality
Authors: R Parker, SJ Kim, GY Im, J Nahas, B Dhesi, N Vergis, A Sinha, A Ghezzi, MR Rink, A McCune, GP Aithal, PN Newsome, CJ Weston, A Holt, B Gao
EBioMedicine, 2019;45(0):511-518. 2019
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The Secretomes of Painful Versus Nonpainful Human Schwannomatosis Tumor Cells Differentially Influence Sensory Neuron Gene Expression and Sensitivity
Authors: KL Ostrow, KJ Donaldson, MJ Caterina, A Belzberg, A Hoke
Sci Rep, 2019;9(1):13098. 2019
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The Differences in the Characteristics of Insulin-producing Cells Using Human Adipose-tissue Derived Mesenchymal Stem Cells from Subcutaneous and Visceral Tissues
Authors: Y Wada, T Ikemoto, Y Morine, S Imura, Y Saito, S Yamada, M Shimada
Sci Rep, 2019;9(1):13204. 2019
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The Composition of Hyperacute Serum and Platelet-Rich Plasma Is Markedly Different despite the Similar Production Method
Authors: D Kardos, M Simon, G Vácz, A Hinsenkamp, T Holczer, D Cseh, A Sárközi, K Szenthe, F Bánáti, S Szathmary, S Nehrer, O Kuten, M Masteling, Z Lacza, I Hornyák
Int J Mol Sci, 2019;20(3):. 2019
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Hypoxia Rapidly Induces the Expression of Cardiomyogenic Factors in Human Adipose-Derived Adherent Stromal Cells
Authors: JW Choi, H Moon, SE Jung, S Lim, S Lee, IK Kim, HB Lee, J Lee, BW Song, SW Kim, KC Hwang
J Clin Med, 2019;8(8):. 2019
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Tissue-regenerative potential of the secretome of gamma-irradiated peripheral blood mononuclear cells is mediated via TNFRSF1B-induced necroptosis
Authors: E Simader, L Beer, M Laggner, V Vorstandle, A Gugerell, M Erb, P Kalinina, D Copic, D Moser, A Spittler, E Tschachler, H Jan Ankers, M Mildner
Cell Death Dis, 2019;10(10):729. 2019
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Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development
Authors: O Malaise, Y Tachikart, M Constantin, M Mumme, R Ferreira-L, S Noack, C Krettek, D Noël, J Wang, C Jorgensen, JM Brondello
Aging (Albany NY), 2019;11(20):9128-9146. 2019
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Physiologic expansion of human heart-derived cells enhances therapeutic repair of injured myocardium
Authors: S Mount, P Kanda, S Parent, S Khan, C Michie, L Davila, V Chan, RA Davies, H Haddad, D Courtman, DJ Stewart, DR Davis
Stem Cell Res Ther, 2019;10(1):316. 2019
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Radiotherapy-Induced Changes in the Systemic Immune and Inflammation Parameters of Head and Neck Cancer Patients
Authors: K Balázs, E Kis, C Badie, EN Bogdándi, S Candéias, LC Garcia, I Dominczyk, B Frey, U Gaipl, Z Jurányi, ZS Kocsis, EA Rutten, G Sáfrány, P Widlak, K Lumniczky
Cancers (Basel), 2019;11(9):. 2019
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Inflammation-Related Patterns in the Clinical Staging and Severity Assessment of Chronic Kidney Disease
Authors: S Mihai, E Codrici, ID Popescu, AM Enciu, E Rusu, D Zilisteanu, LG Necula, G Anton, C Tanase
Dis. Markers, 2019;2019(0):1814304. 2019
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Extracellular Membrane Vesicles from Lactobacilli Dampen IFN-gamma Responses in a Monocyte-Dependent Manner
Authors: M Mata Forsb, S Björkander, Y Pang, L Lundqvist, M Ndi, M Ott, IB Escribá, MC Jaeger, S Roos, E Sverremark
Sci Rep, 2019;9(1):17109. 2019
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CCR2 signaling in breast carcinoma cells promotes tumor growth and invasion by promoting CCL2 and suppressing CD154 effects on the angiogenic and immune microenvironments
Authors: G Brummer, W Fang, C Smart, B Zinda, N Alissa, C Berkland, D Miller, N Cheng
Oncogene, 2019;0(0):. 2019
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PRMT6 promotes lung tumor progression via the alternate activation of tumor-associated macrophages
Authors: S Avasarala, PY Wu, SQ Khan, S Yanlin, M Van Scoyk, J Bao, A Di Lorenzo, O David, MT Bedford, V Gupta, RA Winn, RK Bikkavilli
Mol. Cancer Res., 2019;0(0):. 2019
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Interleukin-6 mediates resistance to PI3K-pathway-targeted therapy in lymphoma
Authors: JH Kim, WS Kim, C Park
BMC Cancer, 2019;19(1):936. 2019
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Obesity in acute alcoholic hepatitis increases morbidity and mortality
Authors: R Parker, SJ Kim, GY Im, J Nahas, B Dhesi, N Vergis, A Sinha, A Ghezzi, MR Rink, A McCune, GP Aithal, PN Newsome, CJ Weston, A Holt, B Gao
EBioMedicine, 2019;45(0):511-518. 2019
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Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis
Authors: P Garcia-Rei, A Phillips, TM Piers, C Villegas-L, M Butler, A Mallach, C Rodrigues, CE Arber, A Heslegrave, H Zetterberg, H Neumann, S Neame, H Houlden, J Hardy, JM Pocock
Cell Rep, 2018;24(9):2300-2311. 2018
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Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy
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Nat Commun, 2018;9(1):3267. 2018
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Microgravity-Induced Alterations of Inflammation-Related Mechanotransduction in Endothelial Cells on Board SJ-10 Satellite
Authors: N Li, C Wang, S Sun, C Zhang, D Lü, Q Chen, M Long
Front Physiol, 2018;9(0):1025. 2018
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Mesenchymal stem cells over-expressing cxcl12 enhance the radioresistance of the small intestine
Authors: P Chang, B Zhang, L Shao, W Song, W Shi, L Wang, T Xu, D Li, X Gao, Y Qu, L Dong, J Wang
Cell Death Dis, 2018;9(2):154. 2018
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Gle1 mediates stress granule-dependent survival during chemotoxic stress
Authors: L Glass, SR Wente
Adv Biol Regul, 2018;0(0):. 2018
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Neurofibromin knockdown in glioma cell lines is associated with changes in cytokine and chemokine secretion in vitro
Authors: MD Wood, J Mukherjee, RO Pieper
Sci Rep, 2018;8(1):5805. 2018
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Increased Dkk-1 plasma levels may discriminate disease subtypes in myeloproliferative neoplasms
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J. Cell. Mol. Med., 2018;0(0):. 2018
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ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation
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Sci Rep, 2018;8(1):1431. 2018
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IL-23 secreted by myeloid cells drives castration-resistant prostate cancer
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Nature, 2018;0(0):. 2018
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Epithelial cell-derived cytokines CST3 and GDF15 as potential therapeutics for pulmonary fibrosis
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Cell Death Dis, 2018;9(5):506. 2018
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Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1
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Sci Adv, 2018;4(2):e1701729. 2018
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Unique and shared inflammatory profiles of human brain endothelia and pericytes
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J Neuroinflammation, 2018;15(1):138. 2018
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Efficient scalable production of therapeutic microvesicles derived from human mesenchymal stem cells
Authors: JM Cha, EK Shin, JH Sung, GJ Moon, EH Kim, YH Cho, HD Park, H Bae, J Kim, OY Bang
Sci Rep, 2018;8(1):1171. 2018
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A Transient Pseudosenescent Secretome Promotes Tumor Growth after Antiangiogenic Therapy Withdrawal
Authors: M Mastri, A Tracz, CR Lee, M Dolan, K Attwood, JG Christense, S Liu, JML Ebos
Cell Rep, 2018;25(13):3706-3720.e8. 2018
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CST3 and GDF15 ameliorate renal fibrosis by inhibiting fibroblast growth and activation
Authors: YI Kim, HW Shin, YS Chun, JW Park
Biochem. Biophys. Res. Commun., 2018;0(0):. 2018
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Withaferin A Associated Differential Regulation of Inflammatory Cytokines
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Front Immunol, 2018;9(0):195. 2018
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Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration
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Am. J. Pathol., 2018;188(4):950-966. 2018
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Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion
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Sci Rep, 2018;8(1):17058. 2018
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Hypoxia-induced upregulation of angiogenic factors in immortalized human periodontal ligament fibroblasts
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J Oral Sci, 2018;60(4):519-525. 2018
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Acid-electrolyzed functional water induces extracellular matrix metalloproteinase inducer, a possible novel alarmin, secretion from oral squamous cell carcinoma cell lines
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Int J Med Sci, 2018;15(12):1365-1372. 2018
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Ca2+ Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2
Authors: K Eubler, C Herrmann, A Tiefenbach, FM Köhn, JU Schwarzer, L Kunz, A Mayerhofer
Int J Mol Sci, 2018;19(9):. 2018
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USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and ?-TrCP and promotes cancer malignancy
Authors: YC Wang, YS Wu, CY Hung, SA Wang, MJ Young, TI Hsu, JJ Hung
Nat Commun, 2018;9(1):3996. 2018
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Circulating monocytes from prostate cancer patients promote invasion and motility of epithelial cells
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Cancer Med, 2018;0(0):. 2018
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A static magnetic field inhibits the expression of platelet-derived growth factor-AA in human oral squamous cell carcinoma
Authors: M Obayashi-I, S Saito, D Omagari, M Asano, T Ishigami
J Oral Sci, 2018;0(0):. 2018
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Extravillous Trophoblast and Endothelial Cell Crosstalk Mediates Leukocyte Infiltration to the Early Remodeling Decidual Spiral Arteriole Wall
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J. Immunol., 2017;0(0):. 2017
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Obesity Enhances the Conversion of Adipose-Derived Stromal/Stem Cells into Carcinoma-Associated Fibroblast Leading to Cancer Cell Proliferation and Progression to an Invasive Phenotype
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Stem Cells Int, 2017;2017(0):9216502. 2017
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Histone Deacetylase 1 Depletion Activates Human Cardiac Mesenchymal Stromal Cell Proangiogenic Paracrine Signaling Through a Mechanism Requiring Enhanced Basic Fibroblast Growth Factor Synthesis and Secretion
Authors: JB Moore, J Zhao, AG Fischer, MCL Keith, D Hagan, M Wysoczynsk, R Bolli
J Am Heart Assoc, 2017;6(7):. 2017
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Crosstalk between stromal components and tumor cells of TNBC via secreted factors enhances tumor growth and metastasis
Authors: K Jin, NB Pandey, AS Popel
Oncotarget, 2017;0(0):. 2017
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Protective Effect of Let-7 miRNA Family in Regulating Inflammation in Diabetes-Associated Atherosclerosis
Authors: E Brennan, B Wang, A McClelland, M Mohan, M Marai, O Beuscart, S Derouiche, S Gray, R Pickering, C Tikellis, M de Gaetano, M Barry, O Belton, ST Ali-Shah, P Guiry, KA Jandeleit-, ME Cooper, C Godson, P Kantharidi
Diabetes, 2017;0(0):. 2017
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Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction
Authors: S Chandran, J Watkins, A Abdul-Aziz, M Shafat, PA Calvert, KM Bowles, MD Flather, SA Rushworth, AD Ryding
J Am Heart Assoc, 2017;6(5):. 2017
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Lack of Evidence for Vasoactive and Inflammatory Mediators in the Promotion of Macular Edema Associated with Epiretinal Membranes
Authors: BP Applewhite, S Babapoor-F, D Poon, SJ Hassan, E Wellmann, HS Ying, GL Semenza, S Montaner, A Sodhi
Sci Rep, 2017;7(1):10608. 2017
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An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells
Authors: A Sasahara, K Tominaga, T Nishimura, M Yano, E Kiyokawa, M Noguchi, M Noguchi, H Kanauchi, T Ogawa, H Minato, K Tada, Y Seto, A Tojo, N Gotoh
Oncotarget, 2017;8(15):24869-24881. 2017
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Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages
Sci Rep, 2016;6(0):29588. 2016
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Identification of Pathways in Liver Repair Potentially Targeted by Secretory Proteins from Human Mesenchymal Stem Cells
Int J Mol Sci, 2016;17(7):. 2016
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Pretreatment of IL-1? enhances proliferation and chondrogenic potential of synovium-derived mesenchymal stem cells
Authors: Etsuko Matsumura
Cytotherapy, 2016;0(0):. 2016
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Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer
Oncotarget, 2016;0(0):. 2016
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Diesel Exhaust Particles Upregulate Interleukins IL-6 and IL-8 in Nasal Fibroblasts
Authors: Jin Ah Kim
PLoS ONE, 2016;11(6):e0157058. 2016
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Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer
Nature, 2016;533(7604):493-8. 2016
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Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.
Authors: Westman J, Papareddy P, Dahlgren M, Chakrakodi B, Norrby-Teglund A, Smeds E, Linder A, Morgelin M, Johansson-Lindbom B, Egesten A, Herwald H
PLoS Pathog, 2015;11(12):e1005319. 2015
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VSIG-3 as a ligand of VISTA inhibits human T-cell function.
Authors: Wang J, Wu G, Manick B, Hernandez V, Renelt M, Erickson C, Guan J, Singh R, Rollins S, Solorz A, Bi M, Li J, Grabowski D, Dirkx J, Tracy C, Stuart T, Ellinghuysen C, Desmond D, Foster C, Kalabokis V
Immunology, 0;156(1):74-85. 0
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