Human GABA-A R alpha 1 (NP_000797) VersaClone cDNA

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RDC0689
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Human GABA-A R alpha 1 (NP_000797) VersaClone cDNA Summary

GABA A (γ-aminobutyric acid-type A) receptors are members of the cysteine-loop family of neurotransmitter-gated ion channels. GABA binding to A-type receptors induces anion-selective ion channel opening. These receptors are the principal fast inhibitory neurotransmitter receptors in the CNS. GABA A receptors are heteropentamer combinations of seven subunit types; α, β, γ, δ, ε, θ, and π. Three subunits, α, β, and γ, have at least three separate gene products in mammals, and typical GABA A receptors have some combination of α, β, and γ subunits.

The rat α1 isoform is a 50 - 52 kDa, 428 amino acid (aa), 4 transmembrane protein with two terminal extracellular regions. The ligand-binding region is in the N-terminus (aa 15 - 222). As with many receptors, phosphorylation of GABA A R is used as a regulatory mechanism. CaM kinase II is known to phosphorylate the a1 GABA A subunit and regulate benzodiazepine binding. The α1 subunits are particularly abundant in the cerebellum and may contribute to GABA receptor distribution. In the hippocampus and amygdala, the α1 GABA A subunit may contribute to amnesia.

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

Background: GABA-A R alpha 1

Long Name
gamma-Aminobutyric Acid Type A Receptor, alpha-1 Polypeptide
Entrez Gene IDs
2554 (Human); 14394 (Mouse); 29705 (Rat); 282235 (Bovine)
Alternate Names
ECA4; EJM; EJM5GABA(A) receptor subunit alpha-1; GABA A R alpha 1; GABAAR alpha 1; GABAARa1; GABRA1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid receptor subunit alpha-1

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