Zebrafish BMP-2/BMP-4 Antibody

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Product Details
Supplemental Products

Zebrafish BMP-2/BMP-4 Antibody Summary

Species Reactivity
Detects zebrafish BMP‑2 and BMP‑4 in direct ELISAs and Western blots.
Monoclonal Mouse IgG1 Clone # 169125
Protein A or G purified from hybridoma culture supernatant
E. coli-derived recombinant zebrafish BMP‑4
Accession # NP_571417
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
1 µg/mL
Recombinant Zebrafish BMP‑4 (Catalog # 1128-BM)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: BMP-2/BMP-4

BMP-4 is one of at least 15 structurally and functionally-related BMPs, which are members of the transforming growth factor-beta  (TGF-beta ) superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. They have since been shown to have roles in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis, and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells, and neuronal cells. Similarly to other TGF-beta superfamily proteins, BMPs are highly conserved across animal species. Zebrafish BMP-4 shares 73% amino acid (aa) sequence identity with human and murine BMP-4, and 86% aa identity with zebrafish BMP-2b. Zebrafish BMP-4 mRNA is detected throughout embryonic development and has been detected in tissues of adult fish, including the brain, heart, digestive tracts, testes, and jaw. BMP-4 has been shown to play roles in directing zebrafish heart looping and in ear development. The combined expression pattern of zBMP-2a/2b/4 coincides with areas where BMP-2/4 expression would be found in other vertebrates. Biologically active BMP-4 is a disulfide-linked homodimer of the carboxy-terminal 113 aa that contains the characteristic seven conserved cysteine residues involved in the formation of the cysteine knot and the single interchain disulfide bond.

  1. Kawabata, M. et al. (1998) Cytokine and Growth Factor Reviews 9:49.
  2. Hwang, S.P. et al. (1997) DNA Cell Biol. 16:1003.
  3. Martinez-Barbera, J.P. et al. (1997) Gene 197:53.
  4. Mowbray, C. et al. (2001) Mech Dev. 108:179.
  5. Chen J.N. et al. (1997) Development 124:4373.
Long Name
Bone Morphogenetic Protein 2/4
Entrez Gene IDs
650 (Human); 12156 (Mouse); 29373 (Rat)
Alternate Names
BDA2; BMP-2; BMP-2/BMP-4; BMP2A; BMP-2A; BMP2ABone morphogenetic protein 2A; bone morphogenetic protein 2

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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

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