Human FGFR2 alpha Antibody

Catalog # Availability Size / Price Qty
MAB6841-SP
MAB6841-500
MAB6841-100
Product Details
Citations (4)
FAQs
Supplemental Products
Reviews

Human FGFR2 alpha Antibody Summary

Species Reactivity
Human
Specificity
Detects human FGF R2 alpha in direct ELISAs and Western blots. Recognizes an epitope within the first Ig-like domain that is present only in  alpha isoforms of human FGF R2. Does not cross-react with  alpha isoforms of recombinant mouse FGF R2.
Source
Monoclonal Mouse IgG1 Clone # 98706
Purification
Protein A or G purified from ascites
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human FGF R2 isoforms and Mouse myeloma cell line NS0-derived recombinant human FGF R2 isoforms
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human FGF R2 alpha (IIIb) Fc Chimera (Catalog # 663-FR)
Recombinant Human FGF R2 alpha (IIIc) Fc Chimera (Catalog # 712-FR)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: FGFR2 alpha

FGF activity is mediated by a family of type I transmembrane tyrosine kinases, which undergo dimerization and autophosphorylation after ligand binding. Five distinct genes encode closely related FGF receptors, FGF R1 through 5. FGF Rs contain three Ig-like domains and a stretch of acidic residues between the first and second Ig-like domains. FGF R1, 2, 3, and -4 have a cytoplasmic split tyrosine-kinase domain, but FGF R5 does not. Multiple forms of FGF R1, 2, and 3 are generated by alternative splicing

Long Name
Fibroblast Growth Factor Receptor 2 alpha
Entrez Gene IDs
2263 (Human); 14183 (Mouse)
Alternate Names
FGF R2a; FGFR2 alpha

Product Datasheets

Citations for Human FGFR2 alpha Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors
    Authors: N Schäfer, GH Gielen, L Rauschenba, S Kebir, A Till, R Reinartz, M Simon, P Niehusmann, C Kleinschni, U Herrlinger, T Pietsch, B Scheffler, M Glas
    J Transl Med, 2019;17(1):96.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  2. Acquired resistance to LY2874455 in FGFR2-amplified gastric cancer through an emergence of novel FGFR2-ACSL5 fusion
    Authors: SY Kim, T Ahn, H Bang, JS Ham, J Kim, ST Kim, J Jang, M Shim, SY Kang, SH Park, BH Min, H Lee, WK Kang, KM Kim, W Park, J Lee
    Oncotarget, 2017;8(9):15014-15022.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  3. FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival.
    Authors: Mathur, Anjili, Ware, Christop, Davis, Lenora, Gazdar, Adi, Pan, Bo-Sheng, Lutterbach, Bart
    PLoS ONE, 2014;9(6):e98515.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival.
    Authors: Kunii K, Davis L, Gorenstein J, Hatch H, Yashiro M, Di Bacco A, Elbi C, Lutterbach B
    Cancer Res., 2008;68(7):2340-8.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation

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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

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