11 results for "CRISPR Reagents" in Products

CRISPR Reagents

CRISPR (clustered regularly interspaced short palindromic repeats) is a technology for the targeted editing and regulation of genes that can be applied to a number of biological systems. Tocris offers small molecules that can enhance the efficiency of the CRISPR-mediated gene editing process.

CRISPR are sections of prokaryotic DNA that mediate an acquired immune response against invading plasmids and viruses. The CRISPR locus is composed of Cas (CRISPR associated) genes, a leader sequence and ...

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Metabolite of tamoxifen (Cat. No. 0999)

Alternate Names: 4-OH-TAM
Chemical Name: 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
Purity: ≥98%
Metabolite of tamoxifen (Cat. No. 0999)
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Potent and selective DNA-PK inhibitor

Alternate Names: KU 57788
Chemical Name: 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
Purity: ≥98%
Potent and selective DNA-PK inhibitor
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Viral transduction enhancer

Alternate Names: Hexadimethrine bromide
Chemical Name: 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide
Purity: ≥95%
Viral transduction enhancer
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Microtubule inhibitor

Chemical Name: [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester
Purity: ≥95%
Microtubule inhibitor
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Disrupts protein translocation to Golgi

Chemical Name: 1,6,7,8,9,11aβ,12,13,14,14aα-Decahydro-1β,13α-dihydroxy-6β-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
Purity: ≥98%
Disrupts protein translocation to Golgi
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Cdk1 inhibitor

Chemical Name: 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
Purity: ≥98%
Cdk1 inhibitor
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Potent and selective Cdc7 inhibitor

Alternate Names: BMS 863233
Chemical Name: 8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
Purity: ≥98%
Potent and selective Cdc7 inhibitor
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Potent DNA-PK inhibitor; also increases CRISPR-Cas9 deletion efficiency

Chemical Name: 8-(4-Dibenzothienyll)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one
Purity: ≥98%
Potent DNA-PK inhibitor
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Cell permeable and reversible Cas9 inhibitor

Chemical Name: (3aR,4R,9bR)-8-(2-Fluorophenyl)-2,3,3a,4,5,9b-hexahydro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[3,2-c]quinoline-4-methanol
Purity: ≥98%
Cell permeable and reversible Cas9 inhibitor
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Potent hepatitis C virus (HCV) NS3 protease inihibitor

Chemical Name: 1-[[N-tert-Butoxycarbonyl-L-tert-leucyl-trans-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-L-prolyl]amino]-N-(cyclopropylsulfonyl)-(1R,2S)-2-vinylcyclopropane-1-carboxamide
Purity: ≥98%
Potent hepatitis C virus (HCV) NS3 protease inihibitor
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preQ1 with alkyne handle for click chemistry

Chemical Name: N-[6-[[(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]amino]hexyl]-3-(2-propyn-1-yloxy)propanamide
Purity: ≥95%
preQ1 with alkyne handle for click chemistry
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