Human HTRA1/PRSS11 Antibody Summary
Gln23-Pro480
Accession # Q92743
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human HTRA1/PRSS11 by Western Blot. Western blot shows lysates of human placenta tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human HTRA1/PRSS11 Monoclonal Antibody (Catalog # MAB2916) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for HTRA1/PRSS11 at approximately 51 kDa (as indicated). This experiment was conducted under non-reducing conditions and using Immunoblot Buffer Group 1.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: HTRA1/PRSS11
HTRA1 is a serine protease encoded by the PRSS11 gene and is expressed in many tissues. HTRA1 regulates the availability of IGFs by cleaving IGFBPs.
Product Datasheets
Citations for Human HTRA1/PRSS11 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
12
Citations: Showing 1 - 10
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Spliceosomal disruption of the non-canonical BAF complex in cancer
Authors: D Inoue, GL Chew, B Liu, BC Michel, J Pangallo, AR D'Avino, T Hitchman, K North, SC Lee, L Bitner, A Block, AR Moore, A Yoshimi, L Escobar-Ho, H Cho, A Penson, SX Lu, J Taylor, Y Chen, C Kadoch, O Abdel-Waha, RK Bradley
Nature, 2019-10-09;0(0):.
Species: Mouse
Sample Types: Protein
Applications: Western Blot -
Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer's disease
Authors: DC Hondius, KN Eigenhuis, THJ Morrema, RC van der Sc, P van Nierop, M Bugiani, KW Li, JJM Hoozemans, AB Smit, AJM Rozemuller
Acta Neuropathol Commun, 2018-06-04;6(1):46.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloid Development
Authors: S Yamawaki, M Naitoh, H Kubota, R Aya, Y Katayama, T Ishiko, T Tamura, K Yoshikawa, T Enoshiri, M Ikeda, S Suzuki
Int J Mol Sci, 2018-04-24;19(5):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
High-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling
Authors: O Globus, T Evron, M Caspi, R Siman-Tov, R Rosin-Arbe
Sci Rep, 2017-12-21;7(1):17995.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
Authors: E Melo, P Oertle, C Trepp, H Meisterman, T Burgoyne, L Sborgi, AC Cabrera, CY Chen, JC Hoflack, T Kam-Thong, R Schmucki, L Badi, N Flint, ZE Ghiani, F Delobel, C Stucki, G Gromo, A Einhaus, B Hornsperge, S Golling, J Siebourg-P, F Gerber, B Bohrmann, C Futter, T Dunkley, S Hiller, O Schilling, V Enzmann, S Fauser, M Plodinec, R Iacone
EBioMedicine, 2017-12-13;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Immunoprecipitation -
Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations
Authors: Chi Pui Pang
Lab. Invest., 2016-11-14;0(0):.
Species: Human
Sample Types: Cell Lysates
Applications: ICC, Western Blot -
HTRA1 promoter variant differentiates polypoidal choroidal vasculopathy from exudative age-related macular degeneration
Authors: Tsz Kin Ng
Sci Rep, 2016-06-24;6(0):28639.
Species: Human
Sample Types: Tissue Homogenates
Applications: Western Blot -
Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease.
Authors: Jo, Hakryul, Patterson, Victoria, Stoessel, Sean, Kuan, Chia-Yi, Hoh, Josephin
PLoS ONE, 2014-12-15;9(12):e115362.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Western Blot -
Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium.
Authors: Kumar, Sandeep, Berriochoa, Zachary, Ambati, Balamura, Fu, Yingbin
Invest Ophthalmol Vis Sci, 2014-05-22;55(6):3842-50.
Species: Mouse
Sample Types: Cell Lysates, Whole Tissue
Applications: IHC, Western Blot -
Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1.
Authors: Jacobo, Sarah Me, Deangelis, Margaret, Kim, Ivana K, Kazlauskas, Andrius
Mol Cell Biol, 2013-03-11;33(10):1976-90.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Immunoprecipitation -
Down-Regulation of HtrA1 Activates the Epithelial-Mesenchymal Transition and ATM DNA Damage Response Pathways.
Authors: Wang N, Eckert KA, Zomorrodi AR
PLoS ONE, 2012-06-26;7(6):e39446.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Matrix remodeling as stem cell recruitment event: a novel in vitro model for homing of human bone marrow stromal cells to the site of injury shows crucial role of extracellular collagen matrix.
Authors: Mauney J, Olsen BR, Volloch V
Matrix Biol., 2010-09-07;29(8):657-63.
Species: Human
Sample Types: Cell Lysates
Applications: Immunoprecipitation
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