Human IL-10 R beta Antibody
Human IL-10 R beta Antibody Summary
Accession # Q08334
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-10 R beta
IL-10 R beta, also known as IL-10 R2, mediates its biological activities via binding to a heteromeric receptor complex consisting of two distinct type II cytokine receptor subunits, the ligand binding IL-10 R alpha and the IL-10 R beta which does not bind IL-10 by itself but is required for signal transduction. The cDNA for human IL-10 R beta encodes a 325 amino acid (aa) residue type I transmembrane precursor protein with a 20 aa signal sequence, a 200 aa extracellular region, a 29 aa transmembrane segment and a short 76 aa cytoplasmic domain. Within the extracellular region, there are two 100 aa subdomains that resemble the constant region of immunoglobulins. This structural motif is responsible for the alternative designation of IL-10 R beta as CRF2-4 (the 4th member of the cytokine receptor family class II/2). Human and mouse IL-10 R beta share approximately 69% aa sequence identity. Binding of the non-covalent IL-10 dimer to two IL-10 R alpha chains recruits two IL‑10 R beta chains resulting in the activation and phosphorylation of the signaling cascade involving JAK1, TYK2, and STAT3. IL-10 R beta is expressed ubiquitously. IL‑10 R beta is also a component of the IL-22 receptor complex consisting of the IL-10 R beta chain and IL-22 R, another type II cytokine receptor family member.
- Donnelly, R.P. et al. (2004) J. Leukoc. Biol. 76:314.
- Donnelly, R.P. et al. (1999) J. Interferon Cytokine Res. 19:563.
- Kotenko, S.V. et al. (2000) J. Biol. Chem. 276:2725.
- Liu, Y. et al. (1994) J. Immunol. 152:1821.
- Lutfalla, G. et al. (1993) Genomics 16:366.
- Kotenko, S.V. et al. (1997) EMBO J. 16:5894.
No product specific FAQs exist for this product, however you mayView all Antibody FAQs
Reviews for Human IL-10 R beta Antibody
There are currently no reviews for this product. Be the first to review Human IL-10 R beta Antibody and earn rewards!
Have you used Human IL-10 R beta Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image