Lipid Nanoparticle Components Small Molecules and Peptides

What are Lipid Nanoparticles?

Lipid nanoparticles (LNPs) are lipid based delivery systems commonly used for delivering bioactive nucleic acid payloads into living cells. LNPs are nanometer-sized particles (< 100 nm) comprised of a lipid monolayer shell surrounding an internal core packed with cargo molecules encapsulated in reverse micelles.

Figure 1: Structure and component of lipid nanoparticle carriers. Nucleic acid cargos are stabilized by the ionizable lipids and contained in reverse ...