Human HTRA1/PRSS11 Antibody

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Detection of Human HTRA1/PRSS11 by Western Blot.
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Product Details
Citations (12)
Supplemental Products

Human HTRA1/PRSS11 Antibody Summary

Species Reactivity
Detects human HTRA1/PRSS11 in direct ELISAs and Western blots.
Monoclonal Mouse IgG2B Clone # 275615
Protein A or G purified from hybridoma culture supernatant
Mouse myeloma cell line NS0-derived recombinant human HTRA1/PRSS11
Accession # Q92743
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
1 µg/mL
See below
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Human HTRA1/PRSS11, see our available Western blot detection antibodies

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human HTRA1/PRSS11 antibody by Western Blot. View Larger

Detection of Human HTRA1/PRSS11 by Western Blot. Western blot shows lysates of human placenta tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human HTRA1/PRSS11 Monoclonal Antibody (Catalog # MAB2916) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for HTRA1/PRSS11 at approximately 51 kDa (as indicated). This experiment was conducted under non-reducing conditions and using Immunoblot Buffer Group 1.

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: HTRA1/PRSS11

HTRA1 is a serine protease encoded by the PRSS11 gene and is expressed in many tissues. HTRA1 regulates the availability of IGFs by cleaving IGFBPs.

Long Name
High Temperature Requirement Protein-1
Entrez Gene IDs
5654 (Human)
Alternate Names
ARMD7; EC 3.4.21; EC; High-temperature requirement A serine peptidase 1; HtrA serine peptidase 1; HTRA1; IGFBP5-protease; L56; ORF480; PRSS11; Serine protease 11; serine, 11 (IGF binding)

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Citations for Human HTRA1/PRSS11 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

12 Citations: Showing 1 - 10
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  1. Spliceosomal disruption of the non-canonical BAF complex in cancer
    Authors: D Inoue, GL Chew, B Liu, BC Michel, J Pangallo, AR D'Avino, T Hitchman, K North, SC Lee, L Bitner, A Block, AR Moore, A Yoshimi, L Escobar-Ho, H Cho, A Penson, SX Lu, J Taylor, Y Chen, C Kadoch, O Abdel-Waha, RK Bradley
    Nature, 2019-10-09;0(0):.
    Species: Mouse
    Sample Types: Protein
    Applications: Western Blot
  2. Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer's disease
    Authors: DC Hondius, KN Eigenhuis, THJ Morrema, RC van der Sc, P van Nierop, M Bugiani, KW Li, JJM Hoozemans, AB Smit, AJM Rozemuller
    Acta Neuropathol Commun, 2018-06-04;6(1):46.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  3. HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development
    Authors: S Yamawaki, M Naitoh, H Kubota, R Aya, Y Katayama, T Ishiko, T Tamura, K Yoshikawa, T Enoshiri, M Ikeda, S Suzuki
    Int J Mol Sci, 2018-04-24;19(5):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. High-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling
    Authors: O Globus, T Evron, M Caspi, R Siman-Tov, R Rosin-Arbe
    Sci Rep, 2017-12-21;7(1):17995.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  5. HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
    Authors: E Melo, P Oertle, C Trepp, H Meisterman, T Burgoyne, L Sborgi, AC Cabrera, CY Chen, JC Hoflack, T Kam-Thong, R Schmucki, L Badi, N Flint, ZE Ghiani, F Delobel, C Stucki, G Gromo, A Einhaus, B Hornsperge, S Golling, J Siebourg-P, F Gerber, B Bohrmann, C Futter, T Dunkley, S Hiller, O Schilling, V Enzmann, S Fauser, M Plodinec, R Iacone
    EBioMedicine, 2017-12-13;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation
  6. Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations
    Authors: Chi Pui Pang
    Lab. Invest., 2016-11-14;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: ICC, Western Blot
  7. HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration
    Authors: Tsz Kin Ng
    Sci Rep, 2016-06-24;6(0):28639.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  8. Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease.
    Authors: Jo, Hakryul, Patterson, Victoria, Stoessel, Sean, Kuan, Chia-Yi, Hoh, Josephin
    PLoS ONE, 2014-12-15;9(12):e115362.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  9. Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium.
    Authors: Kumar, Sandeep, Berriochoa, Zachary, Ambati, Balamura, Fu, Yingbin
    Invest Ophthalmol Vis Sci, 2014-05-22;55(6):3842-50.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  10. Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1.
    Authors: Jacobo, Sarah Me, Deangelis, Margaret, Kim, Ivana K, Kazlauskas, Andrius
    Mol Cell Biol, 2013-03-11;33(10):1976-90.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Immunoprecipitation
  11. Down-Regulation of HtrA1 Activates the Epithelial-Mesenchymal Transition and ATM DNA Damage Response Pathways.
    Authors: Wang N, Eckert KA, Zomorrodi AR
    PLoS ONE, 2012-06-26;7(6):e39446.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  12. Matrix remodeling as stem cell recruitment event: a novel in vitro model for homing of human bone marrow stromal cells to the site of injury shows crucial role of extracellular collagen matrix.
    Authors: Mauney J, Olsen BR, Volloch V
    Matrix Biol., 2010-09-07;29(8):657-63.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation


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