R&D Systems Cytokines & Growth Factors

Setting the Standard for the Life Science Industry for over 25 Years

R&D Systems is focused on providing the highest quality products for cytokine & growth factor research


Natural TGF-beta was first purified and sold by R&D Systems in 1986 followed by the release of our first recombinant proteins in 1988. Today with over 25 years of experience in the industry, we offer more than 3,000 bioactive recombinant proteins from 16 different species. Additionally, we offer over 300 Quantikine® ELISA Kits, 1,000 DuoSet® ELISA Development Systems, 50 Multianalyte Profiling Kits, and 12,500 antibodies qualified for multiple applications including blocking/neutralization, flow cytometry, immunohistochemistry, and Western blot.


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Activity Comparison Data for Recombinant Mouse Wnt‑3a. The MC3T3-E1 mouse preosteoblast cell line was treated with increasing concentrations of R&D Systems Recombinant Mouse Wnt‑3a (Catalog # 1324-WN) or with mouse Wnt-3a from two other companies. The R&D Systems protein shows greater than a four-fold increase in activity compared to the other commercially available proteins.


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SDS-PAGE Analysis of High Purity Recombinant Mouse Wnt‑3a. High Purity Recombinant Mouse Wnt‑3a (Catalog # 1324-WNP; 1 µg/lane) was loaded on a 12% SDS-PAGE gel under reducing conditions and visualized by silver staining.

 

We are the most referenced manufacturer of recombinant proteins & ELISA Kits


More than 97% of the products available from R&D Systems are developed and manufactured at our own facility, enabling us to maintain strict manufacturing and quality control standards. Our dedication to product quality is evidenced by the fact that our recombinant proteins and ELISA Kits are cited in the scientific literature more than those from any other protein or ELISA Kit manufacturer.


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R&D Systems is the Most Referenced ELISA Manufacturer. A literature survey was conducted to determine the number of publications citing the use of R&D Systems ELISA Kits compared to the number referencing ELISA Kits obtained from other companies. The survey included 860 manuscripts that were published in one of 44 high impact journals from several different general research areas including immunology, signal transduction, development, neuroscience, bone/endocrinology, and hematology. A total of 433 ELISA Kit citations were identified in the survey and approximately 42% referenced products manufactured by R&D Systems.

Our scientists are dedicated to developing the highest quality products & new processes that meet the needs of researchers including high purity proteins, traditional & cell culture grade • Animal-free proteins • GMP proteins


By staying current with the literature, we identify the areas of science that researchers are interested in and develop superior products that allow them to further their studies. This commitment to science provides a rapidly expanding selection of new products. If we do not offer a reagent that you need, we are always open to product suggestions made by our customers (www.RnDSystems.com/Suggestion).

We recognize active areas of science and develop superior products that meet the needs of researchers.


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Bioactivity of Recombinant Human IL‑17A/F Heterodimer. Recombinant Human IL‑17A/F Heterodimer (Catalog # 5837‑IL) stimulates IL‑6 secretion by NIH-3T3 mouse embryonic fibroblast cell line.


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Purity of Recombinant Human IL‑17A/F. 1 μg of Recombinant Human IL‑17A/F (Catalog # 5837‑IL) was loaded onto an SDS-PAGE gel under reducing (R) and non-reducing (NR) conditions and visualized by silver staining.

 

We develop new processes to produce high performance proteins that comply with stringent regulatory requirements.

Animal-free proteins


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Bioactivity of Animal-free Recombinant Human/Mouse/Rat Activin A. Animal-free Recombinant Human/Mouse/Rat Activin A (Catalog # ACFP338) induces hemoglobin expression in K562 human chronic myelogenous leukemia cells.


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Purity of Animal-free Recombinant Human/Mouse/Rat Activin A. 1 μg of Animal-free Recombinant Human/Mouse/Rat Activin A (Catalog # ACFP338) was loaded onto an SDS-PAGE gel under reducing (R) and non-reducing (NR) conditions and visualized by silver staining.

 

GMP-grade proteins NEW!


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Bioactivity of GMP-grade Recombinant
Human IL‑4.
Recombinant Human IL‑4 (Catalog # 204-GMP) stimulates proliferation of TF-1 cells. The ED50 is typically 0.05-0.2 ng/mL.


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Purity of GMP-grade Recombinant Human IL‑4. 1 µg of Recombinant Human IL‑4
(Catalog # 204-GMP) was loaded onto an SDS-PAGE gel under reducing conditions and visualized by silver staining. The purity is > 97%.

 

Select Publications Citing R&D Systems Products for Cytokine & Growth Factor Research


  1. Pathogen-induced human Th17 cells produce IFN-gamma or IL-10 and are regulated by IL-1 beta.
    Zielinski, C.E. et al. Nature 2012 484:514.
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  2. ZNRF3 promotes Wnt receptor turnover in an R-Spondin-sensitive manner.
    Hao, H.X. et al. Nature 2012 485:195.
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  3. Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signaling.
    Benedito, R. et al. Nature 2012 484:110.
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  4. Mycobacterium bovis bacilli Calmette-Guerin regulates leukocyte recruitment by modulating alveolar inflammatory responses.
    Andersson, M. et al. Innate Immun. 2012 18:531.
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  5. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
    Bruchard, M. et al. Nat. Med. 2013 19:57.
    See Details

  6. An epigenetic silencing pathway controlling T helper 2 cell lineage commitment.
    Allen, R.S. et al. Nature 2012 487:249.
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  7. Osteoprotection by semaphorin 3A.
    Hayashi, M. et al. Nature 2012 485:69.
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  8. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Wilson, T.R. et al. Nature 2012 487:505.
    See Details

For a complete listing of Cytokine & Growth Factor products, please visit our Cytokines & Growth Factors Research Topic page at www.RnDSystems.com/CytokineGF