Viral CCI Antibody Summary
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
CCI Inhibition of CCL2/JE-dependent Chemotaxis and Neutralization by Viral CCI Antibody. Recombinant Viral CCI Fc Chimera (Catalog # 696‑CC) inhibits Recombinant Mouse CCL2/JE (Catalog # 479‑JE) induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with human CCR2A in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Inhibition of Recombinant Mouse CCL2/JE (20 ng/mL) activity elicited by Recombinant Viral CCI Fc Chimera (0.4 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Viral CCI Antigen Affinity-purified Polyclonal Antibody (Catalog # AF696). The ND50 is typically 3-15 µg/mL.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
The family of T1/35 kDa proteins are secreted, soluble proteins encoded by the 35K virulence gene of many poxviruses. These proteins bind CC chemokines with high affinity and are now termed viral chemokine inhibitors (vCCI). Vaccinia virus (Strain Lister) vCCI shows greater than 90% amino acid sequence identity with vCCI from other orthopoxviruses and approximately 40% amino acid sequence identity with the leporipoxvirus T-1 proteins.
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