Human Coagulation Factor XIV/Protein C Antibody
Human Coagulation Factor XIV/Protein C Antibody Summary
Accession # P04070
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Coagulation Factor XIV/Protein C
Coagulation factor XIV, also known as Protein C, has anti-coagulation activity by degrading factors VIIIa and Va, which are required for thrombin activation. Protein C deficiency results in hereditary thrombophilia, and a severe recessive form may result in massive thrombosis fatal to patient. The deduced amino acid sequence of human protein C predicts a signal peptide (aa 1‑32), a propeptide (aa 33‑42), and a mature chain (aa 43‑461), which can be converted into two disulfide-linked chains (light: aa 43‑199 and heavy: aa 200‑461). The amino acid sequence of human protein C is 99.8%, 80%, 70%, 69% and 54% identical to that of chimpanzee, canine, rat, mouse and chicken.
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