CRBN: Products

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CRBN-6-5-5-VHL 

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

Human CRBN Antibody 

2 Images
ICC/IF, IHC

Lenalidomide 

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Thalidomide 

Binds cereblon; also TNF-α synthesis inhibitor

Pomalidomide 4'-PEG2-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Pomalidomide 4'-PEG3-acid 

Cereblon ligand with PEG linker and terminal acid for onward chemistry

dTAG-13-NEG 

Negative control for dTAG-13 (Cat. No. 6605)

Pomalidomide 4'-PEG1-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

TC E3 5031 

Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs

Pomalidomide 4'-alkylC5-acid 

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Pomalidomide 4'-alkylC5-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-alkylC2-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Thalidomide 4'-ether-PEG3-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Thalidomide 4'-ether-PEG5-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Pomalidomide 4'-PEG4-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Lenalidomide 4'-PEG2-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Pomalidomide 4'-PEG1-acid 

Cereblon ligand with PEG linker and terminal acid for onward chemistry

Pomalidomide 4'-PEG5-acid 

Cereblon ligand with PEG linker and terminal acid for onward chemistry

Pomalidomide 4'-alkylC3-acid 

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Pomalidomide 4'-PEG3-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Pomalidomide 4'-alkylC7-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Pomalidomide 4'-alkylC8-acid 

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Pomalidomide 4'-PEG2-acid 

Cereblon ligand with PEG linker and terminal acid for onward chemistry

Pomalidomide 4'-PEG4-acid 

Cereblon ligand with PEG linker and terminal acid for onward chemistry

Thalidomide-Cyanine 5 

High affinity cereblon fluorescent probe

Thalidomide 4'-ether-alkylC2-acid 

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Thalidomide 4'-ether-alkylC4-acid 

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Recombinant Human CUL4A/NEDD8/RBX1/DDB1/CRBN Protein, CF 

His10 Complex
1 Image
Bioactivity

Thalidomide 4'-oxyacetamide-alkylC4-azide 

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Thalidomide 4'-oxyacetamide-PEG3-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-PEG4-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-alkylC4-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Thalidomide 4'-ether-alkylC6-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

TC E3 5032 

Precursor to Pomalidomide-based PROTACs

Thalidomide, propargyl 

Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs

Thalidomide 4'-ether-PEG2-alkyne 

Cereblon ligand with PEG linker and terminal alkyne for onward chemistry

Thalidomide 4'-ether-alkylC2-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Pomalidomide 4'-alkylC2-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine 

Cereblon ligand with alkyl-PEG-alkyl linker and terminal amine for onward chemistry

Thalidomide 4'-ether-alkylC4-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Pomalidomide 4'-alkylC8-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-alkylC8-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-PEG1-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-PEG2-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Thalidomide 4'-oxyacetamide-alkylC6-amine 

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Lenalidomide 4'-PEG1-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Lenalidomide 4'-PEG3-amine 

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Pomalidomide 4'-alkylC7-acid 

Cereblon ligand with alkyl linker and terminal acid for onward chemistry
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