Recombinant Human IGF-I Protein, CF

  (98 citations)
(2 Reviews)
    
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Product Details
Citations (98)
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  • Purity
    >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
  • Endotoxin Level
    <0.10 EU per 1 μg of the protein by the LAL method.
  • Activity
    Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is 0.3-1.5 ng/mL.
    The specific activity of recombinant human IGF-l is approximately 2.5 IU/μg, which is calibrated against recombinant human IGF-l WHO International Standard (NIBSC code: 91/554).
  • Source
    E. coli-derived human IGF-I protein
    Gly49-Ala118
  • Accession #
  • N-terminal Sequence
    Analysis
    Gly49
  • Predicted Molecular Mass
    7.6 kDa
  • SDS-PAGE
    7 kDa, reducing conditions
Product Datasheets

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291-G1
 
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
 
Reconstitution Reconstitute at 200 μg/mL in sterile PBS.
 
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
 
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
 
Data Images
Recombinant Human IGF-I (Catalog # 291-G1) stimulates proliferation in the MCF-7 human breast cancer cell line. The ED50 for this effect is 0.3‑1.5 ng/mL.
1 μg/lane of Recombinant Human IGF-I was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 7 kDa.
MALDI-TOF analysis of Recombinant Human IGF-I.The major peak corresponds to the calculated molecular mass, 7650 Da. The minor peak at 7873 is a matrix-associated artifact of the MALDI-TOF.
Background: IGF-I

Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-I is synthesized as two precursor isoforms with N- and alternate C‑terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF‑I is identical between isoforms and is generated by proteolytic removal of the N- and C‑terminal regions. Mature human IGF-I shares 94% and 96% aa sequence identity with mouse and rat IGF-I, respectively (2), and exhibits cross-species activity. It shares 64% aa sequence identity with mature human IGF‑II. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects (1). IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4‑7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). IGF-I association with IGF binding proteins increases its plasma half‑life and modulates its interactions with receptors (10).

  • References:
    1. Philippou, A. et al. (2007) In Vivo 21:45.
    2. Sandberg-Nordqvist, A.C. et al. (1992) Brain Res. Mol. Brain Res. 12:275.
    3. Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890.
    4. Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620.
    5. Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577.
    6. Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275.
    7. Malemud, C.J. (2007) Clin. Chim. Acta 375:10.
    8. Samani, A.A. et al. (2007) Endocrine Rev. 28:20.
    9. LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302.
    10. Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421.
  • Long Name:
    Insulin-like Growth Factor I
  • Entrez Gene IDs:
    3479 (Human); 16000 (Mouse); 24482 (Rat)
  • Alternate Names:
    IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C
Related Research Areas
Citations:

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

98 Citations: Showing 1 - 10
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Species
Applications
Sample Type
  1. In Vitro Regeneration of Patient-specific Ear-shaped Cartilage and Its First Clinical Application for Auricular Reconstruction
    Authors: G Zhou, H Jiang, Z Yin, Y Liu, Q Zhang, C Zhang, B Pan, J Zhou, X Zhou, H Sun, D Li, A He, Z Zhang, W Zhang, W Liu, Y Cao
    EBioMedicine, 2018;28(0):287-302.
    Species: Human
    Sample Type: Complex Sample Type
    Application: Bioassay
  2. Aberrant expression of NKL homeobox gene HLX in Hodgkin lymphoma
    Authors: S Nagel, C Pommerenke, C Meyer, M Kaufmann, RAF MacLeod, HG Drexler
    Oncotarget, 2018;9(18):14338-14353.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  3. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes
    Authors: ZS Nevin, DC Factor, RT Karl, P Douvaras, J Laukka, MS Windrem, SA Goldman, V Fossati, GM Hobson, PJ Tesar
    Am. J. Hum. Genet., 2017;100(4):617-634.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  4. IGF-IR cooperates with ER? to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules
    Authors: NA Afratis, P Bouris, SS Skandalis, HA Multhaupt, JR Couchman, AD Theocharis, NK Karamanos
    Sci Rep, 2017;7(0):40138.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  5. Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders
    Authors: C Lorenz, P Lesimple, R Bukowiecki, A Zink, G Inak, B Mlody, M Singh, M Semtner, N Mah, K Aur‚, M Leong, O Zabiegalov, EM Lyras, V Pfiffer, B Fauler, J Eichhorst, B Wiesner, N Huebner, J Priller, T Mielke, D Meierhofer, Z Izsv k, JC Meier, F Bouillaud, J Adjaye, M Schuelke, EE Wanker, A LombŠs, A Prigione
    Cell Stem Cell, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  6. Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling
    Authors: G Dalton, SW An, SI Al-Juboori, N Nischan, J Yoon, E Dobrinskik, DW Hilgemann, J Xie, K Luby-Phelp, JJ Kohler, L Birnbaumer, CL Huang
    Proc. Natl. Acad. Sci. U.S.A, 2017;114(4):752-757.
    Species: Human
    Sample Type: Whole Cells
    Application: BioassayCell
  7. Experimental Study of the Biological Properties of Human Embryonic Stem Cell-Derived Retinal Progenitor Cells
    Authors: J Shao, PY Zhou, GH Peng
    Sci Rep, 2017;7(0):42363.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  8. Differential involvement of the microtubule cytoskeleton in Insulin Receptor Substrate-1 (IRS-1) and IRS-2 signaling to AKT determines response to microtubule disruption in breast carcinoma cells
    Authors: J Mercado-Ma, JL Clark, AJ Piper, J Janusis, LM Shaw
    J. Biol. Chem, 2017;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  9. Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3
    Authors: H He, AE Kuriyan, CW Su, M Mahabole, Y Zhang, YT Zhu, HW Flynn, JM Parel, SC Tseng
    Sci Rep, 2017;7(0):43736.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  10. Atypical PKC and Notch Inhibition Differentially Modulate Cortical Interneuron Subclass Fate from Embryonic Stem Cells
    Authors: DJ Tischfield, J Kim, SA Anderson
    Stem Cell Reports, 2017;0(0):.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  11. Establishment of an induced pluripotent stem cell (iPSC) line from a 9-year old male with autism spectrum disorder (ASD)
    Authors: E Varga, C Nemes, I Bock, Z Táncos, S Berzsenyi, G Lévay, V Román, J Kobolák, A Dinnyés
    Stem Cell Res, 2017;21(0):19-22.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  12. Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures
    Authors: P Haynes, K Kernan, SL Zhou, DG Miller
    Skelet Muscle, 2017;7(1):13.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  13. Insulin-Like Growth Factor-1 Increases the Expression of Inflammatory Biomarkers and Sebum Production in Cultured Sebocytes
    Authors: H Kim, SY Moon, MY Sohn, WJ Lee
    Ann Dermatol, 2017;29(1):20-25.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  14. Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion
    Authors: T Garrido-Go, K Ona, M Kapidzic, M Gormley, C Simón, O Genbacev, SJ Fisher
    Development, 2017;144(5):767-777.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  15. Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of M�ller Glia-Derived Progenitor Cells in the Avian Retina
    Authors: L Todd, L Suarez, C Quinn, AJ Fischer
    Stem Cells, 2017;0(0):.
    Species: Chicken
    Sample Type: In Vivo
    Application: In Vivo
  16. IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway
    Authors: TT Li, D Zhu, T Mou, Z Guo, JL Pu, QS Chen, XF Wei, ZJ Wu
    Mol. Immunol., 2017;87(0):132-140.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  17. 3D patterned stem cell differentiation using thermo-responsive methylcellulose hydrogel molds
    Sci Rep, 2016;6(0):29408.
    Species: Human
    Sample Type:
  18. Evidence for direct effects of glyphosate on ovarian function: glyphosate influences steroidogenesis and proliferation of bovine granulosa but not theca cells in vitro
    Authors: Maria Chiara Perego
    J Appl Toxicol, 2016;0(0):.
    Species: Bovine
    Sample Type: Whole Cells
    Application: Bioassay
  19. G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications
    Authors: L J Spicer
    Domest. Anim. Endocrinol, 2016;59(0):90-99.
    Species: Bovine
    Sample Type: Whole Cells
    Application: Bioassay
  20. A Collagen Cardiac Patch Incorporating Alginate Microparticles Permits the Controlled Release of HGF and IGF-1 to Enhance Cardiac Stem Cell Migration and Proliferation
    Authors: Hugh S O'Neill
    J Tissue Eng Regen Med, 2016;0(0):.
    Application: Scaffold Fabrication
  21. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
    Authors: Ivan Carcamo-Or
    Cell Stem Cell, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  22. Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration
    Stem Cells Transl Med, 2016;5(5):694-702.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  23. Polyurethane scaffolds seeded with CD34(+) cells maintain early stem cells whilst also facilitating prolonged egress of haematopoietic progenitors
    Sci Rep, 2016;6(0):32149.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  24. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells
    Nat Commun, 2016;7(0):12961.
    Species: Human
    Sample Type:
    Application: Neut
  25. Structural and functional investigations of the effector protein LpiR1 from Legionella pneumophila
    J Biol Chem, 2016;0(0):.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  26. Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma
    Genome Biol, 2016;17(1):80.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  27. Abnormal IGF-Binding Protein Profile in the Bone Marrow of Multiple Myeloma Patients
    Authors: L Bieghs, M Brohus, IB Kristensen, N Abildgaard, M Bøgsted, HE Johnsen, CA Conover, E De Bruyne, K Vanderkerk, MT Overgaard, M Nyegaard
    PLoS ONE, 2016;11(4):e0154256.
    Species: Human
    Sample Type: Plasma
    Application: Bioassay
  28. IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma
    Authors: Matthew N Svalina
    Sci Rep, 2016;6(0):27012.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  29. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5promotes angiogenesis and vasorelaxation.
    Authors: Cho Y, Hur S, Kim J, Kim J, Lee D, Choe J, Won M, Ha K, Jeoung D, Han S, Ryoo S, Lee H, Min J, Kwon Y, Kim D, Kim Y
    J Biol Chem, 2015;290(1):467-77.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  30. Functional EpoR pathway utilization is not detected in primary tumor cells isolated from human breast, non-small cell lung, colorectal, and ovarian tumor tissues.
    Authors: Patterson, Scott D, Rossi, John M, Paweletz, Katherin, Fitzpatrick, V Dan, Begley, C Glenn, Busse, Leigh, Elliott, Steve, McCaffery, Ian
    PLoS ONE, 2015;10(3):e0122149.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  31. Patient-derived xenografts from non-small cell lung cancer brain metastases are valuable translational platforms for the development of personalized targeted therapy.
    Authors: Lee H, Lee J, Lee S, Cho H, Song H, Jeong D, Seo Y, Shin S, Joung J, Kwon Y, Choi Y, Park W, Lee H, Seol H, Shim Y, Joo K, Nam D
    Clin Cancer Res, 2015;21(5):1172-82.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  32. Insulin like growth factor binding protein 7 (IGFBP7) expression is linked to poor prognosis but may protect from bone disease in multiple myeloma.
    Authors: Bolomsky A, Hose D, Schreder M, Seckinger A, Lipp S, Klein B, Heintel D, Ludwig H, Zojer N
    J Hematol Oncol, 2015;8(1):10.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  33. GlcUAbeta1-3Galbeta1-3Galbeta1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1.
    Authors: Izumikawa T, Sato B, Mikami T, Tamura J, Igarashi M, Kitagawa H
    J Biol Chem, 2015;290(9):5438-48.
    Species: Human
    Sample Type: Whole Cells
    Application: cell culture
  34. Insulin-like growth factor-I induces epithelial to mesenchymal transition via GSK-3beta and ZEB2 in the BGC-823 gastric cancer cell line.
    Authors: Li H, Xu L, Zhao L, Ma Y, Zhu Z, Liu Y, Qu X
    Oncol Lett, 2015;9(1):143-148.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  35. IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells.
    Authors: Crosley, Erin J, Dunk, Caroline, Beristain, Alexande, Christians, Julian K
    Reprod Biol Endocrinol, 2015;12(0):123.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  36. EphrinB2 controls vessel pruning through STAT1-JNK3 signalling.
    Authors: Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, Segarra M, Eberhart C, Acker-Palmer A, Tosato G
    Nat Commun, 2015;6(0):6576.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  37. Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.
    Authors: Gori J, Butler J, Chan Y, Chandrasekaran D, Poulos M, Ginsberg M, Nolan D, Elemento O, Wood B, Adair J, Rafii S, Kiem H
    J Clin Invest, 2015;125(3):1243-54.
    Species: Primate - Macaca nemestrina (Southern Pig-tailed Macaque)
    Sample Type: Whole Cells
    Application: Bioassay
  38. Human IGF1 regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi.
    Authors: Drexler A, Pietri J, Pakpour N, Hauck E, Wang B, Glennon E, Georgis M, Riehle M, Luckhart S
    PLoS Pathog, 2014;10(6):e1004231.
    Species: Insect
    Sample Type: In Vivo
    Application: In Vivo
  39. The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
    Authors: Go G, Srivastava R, Hernandez-Ono A, Gang G, Smith S, Booth C, Ginsberg H, Mani A
    Cell Metab, 2014;19(2):209-20.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  40. The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration.
    Authors: Elloul, Sivan, Kedrin, Dmitriy, Knoblauch, Nicholas, Beck, Andrew H, Toker, Alex
    Mol Cancer Res, 2014;12(3):464-76.
  41. Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma.
    Authors: Chinen Y, Kuroda J, Shimura Y, Nagoshi H, Kiyota M, Yamamoto-Sugitani M, Mizutani S, Sakamoto N, Ri M, Kawata E, Kobayashi T, Matsumoto Y, Horiike S, Iida S, Taniwaki M
    Cancer Res, 2014;74(24):7418-29.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  42. Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes.
    Authors: Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H
    Stem Cell Reports, 2014;2(5):648-61.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  43. Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells.
    Authors: Mancini M, Gariboldi M, Taiana E, Bonzi M, Craparotta I, Pagin M, Monti E
    Br J Cancer, 2014;110(12):2865-73.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  44. Epigallocatechin-3-gallate inhibits cell growth, induces apoptosis and causes S phase arrest in hepatocellular carcinoma by suppressing the AKT pathway.
    Authors: Shen X, Zhang Y, Feng Y, Zhang L, Li J, Xie Y, Luo X
    Int J Oncol, 2014;44(3):791-6.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  45. Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells.
    Authors: Pei X, Dai Y, Felthousen J, Chen S, Takabatake Y, Zhou L, Youssefian L, Sanderson M, Bodie W, Kramer L, Orlowski R, Grant S
    PLoS ONE, 2014;9(3):e89064.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  46. Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.
    Authors: Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K
    Cancer Res, 2014;74(16):4458-69.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  47. Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.
    Authors: Cubbon R, Yuldasheva N, Viswambharan H, Mercer B, Baliga V, Stephen S, Askham J, Sukumar P, Skromna A, Mughal R, Walker A, Bruns A, Bailey M, Galloway S, Imrie H, Gage M, Rakobowchuk M, Li J, Porter K, Ponnambalam S, Wheatcroft S, Beech D, Kearney M
    Stem Cells, 2014;32(10):2714-23.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  48. Minimally invasive approach to the repair of injured skeletal muscle with a shape-memory scaffold.
    Authors: Wang, Lin, Cao, Lan, Shansky, Janet, Wang, Zheng, Mooney, David, Vandenburgh, Herman
    Mol Ther, 2014;22(8):1441-9.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  49. CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype.
    Authors: Burnight E, Wiley L, Drack A, Braun T, Anfinson K, Kaalberg E, Halder J, Affatigato L, Mullins R, Stone E, Tucker B
    Gene Ther, 2014;21(7):662-72.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  50. Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells.
    Authors: Li H, Xu L, Li C, Zhao L, Ma Y, Zheng H, Li Z, Zhang Y, Wang R, Liu Y, Qu X
    Mol Cancer, 2014;13(0):136.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  51. Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.
    Authors: Belzile, Jean-Phi, Stark, Thomas J, Yeo, Gene W, Spector, Deborah
    J Virol, 2014;88(8):4021-39.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  52. MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma.
    Authors: Wang, Lu-Kai, Hsiao, Tzu-Hung, Hong, Tse-Ming, Chen, Hsuan-Yu, Kao, Shih-Han, Wang, Wen-Lung, Yu, Sung-Lia, Lin, Ching-We, Yang, Pan-Chyr
    PLoS ONE, 2014;9(5):e96765.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  53. Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.
    Authors: Liang Z, Diepstra A, Xu C, van Imhoff G, Plattel W, Van Den Berg A, Visser L
    PLoS ONE, 2014;9(1):e87474.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  54. Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.
    Authors: Buchholz, David E, Pennington, Britney, Croze, Roxanne, Hinman, Cassidy, Coffey, Peter J, Clegg, Dennis O
    Stem Cells Transl Med, 2013;2(5):384-93.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  55. Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits.
    Authors: Liu Y, Weick J, Liu H, Krencik R, Zhang X, Ma L, Zhou G, Ayala M, Zhang S
    Nat Biotechnol, 2013;31(5):440-7.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  56. Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro.
    Authors: Cardillo T, Trisal P, Arrojo R, Goldenberg D, Chang C
    BMC Cancer, 2013;13(0):170.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  57. Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells.
    Authors: Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S
    Elife, 2013;2(0):e00940.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  58. Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells.
    Authors: Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y
    Mol Ther, 2013;21(1):228-39.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  59. Selective tyrosine kinase inhibition of insulin-like growth factor-1 receptor inhibits human and mouse breast cancer-induced bone cell activity, bone remodeling, and osteolysis.
    Authors: Logan J, Sophocleous A, Marino S, Muir M, Brunton V, Idris A
    J Bone Miner Res, 2013;28(5):1229-42.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  60. Role of IGF-1 pathway in lung fibroblast activation.
    Authors: Hung C, Rohani M, Lee S, Chen P, Schnapp L
    Respir Res, 2013;14(0):102.
    Species: Mouse
    Sample Type: Whole Cells
    Application: cell culture
  61. Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa.
    Authors: Tucker, Budd A, Mullins, Robert F, Streb, Luan M, Anfinson, Kristin, Eyestone, Mari E, Kaalberg, Emily, Riker, Megan J, Drack, Arlene V, Braun, Terry A, Stone, Edwin M
    Elife, 2013;2(0):e00824.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  62. Protein distribution during human erythroblast enucleation in vitro.
    Authors: Bell A, Satchwell T, Heesom K, Hawley B, Kupzig S, Hazell M, Mushens R, Herman A, Toye A
    PLoS ONE, 2013;8(4):e60300.
    Species: Human
    Sample Type: Whole Cells
    Application: cell culture
  63. Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation.
    Authors: Wolf A, Rietscher K, Glass M, Huttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M
    J Cell Sci, 2013;126(0):1832-44.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  64. Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c.
    Authors: Di Maggio N, Mehrkens A, Papadimitropoulos A, Schaeren S, Heberer M, Banfi A, Martin I
    Stem Cells, 2012;30(7):1455-64.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  65. Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells.
    Authors: Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L
    Cell Transplant, 2012;21(6):1321-39.
    Species: Human
    Sample Type: Whole Cells
    Application: cell culture
  66. The hedgehog system in ovarian follicles of cattle selected for twin ovulations and births: evidence of a link between the IGF and hedgehog systems.
    Authors: Aad, Pauline, Echternkamp, Sherrill, Sypherd, David D, Schreiber, Nicole B, Spicer, Leon J
    Biol Reprod, 2012;87(4):79.
    Species: Bovine
    Sample Type: Whole Cells
    Application: Bioassay
  67. The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1.
    Authors: Zelinka C, Scott M, Volkov L, Fischer A
    PLoS ONE, 2012;7(9):e44477.
    Species: Chicken
    Sample Type: In Vivo
    Application: In Vivo
  68. IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase.
    Authors: Laranjeira AB, de Vasconcellos JF, Sodek L, Spago MC, Fornazim MC, Tone LG, Brandalise SR, Nowill AE, Yunes JA
    Leukemia, 2011;26(5):1001-11.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  69. Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling.
    Authors: Iozzo RV, Buraschi S, Genua M
    J. Biol. Chem., 2011;286(40):34712-21.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  70. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
    Authors: Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Jacoby JJ, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, Powis G
    Mol. Cancer Ther., 2010;9(3):706-17.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  71. A novel type of glial cell in the retina is stimulated by insulin-like growth factor 1 and may exacerbate damage to neurons and Muller glia.
    Authors: Fischer AJ, Scott MA, Zelinka C, Sherwood P
    Glia, 2010;58(6):633-49.
    Species: Chicken
    Sample Type: In Vivo
    Application: In Vivo
  72. Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas.
    Authors: Piao W, Wang Y, Adachi Y, Yamamoto H, Li R, Imsumran A, Li H, Maehata T, Ii M, Arimura Y, Lee CT, Shinomura Y, Carbone DP, Imai K
    Mol. Cancer Ther., 2008;7(6):1483-93.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  73. Regulation of bone morphogenetic protein signalling in human pulmonary vascular development.
    Authors: Southwood M, Jeffery TK, Yang X, Upton PD, Hall SM, Atkinson C, Haworth SG, Stewart S, Reynolds PN, Long L, Trembath RC, Morrell NW
    J. Pathol., 2008;214(1):85-95.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  74. Growth hormone promotes lymphangiogenesis.
    Authors: Banziger-Tobler NE, Halin C, Kajiya K, Detmar M
    Am. J. Pathol., 2008;173(2):586-97.
    Species: N/A
    Sample Type: N/A
    Application: WB Ctrl
  75. Development and validation of sandwich ELISA microarrays with minimal assay interference.
    Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
    J. Proteome Res., 2008;7(6):2406-14.
    Species: N/A
    Sample Type: N/A
    Application: ELISA Standard
  76. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
    Authors: Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L
    Cell Stem Cell, 2008;2(6):602-12.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  77. GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.
    Authors: Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y
    Mol. Biol. Cell, 2007;18(10):3764-75.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  78. Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor.
    Authors: Spicer LJ, Aad PY
    Biol. Reprod., 2007;77(1):18-27.
    Species: Bovine
    Sample Type: Whole Cells
    Application: Bioassay
  79. Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration.
    Authors: Li Y, Fan J, Chen M, Li W, Woodley DT
    J. Invest. Dermatol., 2006;126(9):2096-105.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  80. The effect of insulin-like growth factor-I on hepatocyte apoptosis after bile duct ligation in rat.
    Authors: Sheen-Chen SM, Ho HT, Chia-Pei L, Hung KS, Eng HL
    Dig. Dis. Sci., 2006;51(12):2220-4.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  81. Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells.
    Authors: Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB
    Glia, 2006;53(8):845-57.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  82. Increased extraocular muscle strength with direct injection of insulin-like growth factor-I.
    Authors: Anderson BC, Christiansen SP, Grandt S, Grange RW, McLoon LK
    Invest. Ophthalmol. Vis. Sci., 2006;47(6):2461-7.
    Species: Rabbit
    Sample Type: In Vivo
    Application: In Vivo
  83. Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium.
    Authors: Bartunek J, Croissant JD, Wijns W, Gofflot S, de Lavareille A, Vanderheyden M, Kaluzhny Y, Mazouz N, Willemsen P, Penicka M, Mathieu M, Homsy C, De Bruyne B, McEntee K, Lee IW, Heyndrickx GR
    Am. J. Physiol. Heart Circ. Physiol., 2006;292(2):H1095-104.
    Species: Canine
    Sample Type: Whole Cells
    Application: Bioassay
  84. Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice.
    Authors: Larsen PH, DaSilva AG, Conant K, Yong VW
    J. Neurosci., 2006;26(8):2207-14.
    Species: Mouse
    Sample Type: Whole Cells
    Application: Bioassay
  85. Growth differentiation factor-9 has divergent effects on proliferation and steroidogenesis of bovine granulosa cells.
    Authors: Spicer LJ, Aad PY, Allen D, Mazerbourg S, Hsueh AJ
    J. Endocrinol., 2006;189(2):329-39.
    Species: Bovine
    Sample Type: Whole Cells
    Application: Bioassay
  86. Growth hormone-induced stimulation of multilineage human hematopoiesis.
    Authors: Hanley MB, Napolitano LA, McCune JM
    Stem Cells, 2005;23(8):1170-9.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  87. Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing.
    Authors: Brenner N, Huning M, Stange R
    Calcif. Tissue Int., 2004;74(4):388-97.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  88. The effects of in ovo rhIGF-I administration on expression of the growth hormone secretagogue receptor (GHSR) during chicken embryonic development.
    Authors: Gahr SA, Kocamis H, Richter JJ, Killefer J
    Growth Dev Aging, 2004;68(1):3-10.
    Species: Chicken
    Sample Type: In Vivo
    Application: In Vivo
  89. Insulin growth factor-1 protects against excitotoxicity in the rat striatum.
    Authors: Escartin C, Boyer F, Bemelmans AP, Hantraye P, Brouillet E
    Neuroreport, 2004;15(14):2251-4.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  90. Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats.
    Authors: Wildemann B, Bamdad P, Holmer Ch, Haas NP, Raschke M, Schmidmaier G
    Bone, 2004;34(5):862-8.
    Species: Rat
    Sample Type: In Vivo
    Application: In Vivo
  91. Improvement of the developmental capacity of oocytes from prepubertal cattle by intraovarian insulin-like growth factor-I application.
    Authors: Oropeza A, Wrenzycki C, Herrmann D, Hadeler KG, Niemann H
    Biol. Reprod., 2004;70(6):1634-43.
    Species: Bovine
    Sample Type: In Vivo
    Application: In Vivo
  92. Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition.
    Authors: Studer RK, Bergman R, Stubbs T, Decker K
    Arthritis Res. Ther., 2004;6(1):R56-R64.
    Species: Rabbit
    Sample Type: Whole Cells
    Application: Bioassay
  93. Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1.
    Authors: Loeser RF, Carlson CS, Del Carlo M, Cole A
    Arthritis Rheum., 2002;46(9):2349-57.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Type: Whole Cells
    Application: Bioassay
  94. Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
    Authors: Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC
    Oncogene, 2002;21(37):5673-83.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
  95. Quantitative assessment of the integrity of the blood-retinal barrier in mice.
    Authors: Derevjanik NL, Vinores SA, Xiao WH, Mori K, Turon T, Hudish T, Dong S, Campochiaro PA
    Invest. Ophthalmol. Vis. Sci., 2002;43(7):2462-7.
    Species: Mouse
    Sample Type: In Vivo
    Application: In Vivo
  96. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease.
    Authors: Loeser RF, 2018, Shanker G, Carlson CS, Gardin JF, Shelton BJ, Sonntag WE
    Arthritis Rheum., 2000;43(9):2110-20.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Type: Whole Cells
    Application: Bioassay
  97. Immediate early gene expression in dog thyrocytes in response to growth, proliferation, and differentiation stimuli.
    Authors: Deleu S, Pirson I, Clermont F, Nakamura T, Dumont JE, Maenhaut C
    J. Cell. Physiol., 1999;181(2):342-54.
    Species: Canine
    Sample Type: Whole Cells
    Application: Bioassay
  98. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes.
    Authors: Nevin Z, Factor D, Karl R, Douvaras P, Laukka J, Windrem M, Goldman S, Fossati V, Hobson G, Tesar P
    Am J Hum Genet, 0;100(4):617-634.
    Species: Human
    Sample Type: Whole Cells
    Application: Bioassay
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Recombinant Human IGF-I, Animal-Free Protein

BA AFL291
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RB01
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