Rat CXCR6 Antibody Summary
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of CXCR6 in HEK293 Human Cell Line Transfected with Rat CXCR6 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with rat CXCR6 and eGFP was stained with either (A) Mouse Anti-Rat CXCR6 Monoclonal Antibody (Catalog # MAB8196R) or (B) Mouse IgG1 Isotype Control (Catalog # MAB002) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
CXCR6, also known as BONZO, STRL33, and CD186, is an approximately 45 kDa 7-TM domain chemokine receptor for the membrane-bound and soluble forms of CXCL16. CXCR6 is expressed on monocytes as well as on NKT, NK, CD4+, and CD8+ T cells. It is up-regulated in a variety of cancers. CXCR6 mediates the recruitment of immune cells to sites of inflammation and tissue damage. It also promotes NK cell memory and tolerance to NKT cell-mediated graft rejection. CXCR6 enhances the invasiveness of both tumor cells and glial precursor cells. In addition, it can function as a cellular receptor for select variants of HIV types 1 and 2. Rat CXCR6 shares 72% and 88% amino acid sequence identity with human and mouse CXCR6, respectively.
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