Detection of CCR11 in HEK293 Human Cell Line Transfected with Human CCR11 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with either (A) human CCR11 or (B) irrelevant transfectants and eGFP was stained with Mouse Anti-Human CCR11 Monoclonal Antibody (Catalog # MAB6899) followed by Allophycocyanin-conjugated Anti-Mouse IgM Secondary Antibody (Catalog # F0117). Quadrant markers were set based on control antibody staining. View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
Sterile PBS to a final concentration of 0.5 mg/mL.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
CCR11, also known as CCRL1 and CCX-CKR, is a 45 kDa 7-transmembrane segment protein that is widely expressed on stromal cells. It is a silent receptor that does not induce intracellular calcium signaling, but instead serves as a chemokine scavenger receptor. CCR11 regulates dendritic cell and thymic precursor migration by mediating the clearance of the homeostatic chemokines CCL19, 21, and 25. It is upregulated on some breast cancer cells and on bronchial epithelial cells in pulmonary sarcoidosis. Human CCR11 shares 85% amino acid sequence identity with mouse and rat CCR11.
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