Human ACE-2 DuoSet ELISA

Catalog # Availability Size / Price Qty
DY933-05
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Human ACE-2 DuoSet ELISA Summary

Specificity
Please see the product datasheet

* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.

Product Datasheets

Preparation and Storage

Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: ACE-2

Angiotensin converting enzyme 2 (ACE-2), also known as ACEH (ACE homolog), is an integral membrane protein and a zinc metalloprotease of the ACE family. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. ACE-2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2 . Amongst ongoing research into the cellular entry mechanism of coronavirus via ACE-2, an anti-human ACE-2 antibody (R&D Systems Catalog # AF933) has blocked this interaction.

Long Name:
Angiotensin I Converting Enzyme 2
Entrez Gene IDs:
59272 (Human); 70008 (Mouse); 302668 (Rat); 100144303 (Porcine); 480847 (Canine); 102130864 (Cynomolgus Monkey); 554349 (Feline); 101823817 (Hamster); 108390919 (Malayan Pangolin)
Alternate Names:
ACE2; ACE-2; ACEH; ACEHangiotensin I converting enzyme 2; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; DKFZp434A014; EC 3.4.17; EC 3.4.17.23; Metalloprotease MPROT15

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