TGF-beta 1, 2, 3 Antibody

Catalog # Availability Size / Price Qty
MAB1835-SP
MAB1835-100
MAB1835-500
TGF‑ beta  in PC-3 Human Cell Line.
3 Images
Product Details
Citations (129)
FAQs
Supplemental Products
Reviews (7)

TGF-beta 1, 2, 3 Antibody Summary

Specificity
Detects bovine, chicken, mouse, and human TGF-beta in ELISAs and Western blots. It recognizes human TGF-beta 1, TGF-beta 2, and TGF-beta 3.
Source
Monoclonal Mouse IgG1 Clone # 1D11
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Bovine bone-derived TGF-beta 1 and TGF-beta 2
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human TGF-beta 1 (Catalog # 240-B) under non-reducing conditions only
Immunohistochemistry
8-25 µg/mL
See below
Immunocytochemistry
8-25 µg/mL
See below

Human TGF-beta 1 Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: TGF‑ beta 1 Biotinylated Antibody (Catalog # BAF240)

Standard: Recombinant Human TGF-beta 1 Protein (Catalog # 240-B)

Neutralization
Measured by its ability to neutralize TGF‑ beta 1 inhibition of IL‑4-dependent proliferation in the HT‑2 mouse T cell line. Tsang, M. et al. (1990) Lymphokine Res. 9:607. The Neutralization Dose (ND50) is typically 0.25-1.25 µg/mL in the presence of 1 ng/mL Recombinant Human TGF‑ beta 1 and 7.5 ng/mL Recombinant Mouse IL‑4.
Binding Inhibition
Dasch, J.R. et al. (1994) J. Immunol. 142:1536.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Examples

Immunocytochemistry TGF‑ beta  in PC-3 Human Cell Line. View Larger

TGF‑ beta in PC-3 Human Cell Line. TGF‑ beta 1, 2, 3 was detected in immersion fixed PC-3 human prostate cancer cell line using 10 µg/mL Mouse Anti-TGF‑ beta 1, 2, 3 Monoclonal Antibody (Catalog # MAB1835) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunohistochemistry TGF-beta  in Human Skin. View Larger

TGF-beta in Human Skin. TGF-beta 1, 2, 3 was detected in immersion fixed paraffin-embedded human skin using 25 µg/mL Mouse
Anti-TGF-beta 1, 2, 3 Monoclonal Antibody (Catalog # MAB1835) overnight at 4 °C. Tissues was stained using the Anti-Mouse HRP-DAB Cell and Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with Haematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Neutralization TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta 1, 2, 3 Antibody. View Larger

TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta 1, 2, 3 Antibody. Recombinant Human TGF‑ beta 1 (Catalog # 240‑B) inhibits Recombinant Mouse IL‑4 (Catalog # 404-ML) induced proliferation in the HT‑2 mouse T cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Mouse IL‑4 (7.5 ng/mL) activity elicited by Recombinant Human TGF‑ beta 1 (1 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-TGF‑ beta 1, 2, 3 Monoclonal Antibody (Catalog # MAB1835). The ND50 is typically
0.25‑1.25 µg/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TGF-beta 1, 2, 3

TGF-beta 1, -2, and -3 are a closely related group of proteins (70‑80% sequence homology) that are produced by many cell types and function as growth and differentiation factors. The active forms of TGF-beta 1, -2, and -3 are disulfide-linked homodimers.

References
  1. Ayala A. et al. (1992) FASEB J. 6:A1604.
  2. Roberts A.B. and Sporn M.B., eds. (1990) Peptide Growth Factors and Their Receptors I, Springer-Verlag, 419.
  3. Dasch J.R. et al. (1989) J. Immunol. 142:1536.
Long Name
Transforming Growth Factor beta 1, 2, and 3
Alternate Names
CED; DPD1; LAP; TGFB; TGFB1; TGF-beta 1, 2, 3; TGFbeta; transforming growth factor, beta 1

Product Datasheets

Citations for TGF-beta 1, 2, 3 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

129 Citations: Showing 1 - 10
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  1. TGF??1 upregulates the expression of lncRNA?ATB to promote atherosclerosis
    Authors: H Yu, S Ma, L Sun, J Gao, C Zhao
    Mol Med Rep, 2019;19(5):4222-4228.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Capture
  2. Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a
    Authors: S Tiwary, JE Morales, SC Kwiatkowsk, FF Lang, G Rao, JH McCarty
    Sci Rep, 2018;8(1):8267.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  3. TGF-?1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA
    Authors: T Shindo, S Doi, A Nakashima, K Sasaki, K Arihiro, T Masaki
    Sci Rep, 2018;8(1):14060.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  4. BMSCs pre-treatment ameliorates inflammation-related tissue destruction in LPS-induced rat DIC model
    Authors: B Wang, S Wu, Z Ma, T Wang, C Yang
    Cell Death Dis, 2018;9(10):1024.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  5. Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells
    Authors: M Idelson, R Alper, A Obolensky, N Yachimovic, J Rachmilewi, A Ejzenberg, E Beider, E Banin, B Reubinoff
    Stem Cell Reports, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  6. TGF-?1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells
    Authors: X Wang, F Dong, S Zhang, W Yang, W Yu, Z Wang, S Zhang, J Wang, S Ma, P Wu, Y Gao, J Dong, F Tang, T Cheng, H Ema
    Stem Cell Reports, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  7. Connective tissue growth factor expression after angiotensin II exposure is dependent on transforming growth factor-? signaling via the canonical Smad-dependent pathway in hypertensive induced myocardial fibrosis
    Authors: CKS Wong, A Falkenham, T Myers, JF Légaré
    J Renin Angiotensin Aldosterone Syst, 2018;19(1):1470320318759.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  8. Proteomic Analysis of Nucleus Pulposus Cell-derived Extracellular Matrix Niche and Its Effect on Phenotypic Alteration of Dermal Fibroblasts
    Authors: M Yuan, PJ Pai, X Liu, H Lam, BP Chan
    Sci Rep, 2018;8(1):1512.
    Species: Rabbit
    Sample Types: Whole Cells
    Applications: ICC
  9. CD8+ T cells with high TGF??1 expression cause lymph node fibrosis following HIV infection
    Authors: L Huang, J Deng, W Xu, H Wang, L Shi, F Wu, D Wu, W Nei, M Zhao, P Mao, X Zhou
    Mol Med Rep, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Agonist Activity
  10. Downregulation of membrane trafficking proteins and lactate conditioning determine loss of dendritic cell function in lung cancer
    Authors: N Caronni, F Simoncello, F Stafetta, C Guarnaccia, JS Ruiz-Moren, B Opitz, T Galli, V Proux-Gill, F Benvenuti
    Cancer Res., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF??
    Authors: B Liu, L Xu, X Yu, W Li, X Sun, S Xiao, M Guo, H Wang
    Mol Med Rep, 2018;18(2):1987-1994.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  12. Mechanosignaling activation of TGF? maintains intervertebral disc homeostasis
    Authors: Q Bian, L Ma, A Jain, JL Crane, K Kebaish, M Wan, Z Zhang, X Edward Guo, PD Sponseller, CA Séguin, LH Riley, Y Wang, X Cao
    Bone Res, 2017;5(0):17008.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  13. A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw
    Authors: DJ Urban, N Anthwal, ZX Luo, JA Maier, A Sadier, AS Tucker, KE Sears
    Proc. Biol. Sci, 2017;284(1848):.
    Species: Opossum
    Sample Types: In Vivo
    Applications: In Vivo
  14. Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures
    Authors: CJ Bohlen, FC Bennett, AF Tucker, HY Collins, SB Mulinyawe, BA Barres
    Neuron, 2017;94(4):759-773.e8.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  15. Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function
    Authors: RM Petri, A Hackel, K Hahnel, CA Dumitru, K Bruderek, SB Flohe, A Paschen, S Lang, S Brandau
    Stem Cell Reports, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  16. The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study
    Authors: K Brekke, M Sommerfelt, M Ökvist, AM Dyrhol-Rii, D Kvale
    BMC Infect. Dis, 2017;17(1):228.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  17. Granulocytic myeloid derived suppressor cells from human cord blood modulate T-helper-cell response towards an anti-inflammatory phenotype
    Authors: N Köstlin, M Vogelmann, B Spring, J Schwarz, J Feucht, C Härtel, TW Orlikowsky, CF Poets, C Gille
    Immunology, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  18. TGF-? signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes
    Authors: S Khakipoor, C Ophoven, M Schrödl-Hä, M Feuerstein, B Heimrich, JW Deitmer, E Roussa
    Glia, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Neutralization
  19. Integrin ?1 activation induces an anti-melanoma host response
    Authors: L Ritsma, I Dey-Guha, N Talele, X Sole, Salony, J Chowdhury, KN Ross, S Ramaswamy
    PLoS ONE, 2017;12(4):e0175300.
    Species: Human
    Sample Types: Whole Cells
    Applications: Functional Assay
  20. Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3(+) regulatory T cells
    Authors: M Pasztoi, J Pezoldt, M Beckstette, C Lipps, D Wirth, M Rohde, K Paloczi, EI Buzas, J Huehn
    Eur. J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  21. Histone Deacetylase (HDAC) Inhibition Induces I?B Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells
    Authors: HR Gatla, Y Zou, MM Uddin, B Singha, P Bu, A Vancura, I Vancurova
    J. Biol. Chem., 2017;292(12):5043-5054.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  22. ALS skeletal muscle shows enhanced TGF-? signaling, fibrosis and induction of fibro/adipogenic progenitor markers
    Authors: D Gonzalez, O Contreras, DL Rebolledo, JP Espinoza, B van Zunder, E Brandan
    PLoS ONE, 2017;12(5):e0177649.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  23. Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes
    Stem Cell Reports, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  24. Sterile Inflammation Enhances ECM Degradation in Integrin ?1 KO Embryonic Skin
    Cell Rep, 2016;16(12):3334-47.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC - PFA fixed
  25. Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy
    Arthritis Res Ther, 2016;18(1):184.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  26. K+/Cl- cotransporter KCC2 membrane trafficking and functionality is regulated by transforming growth factor beta 2
    J Cell Sci, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion
    PLoS ONE, 2016;11(11):e0166500.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  28. Kluyveromyces marxianus and Saccharomyces boulardii Induce Distinct Levels of Dendritic Cell Cytokine Secretion and Significantly Different T Cell Responses In Vitro
    PLoS ONE, 2016;11(11):e0167410.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  29. Cancer associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-�-dependent pathways in genotype-specific oral cancer
    Authors: S S Prime
    Carcinogenesis, 2016;0(0):.
    Species: Human
    Sample Types: Conditioned Media
    Applications: Neut
  30. TGF-? Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions
    Authors: X Chen, DL Rateri, DA Howatt, A Balakrishn, JJ Moorleghen, LA Cassis, A Daugherty
    PLoS ONE, 2016;11(4):e0153811.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  31. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-? signalling
    Authors: Fatemeh Mirzamoham
    Nat Commun, 2016;7(0):12047.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  32. TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development
    Authors: H Nagashima, Y Okuyama, T Hayashi, N Ishii, T So
    J Immunol, 2016;0(0):.
  33. TGF-?1 Is Present at High Levels in Wound Fluid from Breast Cancer Patients Immediately Post-Surgery, and Is Not Increased by Intraoperative Radiation Therapy (IORT)
    PLoS ONE, 2016;11(9):e0162221.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  34. Mammary epithelial cell phagocytosis downstream of TGF-beta3 is characterized by adherens junction reorganization.
    Authors: Fornetti J, Flanders K, Henson P, Tan A, Borges V, Schedin P
    Cell Death Differ, 2016;23(2):185-96.
    Species: Rat
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  35. Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs
    Nature, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury
    Authors: Jeremy S Duffield
    J. Clin. Invest., 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  37. [64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma
    Authors: I Minn, SM Koo, HS Lee, M Brummet, SP Rowe, MA Gorin, P Sysa-Shah, WD Lewis, HH Ahn, Y Wang, SR Banerjee, RC Mease, S Nimmagadda, ME Allaf, MG Pomper, X Yang
    Oncotarget, 2016;7(35):56471-56479.
    Species: Mink
    Sample Types: Whole Cells
    Applications: Neutralization
  38. Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity.
    Authors: Carrillo-Galvez A, Cobo M, Cuevas-Ocana S, Gutierrez-Guerrero A, Sanchez-Gilabert A, Bongarzone P, Garcia-Perez A, Munoz P, Benabdellah K, Toscano M, Martin F, Anderson P
    Stem Cells, 2015;33(1):183-95.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  39. IL-10 inhibits neuraminidase-activated TGF-beta and facilitates Th1 phenotype during early phase of infection.
    Authors: Dutta A, Huang C, Chen T, Lin C, Chiu C, Lin Y, Chang C, He Y
    Nat Commun, 2015;6(0):6374.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  40. STAT6-Dependent Collagen Synthesis in Human Fibroblasts Is Induced by Bovine Milk.
    Authors: Kippenberger S, Zoller N, Kleemann J, Muller J, Kaufmann R, Hofmann M, Bernd A, Meissner M, Valesky E
    PLoS ONE, 2015;10(7):e0131783.
    Species: Bovine
    Sample Types: Milk
    Applications: Neutralization
  41. Bortezomib inhibits expression of TGF-beta1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells.
    Authors: Chang T, Poltoratsky V, Vancurova I
    J Immunol, 2015;194(6):2942-53.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  42. Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.
    Authors: Rossetti M, Spreafico R, Saidin S, Chua C, Moshref M, Leong J, Tan Y, Thumboo J, van Loosdregt J, Albani S
    J Immunol, 2015;194(1):113-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  43. Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-beta.
    Authors: Ungefroren H, Hyder A, Hinz H, Groth S, Lange H, El-Sayed K, Ehnert S, Nussler A, Fandrich F, Gieseler F
    PLoS ONE, 2015;10(2):e0118097.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  44. Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-beta Signaling in the Retinal Pigment Epithelium.
    Authors: Li Y, Song D, Song Y, Zhao L, Wolkow N, Tobias J, Song W, Dunaief J
    J Biol Chem, 2015;290(19):11918-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  45. Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-beta (TGF-beta) Activation and Fibroblast Differentiation.
    Authors: Dayer C, Stamenkovic I
    J Biol Chem, 2015;290(22):13763-78.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  46. STAT3 governs hyporesponsiveness and granzyme B-dependent suppressive capacity in human CD4+ T cells.
    Authors: Schmetterer K, Neunkirchner A, Wojta-Stremayr D, Leitner J, Steinberger P, Pickl W
    FASEB J, 2015;29(3):759-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Blocking
  47. Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition.
    Authors: Mizuuchi Y, Aishima S, Ohuchida K, Shindo K, Fujino M, Hattori M, Miyazaki T, Mizumoto K, Tanaka M, Oda Y
    Lab Invest, 2015;95(2):193-206.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  48. Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-beta.
    Authors: Pieters B, Arntz O, Bennink M, Broeren M, van Caam A, Koenders M, van Lent P, van den Berg W, de Vries M, van der Kraan P, van de Loo F
    PLoS ONE, 2015;10(3):e0121123.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  49. CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1epsilon transgenic mice.
    Authors: Lin Z, Wang C, Xia H, Liu W, Xiao W, Qian L, Jia X, Ding Y, Ji M, Gong W
    Immunology, 2014;141(3):401-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  50. Functional effects of TGF-beta1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma.
    Authors: Gao P, Zhou Y, Xian L, Li C, Xu T, Plunkett B, Huang S, Wan M, Cao X
    J Immunol, 2014;192(10):4560-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  51. Biglycan and decorin differentially regulate signaling in the fetal membranes.
    Authors: Wu Z, Horgan C, Carr O, Owens R, Iozzo R, Lechner B
    Matrix Biol, 2014;35(0):266-75.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  52. The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-beta.
    Authors: Craft C, Pietka T, Schappe T, Coleman T, Combs M, Klein S, Abumrad N, Mecham R
    Diabetes, 2014;63(6):1920-32.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  53. Angiotensin II-dependent TGF-beta signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
    Authors: Gallo E, Loch D, Habashi J, Calderon J, Chen Y, Bedja D, van Erp C, Gerber E, Parker S, Sauls K, Judge D, Cooke S, Lindsay M, Rouf R, Myers L, ap Rhys C, Kent K, Norris R, Huso D, Dietz H
    J Clin Invest, 2014;124(1):448-60.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  54. Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vdelta 2 T lymphocytes in non-Hodgkin lymphomas.
    Authors: Musso A, Catellani S, Canevali P, Tavella S, Vene R, Boero S, Pierri I, Gobbi M, Kunkl A, Ravetti J, Zocchi M, Poggi A
    Haematologica, 2014;99(1):131-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  55. Influenza promotes collagen deposition via alphavbeta6 integrin-mediated transforming growth factor beta activation.
    Authors: Jolly L, Stavrou A, Vanderstoken G, Meliopoulos V, Habgood A, Tatler A, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli M, Schultz-Cherry S, Jenkins G
    J Biol Chem, 2014;289(51):35246-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  56. The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
    Authors: Nagashima, Hiroyuki, Okuyama, Yuko, Asao, Atsuko, Kawabe, Takeshi, Yamaki, Satoshi, Nakano, Hiroyasu, Croft, Michael, Ishii, Naoto, So, Takanori
    Nat Immunol, 2014;15(5):449-56.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  57. Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation.
    Authors: Faustino L, Fonseca D, Florsheim E, Resende R, Lepique A, Faquim-Mauro E, Gomes E, Silva J, Yagita H, Russo M
    Mucosal Immunol, 2014;7(5):1199-208.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  58. Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome.
    Authors: Cook J, Carta L, Benard L, Chemaly E, Chiu E, Rao S, Hampton T, Yurchenco P, Costa K, Hajjar R, Ramirez F
    J Clin Invest, 2014;124(3):1329-39.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  59. Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-beta.
    Authors: Alcaraz L, Exposito J, Chuvin N, Pommier R, Cluzel C, Martel S, Sentis S, Bartholin L, Lethias C, Valcourt U
    J Cell Biol, 2014;205(3):409-28.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  60. Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion.
    Authors: Hassona Y, Cirillo N, Heesom K, Parkinson E, Prime S
    Br J Cancer, 2014;111(6):1230-7.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Neutralization
  61. Basal localization of MT1-MMP is essential for epithelial cell morphogenesis in 3D collagen matrix.
    Authors: Weaver S, Wolters B, Ito N, Woskowicz A, Kaneko K, Shitomi Y, Seiki M, Itoh Y
    J Cell Sci, 2014;127(0):1203-13.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Neutralization
  62. Bovine gammadelta T cells are a major regulatory T cell subset.
    Authors: Guzman E, Hope J, Taylor G, Smith A, Cubillos-Zapata C, Charleston B
    J Immunol, 2014;193(1):208-22.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  63. CD2-mediated regulation of peripheral CD4(+) CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim.
    Authors: Kashiwakura Y, Sakurai D, Kanno Y, Hashiguchi M, Kobayashi A, Kurosu A, Tokudome S, Kobata T, Kojima H
    Immunology, 2013;139(1):48-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  64. A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.
    Authors: Guo Z, Khattar M, Schroder P, Miyahara Y, Wang G, He X, Chen W, Stepkowski S
    J Immunol, 2013;190(7):3153-62.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  65. Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-beta.
    Authors: Yu C, Becker C, Wang Y, Marches F, Helft J, Leboeuf M, Anguiano E, Pourpe S, Goller K, Pascual V, Banchereau J, Merad M, Palucka K
    Immunity, 2013;38(4):818-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  66. Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress.
    Authors: Gandhi N, Su Z, Zhang X, Volpe E, Pelegrino F, Rahman S, Li D, Pflugfelder S, de Paiva C
    J Leukoc Biol, 2013;94(6):1293-301.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  67. TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement.
    Authors: Bialas A, Stevens B
    Nat Neurosci, 2013;16(12):1773-82.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Immunodepletion
  68. Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity.
    Authors: Norris B, Uebelhoer L, Nakaya H, Price A, Grakoui A, Pulendran B
    Immunity, 2013;38(2):309-21.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  69. Staphylococcus aureus phenol-soluble modulin peptides modulate dendritic cell functions and increase in vitro priming of regulatory T cells.
    Authors: Schreiner J, Kretschmer D, Klenk J, Otto M, Buhring H, Stevanovic S, Wang J, Beer-Hammer S, Peschel A, Autenrieth S
    J Immunol, 2013;190(7):3417-26.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  70. The metalloprotease ADAM12 regulates the effector function of human Th17 cells.
    Authors: Zhou A, El Hed A, Mercer F, Kozhaya L, Unutmaz D
    PLoS ONE, 2013;8(11):e81146.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  71. Peyer's patch inducer cells play a leading role in the formation of B and T cell zone architecture.
    Authors: Nakagawa R, Togawa A, Nagasawa T, Nishikawa S
    J Immunol, 2013;190(7):3309-18.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  72. Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta.
    Authors: Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F
    Nature, 2012;484(7395):514-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  73. TGF-beta signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
    Authors: Zhang N, Bevan MJ
    Nat. Immunol., 2012;13(7):667-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  74. Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets.
    Authors: Montane J, Bischoff L, Soukhatcheva G, Dai DL, Hardenberg G, Levings MK, Orban PC, Kieffer TJ, Tan R, Verchere CB
    J. Clin. Invest., 2011;121(0):3024.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  75. An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.
    Authors: Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ
    Mol. Biol. Cell, 2011;22(10):1686-98.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Neutralization
  76. Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease.
    Authors: Ma W, Han W, Greer PA, Tuder RM, Toque HA, Wang KK, Caldwell RW, Su Y
    J. Clin. Invest., 2011;121(11):4548-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  77. Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance.
    Authors: Chaturvedi V, Collison LW, Guy CS, Workman CJ, Vignali DA
    J. Immunol., 2011;186(12):6661-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  78. Anti-Asthma Simplified Herbal Medicine Intervention-induced long-lasting tolerance to allergen exposure in an asthma model is interferon-gamma, but not transforming growth factor-beta dependent.
    Authors: Srivastava K, Zhang T, Yang N, Sampson H, Li XM
    Clin. Exp. Allergy, 2010;40(11):1678-88.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  79. Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior.
    Authors: Koo JW, Russo SJ, Ferguson D, Nestler EJ, Duman RS
    Proc. Natl. Acad. Sci. U.S.A., 2010;107(6):2669-74.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  80. Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta.
    Authors: Han G, Wang R, Chen G
    Immunology, 2010;129(2):197-206.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  81. Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells.
    Authors: Tso GH, Law HK, Tu W
    Stem Cells, 2010;28(5):939-54.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  82. Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1.
    Authors: Linke A, Goren I, Bosl MR, Pfeilschifter J, Frank S
    J. Invest. Dermatol., 2010;130(3):866-75.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Bioassay
  83. Treatment failure of a TLR-7 agonist occurs due to self-regulation of acute inflammation and can be overcome by IL-10 blockade.
    Authors: Lu H, Wagner WM, Gad E, Yang Y, Duan H, Amon LM, Van Denend N, Larson ER, Chang A, Tufvesson H, Disis ML
    J. Immunol., 2010;184(9):5360-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  84. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.
    Authors: Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, Geffner JR, Rabinovich GA
    Nat. Immunol., 2009;10(9):981-91.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  85. Fractional CO2 laser: a novel therapeutic device upon photobiomodulation of tissue remodeling and cytokine pathway of tissue repair.
    Authors: Prignano F, Campolmi P, Bonan P
    Dermatol Ther, 2009;22(0):S8-15.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  86. TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23.
    Authors: Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M
    Eur. J. Immunol., 2009;39(5):1221-30.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  87. The AP-1 transcription factor Batf controls T(H)17 differentiation.
    Authors: Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM
    Nature, 2009;460(7253):405-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  88. Loss of Thy-1 inhibits alveolar development in the newborn mouse lung.
    Authors: Nicola T, Hagood JS, James ML, Macewen MW, Williams TA, Hewitt MM, Schwiebert L, Bulger A, Oparil S, Chen YF, Ambalavanan N
    Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(5):L738-50.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  89. CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1.
    Authors: Han Y, Guo Q, Zhang M, Chen Z, Cao X
    J. Immunol., 2009;182(1):111-20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  90. Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function.
    Authors: Tran DQ, Glass DD, Uzel G, Darnell DA, Spalding C, Holland SM, Shevach EM
    J. Immunol., 2009;182(5):2929-38.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  91. Characterization of naturally occurring CD4+CD25+ regulatory T cells in rhesus monkeys.
    Authors: Haanstra KG, van der Maas MJ, 't Hart BA, Jonker M
    Transplantation, 2008;85(8):1185-92.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: Neutralization
  92. Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells.
    Authors: van der Vliet HJ, Wang R, Yue SC, Koon HB, Balk SP, Exley MA
    J. Immunol., 2008;180(11):7287-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  93. Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.
    Authors: Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L
    Am. J. Pathol., 2008;172(4):1127-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  94. Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells.
    Authors: Terme M, Chaput N, Combadiere B, Ma A, Ohteki T, Zitvogel L
    J. Immunol., 2008;180(7):4679-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  95. Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling.
    Authors: Pen A, Moreno MJ, Durocher Y, Deb-Rinker P, Stanimirovic DB
    Oncogene, 2008;27(54):6834-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  96. CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells.
    Authors: Perruche S, Zhang P, Liu Y, Saas P, Bluestone JA, Chen W
    Nat. Med., 2008;14(5):528-35.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  97. Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.
    Authors: Carlson ME, Hsu M, Conboy IM
    Nature, 2008;454(7203):528-32.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Neutralization
  98. Molecular mechanisms of TGFbeta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506.
    Authors: Akool el-S, Doller A, Babelova A, Tsalastra W, Moreth K, Schaefer L, Pfeilschifter J, Eberhardt W
    J. Immunol., 2008;181(4):2831-45.
    Species: Rat
    Sample Types: In Vivo
    Applications: In vivo
  99. Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge.
    Authors: He R, Oyoshi MK, Jin H, Geha RS
    Proc. Natl. Acad. Sci. U.S.A., 2007;104(40):15817-22.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  100. In vitro induction of mucosa-type dendritic cells by all-trans retinoic acid.
    Authors: Saurer L, McCullough KC, Summerfield A
    J. Immunol., 2007;179(6):3504-14.
    Species: Porcine
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  101. Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses.
    Authors: Alatrakchi N, Graham CS, van der Vliet HJ, Sherman KE, Exley MA, Koziel MJ
    J. Virol., 2007;81(11):5882-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  102. Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes.
    Authors: Lamar JM, Iyer V, DiPersio CM
    J. Invest. Dermatol., 2007;128(3):575-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  103. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
    Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
    Blood, 2007;109(10):4272-9.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Luminex Development
  104. Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes.
    Authors: Koelle DM, Huang J, Hensel MT, McClurkan CL
    J. Virol., 2006;80(6):2863-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  105. Requirement of Smad3 for mast cell growth.
    Authors: Funaba M, Nakaya K, Ikeda T, Murakami M, Tsuchida K, Sugino H
    Cell. Immunol., 2006;240(1):47-52.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  106. Long-term staphylococcal enterotoxin C1 exposure induces soluble factor-mediated immunosuppression by bovine CD4+ and CD8+ T cells.
    Authors: Seo KS, Lee SU, Park YH, Davis WC, Fox LK, Bohach GA
    Infect. Immun., 2006;75(1):260-9.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Neutralization
  107. Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cells.
    Authors: Dasgupta S, Bhattacharya-Chatterjee M, O&amp;amp;apos;Malley BW, Chatterjee SK
    J. Cell. Biochem., 2006;97(5):1036-51.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC Frozen
  108. Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction.
    Authors: Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S
    Gut, 2006;56(2):243-52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  109. Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.
    Authors: Neurohr C, Nishimura SL, Sheppard D
    Am. J. Respir. Cell Mol. Biol., 2006;35(2):252-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  110. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct.
    Authors: Maeshima A, Vaughn DA, Choi Y, Nigam SK
    Dev. Biol., 2006;295(2):473-85.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: Neutralization
  111. IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells.
    Authors: Rosendahl AH, Forsberg G
    Kidney Int., 2006;70(9):1584-90.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  112. Transforming growth factor beta1 regulates follistatin mRNA expression during in vitro bovine granulosa cell differentiation.
    Authors: Fazzini M, Vallejo G, Colman-Lerner A, Trigo R, Campo S, Baranao JL, Saragueta PE
    J. Cell. Physiol., 2006;207(1):40-8.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Neutralization
  113. Retinal neurons regulate proliferation of postnatal progenitors and Muller glia in the rat retina via TGF beta signaling.
    Authors: Close JL, Gumuscu B, Reh TA
    Development, 2005;132(13):3015-26.
    Species: Rat
    Sample Types: In Vivo
    Applications: In vivo
  114. Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
    Authors: Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB
    Blood, 2005;105(2):750-8.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Neutralization
  115. Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta.
    Authors: Huang X, Zhu J, Yang Y
    J. Immunol., 2005;175(7):4283-91.
    Species: Mouse
    Sample Types:
    Applications: Neutralization
  116. P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2.
    Authors: Paliwal S, Shi J, Dhru U, Zhou Y, Schuger L
    Biochem. Biophys. Res. Commun., 2004;315(4):1104-9.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  117. In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures.
    Authors: Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, Blazar BR, Porter SB
    Blood, 2004;104(2):453-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  118. Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells.
    Authors: Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, Qiuping Z, Junyan L, Zhang X, Jinquan T
    Immunology, 2004;112(2):274-89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  119. TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.
    Authors: Kitani A, Fuss I, Pedersen A, Nawata H
    J. Immunol., 2004;172(2):834-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  120. Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates.
    Authors: Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ
    J. Immunol., 2004;172(9):5753-64.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  121. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.
    Authors: Chen, WanJun, Jin, Wenwen, Hardegen, Neil, Lei, Ke-Jian, Li, Li, Marinos, Nancy, McGrady, George, Wahl, Sharon M
    J Exp Med, 2003;198(12):1875-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  122. Immunosuppression in hamsters with progressive visceral leishmaniasis is associated with an impairment of protein kinase C activity in their lymphocytes that can be partially reversed by okadaic acid or anti-transforming growth factor beta antibody.
    Authors: Mookerjee A, Sen PC, Ghose AC
    Infect. Immun., 2003;71(5):2439-46.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: Neutralization
  123. IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression.
    Authors: Koenen HJ, Fasse E, Joosten I
    J. Immunol., 2003;171(12):6431-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  124. Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice.
    Authors: Kobayashi T, Iijima K, Kita H
    J. Immunol., 2003;170(11):5756-63.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo
  125. The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure.
    Authors: Feugate JE, Li Q, Wong L, Martins-Green M
    J. Cell Biol., 2002;156(1):161-72.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Neutralization
  126. Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta.
    Authors: Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J
    Immunol Cell Biol, 0;94(8):747-62.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  127. PARP-1 regulates expression of TGF-beta receptors in T cells.
    Authors: Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, Konkel J, Maruyama T, Wei G, Abbatiello B, Wang Z, Zhao K, Chen W
    Blood, 0;122(13):2224-32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  128. Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-beta Signaling.
    Authors: Carthy J, Engstrom U, Heldin C, Moustakas A
    J Cell Biochem, 0;117(4):938-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  129. A mechanism linking Id2-TGFbeta crosstalk to reversible adaptive plasticity in neuroblastoma.
    Authors: Chakrabarti L, Wang B, Lee N, Sandler A
    PLoS ONE, 0;8(12):e83521.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Western Blot

FAQs

  1. Can the TGF-beta 1, 2, 3 Antibody, Cat# MAB1835, neutralize the activity of all three TGF-beta proteins?

    • Yes, this antibody can neutralize the activity of TGF-beta 1, 2, and 3 proteins.

View all Antibody FAQs

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TGF-beta 1, 2, 3 Antibody
By Anonymous on 04/30/2019
Application: WB Sample Tested: Muscle tissue Species: Mouse

TGF-beta 1, 2, 3 Antibody
By Anonymous on 03/28/2019
Application: ELISA Sample Tested: Recombinant protein Species: Human

TGF-beta 1, 2, 3 Antibody
By Anonymous on 01/28/2019
Application: WB Sample Tested: Skin cancer tissue Species: Mouse

TGF-beta 1, 2, 3 Antibody
By Anonymous on 05/22/2018
Application: IHC Sample Tested: Tonsil tissue Species: Human

TGF-beta 1, 2, 3 Antibody
By Anonymous on 04/24/2018
Application: IHC Sample Tested: Skin cancer tissue Species: Mouse

TGF-beta 1, 2, 3 Antibody
By Anonymous on 07/21/2017
Application: ICC/IF Sample Tested: A549 human lung carcinoma cell line Species: Human

TGF-beta 1, 2, 3 Antibody
By Anonymous on 05/16/2017
Application: B/N Sample Tested: Peritoneal macrophages Species: Mouse