Human CCR5 Antibody

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Product Details
Citations (8)
Supplemental Products
Reviews (1)

Human CCR5 Antibody Summary

Species Reactivity
Detects human CCR5 in direct ELISAs and Western blots. For additional information regarding epitope specificity for this antibody and other R&D Systems anti-human CCR5 antibodies, see reference 1 below.
Monoclonal Mouse IgG1 Clone # CTC8
Protein A or G purified from hybridoma culture supernatant
CHO Chinese hamster ovary cell line transfected with human CCR5
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
Lee, B. et al. (1999) J. Biol. Chem. 274:9617.
Mirzabekov, T. et al. (1999) J. Biol. Chem. 274:28745.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CCR5

CCR5 is a G protein-linked seven transmembrane domain chemokine receptor. CCR5 serves as a receptor for several chemokines including MIP-1 alpha, MIP-1 beta, MCP-2, and RANTES. It also functions as a co‑receptor for Macrophage Tropic HIV-1 infection.

  1. Lee, B. et al. (1999) J. Biol. Chem. 274:9617.
Entrez Gene IDs
1234 (Human); 12774 (Mouse); 117029 (Rat); 484789 (Canine); 493769 (Feline)
Alternate Names
C-C CKR-5; C-C motif chemokine receptor 5 A159A; CCCKR5; CC-CKR-5FLJ78003; CCR5; CCR-5; CD195 antigen; CD195; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; chemr13; CKR5; CKR-5; HIV-1 fusion coreceptor; IDDM22CMKBR5C-C chemokine receptor type 5

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Citations for Human CCR5 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

8 Citations: Showing 1 - 8
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  1. CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells
    Authors: James M. Fox, Richard Kasprowicz, Oliver Hartley, Nathalie Signoret
    Journal of Leukocyte Biology
  2. Identifying CCR5 coreceptor populations permissive for HIV-1 entry and productive infection: implications for in vivo studies
    Authors: M Weichseldo, Y Tagaya, M Reitz, AL DeVico, OS Latinovic
    Journal of Translational Medicine, 2022-01-24;20(1):39.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  3. A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody.
    Authors: Chain B, Arnold J, Akthar S, Brandt M, Davis D, Noursadeghi M, Lapp T, Ji C, Sankuratri S, Zhang Y, Govada L, Saridakis E, Chayen N
    PLoS ONE, 2015-06-01;10(6):e0128381.
    Species: Human
    Sample Types: Peptide, Whole Cells
    Applications: ELISA Development, Flow Cytometry
  4. Preferential recognition of monomeric CCR5 expressed in cultured cells by the HIV-1 envelope glycoprotein gp120 for the entry of R5 HIV-1.
    Authors: Nakano Y, Monde K, Terasawa H, Yuan Y, Yusa K, Harada S, Maeda Y
    Virology, 2014-01-31;452(0):117-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. A role for microRNA-155 modulation in the anti-HIV-1 effects of Toll-like receptor 3 stimulation in macrophages.
    Authors: Swaminathan G, Rossi F, Sierra L, Gupta A, Navas-Martin S, Martin-Garcia J
    PLoS Pathog, 2012-09-20;8(9):e1002937.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  6. A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5.
    Authors: Tilton J, Wilen C, Didigu C, Sinha R, Harrison J, Agrawal-Gamse C, Henning E, Bushman F, Martin J, Deeks S, Doms R
    J Virol, 2010-08-11;84(20):10863-76.
  7. CCL3 (MIP-1alpha) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2.
    Authors: Ottonello L, Montecucco F, Bertolotto M, Arduino N, Mancini M, Corcione A, Pistoia V, Dallegri F
    Cell. Signal., 2005-03-01;17(3):355-63.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  8. A cell-based multiplex immunoassay platform using fluorescent protein-barcoded reporter cell lines
    Authors: Shengli Song, Miriam Manook, Jean Kwun, Annette M. Jackson, Stuart J. Knechtle, Garnett Kelsoe
    Communications Biology


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Human CCR5 Antibody
By Md Munan Shaik on 03/16/2017
Application: WB Sample Tested: Whole cell lysate Species: Whole cell lysate

Its not specific and recognize many band.

Technical Service is following up on this.