TGF-beta 1, 2, 3 Antibody Summary
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Applications
Human TGF-beta 1 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data

TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta 1, 2, 3 Antibody. Recombinant Human TGF-beta 1 (Catalog # 240-B) inhibits Recombinant Mouse IL-4 (Catalog # 404-ML) induced proliferation in the HT-2 mouse T cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Mouse IL-4 (7.5 ng/mL) activity elicited by Recombinant Human TGF-beta 1 (1 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-TGF-beta 1, 2, 3 Monoclonal Antibody (Catalog # MAB1835). The ND50 is typically 0.25-1.25 µg/mL.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TGF-beta 1, 2, 3
TGF-beta 1, -2, and -3 are a closely related group of proteins (70‑80% sequence homology) that are produced by many cell types and function as growth and differentiation factors. The active forms of TGF-beta 1, -2, and -3 are disulfide-linked homodimers.
- Ayala A. et al. (1992) FASEB J. 6:A1604.
- Roberts A.B. and Sporn M.B., eds. (1990) Peptide Growth Factors and Their Receptors I, Springer-Verlag, 419.
- Dasch J.R. et al. (1989) J. Immunol. 142:1536.
Product Datasheets
Citations for TGF-beta 1, 2, 3 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
154
Citations: Showing 1 - 10
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Twist-related protein 1 induces epithelial-mesenchymal transition and renal fibrosis through the upregulation of complement 3
Authors: T Otsuki, N Fukuda, L Chen, A Tsunemi, M Abe
PLoS ONE, 2022;17(8):e0272917.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity
Authors: J Hanna, F Beke, LM O'Brien, C Kapeni, HC Chen, V Carbonaro, AB Kim, K Kishore, TE Adolph, MO Skjoedt, K Skjoedt, M de la Roch, M de la Roch
Nature Communications, 2022;13(1):4075.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function
Authors: GN Yin, DK Kim, JI Kang, Y Im, DS Lee, AR Han, J Ock, MJ Choi, MH Kwon, A Limanjaya, SB Jung, J Yang, KW Min, J Yun, Y Koh, JE Park, D Hwang, JK Suh, JK Ryu, HM Kim
Experimental & Molecular Medicine, 2022;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration
Authors: KV Manian, CA Galloway, S Dalvi, AA Emanuel, JA Mereness, W Black, L Winschel, C Soto, Y Li, Y Song, W DeMaria, A Kumar, I Slukvin, MP Schwartz, WL Murphy, B Anand-Apte, M Chung, DSW Benoit, R Singh
Cell Stem Cell, 2021;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-&beta signaling
Authors: MR Patel, AM Weaver
Cell Reports, 2021;34(10):108829.
Species: Rat
Sample Types: Cell Lysates
Applications: Western Blot -
Methods to improve efficacy of orally administered bioactive peptides using bovine colostrum as an exemplar
Authors: RJ Playford, MJ Weiser, T Marchbank
PLoS ONE, 2021;16(6):e0253422.
Species: Bovine
Sample Types: Milk
Applications: ELISA Capture -
Splenectomy improves liver fibrosis via tumor necrosis factor superfamily 14 (LIGHT) through the JNK/TGF-&beta1 signaling pathway
Authors: QS Liang, JG Xie, C Yu, Z Feng, J Ma, Y Zhang, D Wang, J Lu, R Zhuang, J Yin
Experimental & Molecular Medicine, 2021;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Human Keratinocytes Inhibit CD4+ T-Cell Proliferation through TGFB1 Secretion and Surface Expression of HLA-G1 and PD-L1 Immune Checkpoints
Authors: G Mestrallet, F Auvré, C Schenowitz, ED Carosella, J LeMaoult, MT Martin, N Rouas-Frei, NO Fortunel
Cells, 2021;10(6):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis
Authors: D Basak, Z Jamal, A Ghosh, PK Mondal, P Dey Talukd, S Ghosh, B Ghosh Roy, R Ghosh, A Halder, A Chowdhury, GK Dhali, BK Chattopadh, ML Saha, A Basu, S Roy, C Mukherjee, NK Biswas, U Chatterji, S Datta
PLoS ONE, 2021;16(8):e0255915.
Species: Human
Sample Types: Tissue Homogenates
Applications: Co-IP -
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
Authors: LF Campesato, S Budhu, J Tchaicha, CH Weng, M Gigoux, IJ Cohen, D Redmond, L Mangarin, S Pourpe, C Liu, R Zappasodi, D Zamarin, J Cavanaugh, AC Castro, MG Manfredi, K McGovern, T Merghoub, JD Wolchok
Nat Commun, 2020;11(1):4011.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
RAC1B Regulation of TGFB1 Reveals an Unexpected Role of Autocrine TGF&beta1 in the Suppression of Cell Motility
Authors: H Ungefroren, H Otterbein, UF Wellner, T Keck, H Lehnert, JU Marquardt
Cancers, 2020;12(12):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Variations in Circulating Active MMP-9 Levels During Renal Replacement Therapy
Authors: E Rodríguez-, JA Navarro-Ga, J Aceves-Rip, J Abarca-Zab, A Susmozas-S, T Bada-Bosch, E Hernández, E Mérida-Her, A Andrés, M Praga, M Fernández-, JM Aguado, J Segura, LM Ruilope, G Ruiz-Hurta
Biomolecules, 2020;10(4):.
Species: Human
Sample Types: Plasma
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Age-induced accumulation of methylmalonic acid promotes tumour progression
Authors: AP Gomes, D Ilter, V Low, JE Endress, J Fernández-, A Rosenzweig, T Schild, D Broekaert, A Ahmed, M Planque, I Elia, J Han, C Kinzig, E Mullarky, AP Mutvei, J Asara, R de Cabo, LC Cantley, N Dephoure, SM Fendt, J Blenis
Nature, 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis
Authors: Y Takagaki, SM Lee, Z Dongqing, M Kitada, K Kanasaki, D Koya
Autophagy, 2020;0(0):1-10.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Age-induced accumulation of methylmalonic acid promotes tumour progression
Authors: AP Gomes, D Ilter, V Low, JE Endress, J Fernández-, A Rosenzweig, T Schild, D Broekaert, A Ahmed, M Planque, I Elia, J Han, C Kinzig, E Mullarky, AP Mutvei, J Asara, R de Cabo, LC Cantley, N Dephoure, SM Fendt, J Blenis
Nature, 2020;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Anti-TGF-&beta attenuates tumor growth via polarization of tumor associated neutrophils towards an anti-tumor phenotype in colorectal cancer
Authors: F Qin, X Liu, J Chen, S Huang, W Wei, Y Zou, X Liu, K Deng, S Mo, J Chen, X Chen, Y Huang, W Liang
J Cancer, 2020;11(9):2580-2592.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice
Authors: W Li, AS Elshikha, C Cornaby, X Teng, G Abboud, J Brown, X Zou, L Zeumer-Spa, B Robusto, SC Choi, K Fredenburg, A Major, L Morel
JCI Insight, 2020;5(11):.
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TGF&beta-mediated expression of TGF&beta-activating integrins in SSc monocytes: disturbed activation of latent TGF&beta?
Authors: A van Caam, J Aarts, T van Ee, E Vitters, M Koenders, F van de Loo, P van Lent, F van den Ho, R Thurlings, MC Vonk, PM van der Kr
Arthritis Res. Ther., 2020;22(1):42.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
Authors: LF Campesato, S Budhu, J Tchaicha, CH Weng, M Gigoux, IJ Cohen, D Redmond, L Mangarin, S Pourpe, C Liu, R Zappasodi, D Zamarin, J Cavanaugh, AC Castro, MG Manfredi, K McGovern, T Merghoub, JD Wolchok
Nat Commun, 2020;11(1):4011.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Deficiency in Dipeptidyl Peptidase-4 Promotes Chemoresistance through the CXCL12/CXCR4/mTOR/TGF&beta Signaling Pathway in Breast Cancer Cells
Authors: S Li, Y Fan, A Kumagai, E Kawakita, M Kitada, K Kanasaki, D Koya
Int J Mol Sci, 2020;21(3):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
BMPR2 acts as a�gatekeeper to protect endothelial cells from increased TGF&beta�responses and altered cell mechanics
Authors: C Hiepen, J Jatzlau, S Hildebrand, B Kampfrath, M Goktas, A Murgai, JL Cuellar Ca, R Haag, C Ruppert, G Sengle, EA Cavalcanti, KG Blank, P Knaus
PLoS Biol., 2019;17(12):e3000557.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells
Authors: MR Shokri, M Bozorgmehr, A Ghanavatin, R Falak, M Aleahmad, S Kazemnejad, F Shokri, AH Zarnani
Sci Rep, 2019;9(1):10007.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TGF??1 upregulates the expression of lncRNA?ATB to promote atherosclerosis
Authors: H Yu, S Ma, L Sun, J Gao, C Zhao
Mol Med Rep, 2019;19(5):4222-4228.
Species: Human
Sample Types: Serum
Applications: ELISA Development (Capture) -
Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF??
Authors: B Liu, L Xu, X Yu, W Li, X Sun, S Xiao, M Guo, H Wang
Mol Med Rep, 2018;18(2):1987-1994.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Connective tissue growth factor expression after angiotensin II exposure is dependent on transforming growth factor-? signaling via the canonical Smad-dependent pathway in hypertensive induced myocardial fibrosis
Authors: CKS Wong, A Falkenham, T Myers, JF Légaré
J Renin Angiotensin Aldosterone Syst, 2018;19(1):1470320318759.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Proteomic Analysis of Nucleus Pulposus Cell-derived Extracellular Matrix Niche and Its Effect on Phenotypic Alteration of Dermal Fibroblasts
Authors: M Yuan, PJ Pai, X Liu, H Lam, BP Chan
Sci Rep, 2018;8(1):1512.
Species: Rabbit
Sample Types: Whole Cells
Applications: ICC -
Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells
Authors: M Idelson, R Alper, A Obolensky, N Yachimovic, J Rachmilewi, A Ejzenberg, E Beider, E Banin, B Reubinoff
Stem Cell Reports, 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
BMSCs pre-treatment ameliorates inflammation-related tissue destruction in LPS-induced rat DIC model
Authors: B Wang, S Wu, Z Ma, T Wang, C Yang
Cell Death Dis, 2018;9(10):1024.
Species: Rat
Sample Types: Whole Cells
Applications: Neutralization -
CD8+ T cells with high TGF??1 expression cause lymph node fibrosis following HIV infection
Authors: L Huang, J Deng, W Xu, H Wang, L Shi, F Wu, D Wu, W Nei, M Zhao, P Mao, X Zhou
Mol Med Rep, 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Agonist Activity -
Downregulation of membrane trafficking proteins and lactate conditioning determine loss of dendritic cell function in lung cancer
Authors: N Caronni, F Simoncello, F Stafetta, C Guarnaccia, JS Ruiz-Moren, B Opitz, T Galli, V Proux-Gill, F Benvenuti
Cancer Res., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a
Authors: S Tiwary, JE Morales, SC Kwiatkowsk, FF Lang, G Rao, JH McCarty
Sci Rep, 2018;8(1):8267.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
TGF-?1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA
Authors: T Shindo, S Doi, A Nakashima, K Sasaki, K Arihiro, T Masaki
Sci Rep, 2018;8(1):14060.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Bacterially activated B-cells drive T cell differentiation towards Tr1 through PD-1/PD-L1 expression
Authors: SS Said, GT Barut, N Mansur, A Korkmaz, A Sayi-Yazga
Mol. Immunol., 2018;96(0):48-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF??.
Authors: Bing Liu, Lili Xu, Xinming Yu, Wei Li, Xiaozhi Sun, Shun Xiao, Mingjin Guo, Haofu Wang
Molecular Medicine Reports, 2018;0(0):1791-3004.
Species: Human
Sample Types: Cell Lysate
Applications: Western Blot -
RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis
Authors: JR Cortes, A Ambesi-Imp, L Couronné, SA Quinn, CS Kim, AC da Silva A, Z West, L Belver, MS Martin, L Scourzic, G Bhagat, OA Bernard, AA Ferrando, T Palomero
Cancer Cell, 2018;33(2):259-273.e7.
Species: Mouse
Sample Types: Whole Cells
Applications: Activation -
TGF-?1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells
Authors: X Wang, F Dong, S Zhang, W Yang, W Yu, Z Wang, S Zhang, J Wang, S Ma, P Wu, Y Gao, J Dong, F Tang, T Cheng, H Ema
Stem Cell Reports, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function
Authors: RM Petri, A Hackel, K Hahnel, CA Dumitru, K Bruderek, SB Flohe, A Paschen, S Lang, S Brandau
Stem Cell Reports, 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study
Authors: K Brekke, M Sommerfelt, M Ökvist, AM Dyrhol-Rii, D Kvale
BMC Infect. Dis, 2017;17(1):228.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Granulocytic myeloid derived suppressor cells from human cord blood modulate T-helper-cell response towards an anti-inflammatory phenotype
Authors: N Köstlin, M Vogelmann, B Spring, J Schwarz, J Feucht, C Härtel, TW Orlikowsky, CF Poets, C Gille
Immunology, 2017;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Mechanosignaling activation of TGF? maintains intervertebral disc homeostasis
Authors: Q Bian, L Ma, A Jain, JL Crane, K Kebaish, M Wan, Z Zhang, X Edward Guo, PD Sponseller, CA Séguin, LH Riley, Y Wang, X Cao
Bone Res, 2017;5(0):17008.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
TGF-? signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes
Authors: S Khakipoor, C Ophoven, M Schrödl-Hä, M Feuerstein, B Heimrich, JW Deitmer, E Roussa
Glia, 2017;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: Neutralization -
ALS skeletal muscle shows enhanced TGF-? signaling, fibrosis and induction of fibro/adipogenic progenitor markers
Authors: D Gonzalez, O Contreras, DL Rebolledo, JP Espinoza, B van Zunder, E Brandan
PLoS ONE, 2017;12(5):e0177649.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Histone Deacetylase (HDAC) Inhibition Induces I?B Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells
Authors: HR Gatla, Y Zou, MM Uddin, B Singha, P Bu, A Vancura, I Vancurova
J. Biol. Chem., 2017;292(12):5043-5054.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3(+) regulatory T cells
Authors: M Pasztoi, J Pezoldt, M Beckstette, C Lipps, D Wirth, M Rohde, K Paloczi, EI Buzas, J Huehn
Eur. J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures
Authors: CJ Bohlen, FC Bennett, AF Tucker, HY Collins, SB Mulinyawe, BA Barres
Neuron, 2017;94(4):759-773.e8.
Species: Rat
Sample Types: Whole Cells
Applications: Neutralization -
A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw
Authors: DJ Urban, N Anthwal, ZX Luo, JA Maier, A Sadier, AS Tucker, KE Sears
Proc. Biol. Sci, 2017;284(1848):.
Species: Opossum
Sample Types: In Vivo
Applications: In Vivo -
Integrin ?1 activation induces an anti-melanoma host response
Authors: L Ritsma, I Dey-Guha, N Talele, X Sole, Salony, J Chowdhury, KN Ross, S Ramaswamy
PLoS ONE, 2017;12(4):e0175300.
Species: Human
Sample Types: Whole Cells
Applications: Functional Assay -
TGF-?1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT)
PLoS ONE, 2016;11(9):e0162221.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs
Nature, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
[64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma
Authors: I Minn, SM Koo, HS Lee, M Brummet, SP Rowe, MA Gorin, P Sysa-Shah, WD Lewis, HH Ahn, Y Wang, SR Banerjee, RC Mease, S Nimmagadda, ME Allaf, MG Pomper, X Yang
Oncotarget, 2016;7(35):56471-56479.
Species: Mink
Sample Types: Whole Cells
Applications: Neutralization -
Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion
PLoS ONE, 2016;11(11):e0166500.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury
Authors: Jeremy S Duffield
J. Clin. Invest., 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Sterile Inflammation Enhances ECM Degradation in Integrin ?1 KO Embryonic Skin
Cell Rep, 2016;16(12):3334-47.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-? signalling
Authors: Fatemeh Mirzamoham
Nat Commun, 2016;7(0):12047.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Mammary epithelial cell phagocytosis downstream of TGF-beta3 is characterized by adherens junction reorganization.
Authors: Fornetti J, Flanders K, Henson P, Tan A, Borges V, Schedin P
Cell Death Differ, 2016;23(2):185-96.
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western Blot -
Kluyveromyces marxianus and Saccharomyces boulardii Induce Distinct Levels of Dendritic Cell Cytokine Secretion and Significantly Different T Cell Responses In Vitro
PLoS ONE, 2016;11(11):e0167410.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes
Stem Cell Reports, 2016;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
K+/Cl- cotransporter KCC2 membrane trafficking and functionality is regulated by transforming growth factor beta 2
J Cell Sci, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development
Authors: H Nagashima, Y Okuyama, T Hayashi, N Ishii, T So
J Immunol, 2016;0(0):.
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Cancer associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-�-dependent pathways in genotype-specific oral cancer
Authors: S S Prime
Carcinogenesis, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Neutralization -
Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy
Arthritis Res Ther, 2016;18(1):184.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
TGF-? Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions
Authors: X Chen, DL Rateri, DA Howatt, A Balakrishn, JJ Moorleghen, LA Cassis, A Daugherty
PLoS ONE, 2016;11(4):e0153811.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.
Authors: Rossetti M, Spreafico R, Saidin S, Chua C, Moshref M, Leong J, Tan Y, Thumboo J, van Loosdregt J, Albani S
J Immunol, 2015;194(1):113-24.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-beta (TGF-beta) Activation and Fibroblast Differentiation.
Authors: Dayer C, Stamenkovic I
J Biol Chem, 2015;290(22):13763-78.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-beta.
Authors: Ungefroren H, Hyder A, Hinz H, Groth S, Lange H, El-Sayed K, Ehnert S, Nussler A, Fandrich F, Gieseler F
PLoS ONE, 2015;10(2):e0118097.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Bortezomib inhibits expression of TGF-beta1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells.
Authors: Chang T, Poltoratsky V, Vancurova I
J Immunol, 2015;194(6):2942-53.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition.
Authors: Mizuuchi Y, Aishima S, Ohuchida K, Shindo K, Fujino M, Hattori M, Miyazaki T, Mizumoto K, Tanaka M, Oda Y
Lab Invest, 2015;95(2):193-206.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
IL-10 inhibits neuraminidase-activated TGF-beta and facilitates Th1 phenotype during early phase of infection.
Authors: Dutta A, Huang C, Chen T, Lin C, Chiu C, Lin Y, Chang C, He Y
Nat Commun, 2015;6(0):6374.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-beta Signaling in the Retinal Pigment Epithelium.
Authors: Li Y, Song D, Song Y, Zhao L, Wolkow N, Tobias J, Song W, Dunaief J
J Biol Chem, 2015;290(19):11918-34.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-beta.
Authors: Pieters B, Arntz O, Bennink M, Broeren M, van Caam A, Koenders M, van Lent P, van den Berg W, de Vries M, van der Kraan P, van de Loo F
PLoS ONE, 2015;10(3):e0121123.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
STAT3 governs hyporesponsiveness and granzyme B-dependent suppressive capacity in human CD4+ T cells.
Authors: Schmetterer K, Neunkirchner A, Wojta-Stremayr D, Leitner J, Steinberger P, Pickl W
FASEB J, 2015;29(3):759-71.
Species: Human
Sample Types: Whole Cells
Applications: Blocking -
Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity.
Authors: Carrillo-Galvez A, Cobo M, Cuevas-Ocana S, Gutierrez-Guerrero A, Sanchez-Gilabert A, Bongarzone P, Garcia-Perez A, Munoz P, Benabdellah K, Toscano M, Martin F, Anderson P
Stem Cells, 2015;33(1):183-95.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
STAT6-Dependent Collagen Synthesis in Human Fibroblasts Is Induced by Bovine Milk.
Authors: Kippenberger S, Zoller N, Kleemann J, Muller J, Kaufmann R, Hofmann M, Bernd A, Meissner M, Valesky E
PLoS ONE, 2015;10(7):e0131783.
Species: Bovine
Sample Types: Milk
Applications: Neutralization -
The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-beta.
Authors: Craft C, Pietka T, Schappe T, Coleman T, Combs M, Klein S, Abumrad N, Mecham R
Diabetes, 2014;63(6):1920-32.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Angiotensin II-dependent TGF-beta signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
Authors: Gallo E, Loch D, Habashi J, Calderon J, Chen Y, Bedja D, van Erp C, Gerber E, Parker S, Sauls K, Judge D, Cooke S, Lindsay M, Rouf R, Myers L, ap Rhys C, Kent K, Norris R, Huso D, Dietz H
J Clin Invest, 2014;124(1):448-60.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion.
Authors: Hassona Y, Cirillo N, Heesom K, Parkinson E, Prime S
Br J Cancer, 2014;111(6):1230-7.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Neutralization -
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Authors: Nagashima, Hiroyuki, Okuyama, Yuko, Asao, Atsuko, Kawabe, Takeshi, Yamaki, Satoshi, Nakano, Hiroyasu, Croft, Michael, Ishii, Naoto, So, Takanori
Nat Immunol, 2014;15(5):449-56.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Biglycan and decorin differentially regulate signaling in the fetal membranes.
Authors: Wu Z, Horgan C, Carr O, Owens R, Iozzo R, Lechner B
Matrix Biol, 2014;35(0):266-75.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1epsilon transgenic mice.
Authors: Lin Z, Wang C, Xia H, Liu W, Xiao W, Qian L, Jia X, Ding Y, Ji M, Gong W
Immunology, 2014;141(3):401-15.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation.
Authors: Faustino L, Fonseca D, Florsheim E, Resende R, Lepique A, Faquim-Mauro E, Gomes E, Silva J, Yagita H, Russo M
Mucosal Immunol, 2014;7(5):1199-208.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vdelta 2 T lymphocytes in non-Hodgkin lymphomas.
Authors: Musso A, Catellani S, Canevali P, Tavella S, Vene R, Boero S, Pierri I, Gobbi M, Kunkl A, Ravetti J, Zocchi M, Poggi A
Haematologica, 2014;99(1):131-9.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Bovine gammadelta T cells are a major regulatory T cell subset.
Authors: Guzman E, Hope J, Taylor G, Smith A, Cubillos-Zapata C, Charleston B
J Immunol, 2014;193(1):208-22.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay -
Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-beta.
Authors: Alcaraz L, Exposito J, Chuvin N, Pommier R, Cluzel C, Martel S, Sentis S, Bartholin L, Lethias C, Valcourt U
J Cell Biol, 2014;205(3):409-28.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Basal localization of MT1-MMP is essential for epithelial cell morphogenesis in 3D collagen matrix.
Authors: Weaver S, Wolters B, Ito N, Woskowicz A, Kaneko K, Shitomi Y, Seiki M, Itoh Y
J Cell Sci, 2014;127(0):1203-13.
Species: Canine
Sample Types: Whole Cells
Applications: Neutralization -
Influenza promotes collagen deposition via alphavbeta6 integrin-mediated transforming growth factor beta activation.
Authors: Jolly L, Stavrou A, Vanderstoken G, Meliopoulos V, Habgood A, Tatler A, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli M, Schultz-Cherry S, Jenkins G
J Biol Chem, 2014;289(51):35246-63.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome.
Authors: Cook J, Carta L, Benard L, Chemaly E, Chiu E, Rao S, Hampton T, Yurchenco P, Costa K, Hajjar R, Ramirez F
J Clin Invest, 2014;124(3):1329-39.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Functional effects of TGF-beta1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma.
Authors: Gao P, Zhou Y, Xian L, Li C, Xu T, Plunkett B, Huang S, Wan M, Cao X
J Immunol, 2014;192(10):4560-70.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity.
Authors: Norris B, Uebelhoer L, Nakaya H, Price A, Grakoui A, Pulendran B
Immunity, 2013;38(2):309-21.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress.
Authors: Gandhi N, Su Z, Zhang X, Volpe E, Pelegrino F, Rahman S, Li D, Pflugfelder S, de Paiva C
J Leukoc Biol, 2013;94(6):1293-301.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-beta.
Authors: Yu C, Becker C, Wang Y, Marches F, Helft J, Leboeuf M, Anguiano E, Pourpe S, Goller K, Pascual V, Banchereau J, Merad M, Palucka K
Immunity, 2013;38(4):818-30.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
The metalloprotease ADAM12 regulates the effector function of human Th17 cells.
Authors: Zhou A, El Hed A, Mercer F, Kozhaya L, Unutmaz D
PLoS ONE, 2013;8(11):e81146.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Peyer's patch inducer cells play a leading role in the formation of B and T cell zone architecture.
Authors: Nakagawa R, Togawa A, Nagasawa T, Nishikawa S
J Immunol, 2013;190(7):3309-18.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.
Authors: Guo Z, Khattar M, Schroder P, Miyahara Y, Wang G, He X, Chen W, Stepkowski S
J Immunol, 2013;190(7):3153-62.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement.
Authors: Bialas A, Stevens B
Nat Neurosci, 2013;16(12):1773-82.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Immunodepletion -
Staphylococcus aureus phenol-soluble modulin peptides modulate dendritic cell functions and increase in vitro priming of regulatory T cells.
Authors: Schreiner J, Kretschmer D, Klenk J, Otto M, Buhring H, Stevanovic S, Wang J, Beer-Hammer S, Peschel A, Autenrieth S
J Immunol, 2013;190(7):3417-26.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
CD2-mediated regulation of peripheral CD4(+) CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim.
Authors: Kashiwakura Y, Sakurai D, Kanno Y, Hashiguchi M, Kobayashi A, Kurosu A, Tokudome S, Kobata T, Kojima H
Immunology, 2013;139(1):48-60.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta.
Authors: Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F
Nature, 2012;484(7395):514-8.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
TGF-beta signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
Authors: Zhang N, Bevan MJ
Nat. Immunol., 2012;13(7):667-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance.
Authors: Chaturvedi V, Collison LW, Guy CS, Workman CJ, Vignali DA
J. Immunol., 2011;186(12):6661-6.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease.
Authors: Ma W, Han W, Greer PA, Tuder RM, Toque HA, Wang KK, Caldwell RW, Su Y
J. Clin. Invest., 2011;121(11):4548-66.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets.
Authors: Montane J, Bischoff L, Soukhatcheva G, Dai DL, Hardenberg G, Levings MK, Orban PC, Kieffer TJ, Tan R, Verchere CB
J. Clin. Invest., 2011;121(0):3024.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.
Authors: Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ
Mol. Biol. Cell, 2011;22(10):1686-98.
Species: Canine
Sample Types: Whole Cells
Applications: Neutralization -
Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade.
Authors: Lu H, Wagner WM, Gad E, Yang Y, Duan H, Amon LM, Van Denend N, Larson ER, Chang A, Tufvesson H, Disis ML
J. Immunol., 2010;184(9):5360-7.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1.
Authors: Linke A, Goren I, Bosl MR, Pfeilschifter J, Frank S
J. Invest. Dermatol., 2010;130(3):866-75.
Species: Mouse
Sample Types: Cell Lysates
Applications: Bioassay -
Anti-Asthma Simplified Herbal Medicine Intervention-induced long-lasting tolerance to allergen exposure in an asthma model is interferon-gamma, but not transforming growth factor-beta dependent.
Authors: Srivastava K, Zhang T, Yang N, Sampson H, Li XM
Clin. Exp. Allergy, 2010;40(11):1678-88.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior.
Authors: Koo JW, Russo SJ, Ferguson D, Nestler EJ, Duman RS
Proc. Natl. Acad. Sci. U.S.A., 2010;107(6):2669-74.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells.
Authors: Tso GH, Law HK, Tu W
Stem Cells, 2010;28(5):939-54.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta.
Authors: Han G, Wang R, Chen G
Immunology, 2010;129(2):197-206.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.
Authors: Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M
Eur. J. Immunol., 2009;39(5):1221-30.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.
Authors: Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA
Nat. Immunol., 2009;10(9):981-91.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
The AP-1 transcription factor Batf controls T(H)17 differentiation.
Authors: Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM
Nature, 2009;460(7253):405-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1.
Authors: Han Y, Guo Q, Zhang M, Chen Z, Cao X
J. Immunol., 2009;182(1):111-20.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Loss of Thy-1 inhibits alveolar development in the newborn mouse lung.
Authors: Nicola T, Hagood JS, James ML, Macewen MW, Williams TA, Hewitt MM, Schwiebert L, Bulger A, Oparil S, Chen YF, Ambalavanan N
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(5):L738-50.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function.
Authors: Tran DQ, Glass DD, Uzel G, Darnell DA, Spalding C, Holland SM, Shevach EM
J. Immunol., 2009;182(5):2929-38.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Fractional CO2 laser: a novel therapeutic device upon photobiomodulation of tissue remodeling and cytokine pathway of tissue repair.
Authors: Prignano F, Campolmi P, Bonan P
Dermatol Ther, 2009;22(0):S8-15.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling.
Authors: Pen A, Moreno MJ, Durocher Y, Deb-Rinker P, Stanimirovic DB
Oncogene, 2008;27(54):6834-44.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Molecular mechanisms of TGFbeta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506.
Authors: Akool el-S, Doller A, Babelova A, Tsalastra W, Moreth K, Schaefer L, Pfeilschifter J, Eberhardt W
J. Immunol., 2008;181(4):2831-45.
Species: Rat
Sample Types: In Vivo
Applications: Neutralization -
CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells.
Authors: Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, Chen W
Nat. Med., 2008;14(5):528-35.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.
Authors: Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L
Am. J. Pathol., 2008;172(4):1127-40.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Characterization of naturally occurring CD4+CD25+ regulatory T cells in rhesus monkeys.
Authors: Haanstra KG, van der Maas MJ, 't Hart BA, Jonker M
Transplantation, 2008;85(8):1185-92.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Neutralization -
Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.
Authors: Carlson ME, Hsu M, Conboy IM
Nature, 2008;454(7203):528-32.
Species: Mouse
Sample Types: Whole Tissue
Applications: Neutralization -
Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells.
Authors: van der Vliet HJ, Wang R, Yue SC, Koon HB, Balk SP, Exley MA
J. Immunol., 2008;180(11):7287-93.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells.
Authors: Terme M, Chaput N, Combadiere B, Ma A, Ohteki T, Zitvogel L
J. Immunol., 2008;180(7):4679-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge.
Authors: He R, Oyoshi MK, Jin H, Geha RS
Proc. Natl. Acad. Sci. U.S.A., 2007;104(40):15817-22.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses.
Authors: Alatrakchi N, Graham CS, van der Vliet HJ, Sherman KE, Exley MA, Koziel MJ
J. Virol., 2007;81(11):5882-92.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
In vitro induction of mucosa-type dendritic cells by all-trans retinoic acid.
Authors: Saurer L, McCullough KC, Summerfield A
J. Immunol., 2007;179(6):3504-14.
Species: Porcine
Sample Types: Cell Culture Supernates
Applications: ELISA Development -
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
Blood, 2007;109(10):4272-9.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Luminex Development -
Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes.
Authors: Lamar JM, Iyer V, DiPersio CM
J. Invest. Dermatol., 2007;128(3):575-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction.
Authors: Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S
Gut, 2006;56(2):243-52.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.
Authors: Neurohr C, Nishimura SL, Sheppard D
Am. J. Respir. Cell Mol. Biol., 2006;35(2):252-9.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells.
Authors: Rosendahl AH, Forsberg G
Kidney Int., 2006;70(9):1584-90.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct.
Authors: Maeshima A, Vaughn DA, Choi Y, Nigam SK
Dev. Biol., 2006;295(2):473-85.
Species: Rat
Sample Types: Whole Tissue
Applications: Neutralization -
Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes.
Authors: Koelle DM, Huang J, Hensel MT, McClurkan CL
J. Virol., 2006;80(6):2863-72.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cells.
Authors: Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW, Chatterjee SK
J. Cell. Biochem., 2006;97(5):1036-51.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Requirement of Smad3 for mast cell growth.
Authors: Funaba M, Nakaya K, Ikeda T, Murakami M, Tsuchida K, Sugino H
Cell. Immunol., 2006;240(1):47-52.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Transforming growth factor beta1 regulates follistatin mRNA expression during in vitro bovine granulosa cell differentiation.
Authors: Fazzini M, Vallejo G, Colman-Lerner A, Trigo R, Campo S, Baranao JL, Saragueta PE
J. Cell. Physiol., 2006;207(1):40-8.
Species: Bovine
Sample Types: Whole Cells
Applications: Neutralization -
Long-term staphylococcal enterotoxin C1 exposure induces soluble factor-mediated immunosuppression by bovine CD4+ and CD8+ T cells.
Authors: Seo KS, Lee SU, Park YH, Davis WC, Fox LK, Bohach GA
Infect. Immun., 2006;75(1):260-9.
Species: Bovine
Sample Types: Whole Cells
Applications: Neutralization -
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
Authors: Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB
Blood, 2005;105(2):750-8.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Neutralization -
Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta.
Authors: Huang X, Zhu J, Yang Y
J. Immunol., 2005;175(7):4283-91.
Species: Mouse
Sample Types:
Applications: Neutralization -
Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF beta signaling.
Authors: Close JL, Gumuscu B, Reh TA
Development, 2005;132(13):3015-26.
Species: Rat
Sample Types: In Vivo
Applications: Neutralization -
P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2.
Authors: Paliwal S, Shi J, Dhru U, Zhou Y, Schuger L
Biochem. Biophys. Res. Commun., 2004;315(4):1104-9.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates.
Authors: Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ
J. Immunol., 2004;172(9):5753-64.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Tissue Homogenates
Applications: Western Blot -
TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.
Authors: Kitani A, Fuss I, Pedersen A, Nawata H
J. Immunol., 2004;172(2):834-42.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures.
Authors: Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, Blazar BR, Porter SB
Blood, 2004;104(2):453-61.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells.
Authors: Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, Qiuping Z, Junyan L, Zhang X, Jinquan T
Immunology, 2004;112(2):274-89.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression.
Authors: Koenen HJ, Fasse E, Joosten I
J. Immunol., 2003;171(12):6431-41.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Immunosuppression in hamsters with progressive visceral leishmaniasis is associated with an impairment of protein kinase C activity in their lymphocytes that can be partially reversed by okadaic acid or anti-transforming growth factor beta antibody.
Authors: Mookerjee A, Sen PC, Ghose AC
Infect. Immun., 2003;71(5):2439-46.
Species: Hamster
Sample Types: Whole Cells
Applications: Neutralization -
Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice.
Authors: Kobayashi T, Iijima K, Kita H
J. Immunol., 2003;170(11):5756-63.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.
Authors: Chen, WanJun, Jin, Wenwen, Hardegen, Neil, Lei, Ke-Jian, Li, Li, Marinos, Nancy, McGrady, George, Wahl, Sharon M
J Exp Med, 2003;198(12):1875-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Neutralization -
The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure.
Authors: Feugate JE, 2019, Li Q, Wong L, Martins-Green M
e0216795, 2002;156(1):161-72.
Species: Chicken
Sample Types: Whole Cells
Applications: Neutralization -
Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-beta Signaling.
Authors: Carthy J, Engstrom U, Heldin C, Moustakas A
J Cell Biochem, 0;117(4):938-45.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta.
Authors: Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J
Immunol Cell Biol, 0;94(8):747-62.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
A mechanism linking Id2-TGFbeta crosstalk to reversible adaptive plasticity in neuroblastoma.
Authors: Chakrabarti L, Wang B, Lee N, Sandler A
PLoS ONE, 0;8(12):e83521.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western Blot -
PARP-1 regulates expression of TGF-beta receptors in T cells.
Authors: Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, Konkel J, Maruyama T, Wei G, Abbatiello B, Wang Z, Zhao K, Chen W
Blood, 0;122(13):2224-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
FAQs
-
Can the TGF-beta 1, 2, 3 Antibody, Cat# MAB1835, neutralize the activity of all three TGF-beta proteins?
Yes, this antibody can neutralize the activity of TGF-beta 1, 2, and 3 proteins.
Isotype Controls
Primary Antibodies
Reconstitution Buffers
Secondary Antibodies
Reviews for TGF-beta 1, 2, 3 Antibody
Average Rating: 4.4 (Based on 12 Reviews)
Have you used TGF-beta 1, 2, 3 Antibody?
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