Human DGAT2 Antibody

DGAT2 (Diacylglycerol O-acyltransferase 2; also DGAT2 alpha ) is a 45-50 kDa, insulin-regulated member of the DGAT2 family of enzymes. Although DGAT1 also exists, it is related to DGAT2 only by function; DGAT1 and DGAT2 are members of structurally unrelated gene families. DGAT2 catalyzes the formation of triglyceride (TG) from sn-1, 2-DG and a variety of acyl-CoAs. It is found in sebaceous gland cells, adipocytes, and hepatocytes, and appears to synthesize TGs for incorporation into VLDL particles. Human DGAT2 is a 388 amino acid (aa) multipass ER protein. It contains a 69 aa N-terminal cytoplasmic region, a short luminal sequence (aa 89-92) and a long C-terminal cytoplasmic domain that contains acyl transferase activity (aa 113-388). DGAT2 does homomultimerize, forming 680 kDa complexes. There is one splice variant that contains a deletion of aa 41-83. Over aa 268-377, human DGAT2 shares 95% aa sequence identity with mouse DGAT2.