Detection of CXCR6 in HEK293 Human Cell Line Transfected with Rat CXCR6 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with rat CXCR6 and eGFP was stained with either (A) Mouse Anti-Rat CXCR6 Monoclonal Antibody (Catalog # MAB8196) or (B) Mouse IgG1 Isotype Control (Catalog # MAB002) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B).
Preparation and Storage
Reconstitute at 0.5 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
CXCR6, also known as BONZO, STRL33, and CD186, is an approximately 45 kDa 7-TM domain chemokine receptor for the membrane-bound and soluble forms of CXCL16. CXCR6 is expressed on monocytes as well as on NKT, NK, CD4+, and CD8+ T cells. It is upregulated in a variety of cancers. CXCR6 mediates the recruitment of immune cells to sites of inflammation and tissue damage. It also promotes NK cell memory and tolerance to NKT cell-mediated graft rejection. CXCR6 enhances the invasiveness of both tumor cells and glial precursor cells. In addition, it can function as a cellular receptor for select variants of HIV types 1 and 2. Rat CXCR6 shares 72% and 88% amino acid sequence identity with human and mouse CXCR6, respectively.
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