Human IL-13 R alpha 2 Antibody

Catalog # Availability Size / Price Qty
MAB6141-SP
MAB6141-100
MAB6141-500
Product Details
Citations (2)
FAQs
Supplemental Products
Reviews (1)

Human IL-13 R alpha 2 Antibody Summary

Species Reactivity
Human
Specificity
Detects human IL-13 R alpha 2 in ELISAs. In sandwich ELISAs, no cross-reactivity or interference was observed with recombinant human (rh) IL-4 R, rhIL-5 R alpha, rhIL‑9 R, rhIL‑13, rhIL-13 R alpha 1, recombinant mouse (rm) IL-13, rmIL-13 R alpha 1, or rmIL-13 R alpha 2.
Source
Monoclonal Mouse IgG1 Clone # 83807
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human IL‑13 R alpha 2
Cys22-Leu342
Accession # Q14627
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample

Human IL-13 R alpha 2 Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Human IL‑13 R alpha 2 Biotinylated Antibody (Catalog # BAF614)

Standard: Recombinant Human IL-13 R alpha 2 Fc Chimera (NS0), CF (Catalog # 614-INS)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Availability
Size / Price
Qty
RB01
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-13 R alpha 2

Two type I membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with high affinity. The lower affinity IL-13 binding protein is now referred to as IL-13 R alpha 1 and is also known as CD213a. IL-13 R alpha 1 combines with IL-4 R alpha to form a high affinity receptor complex capable of transducing an IL-13-dependent proliferative signal. The higher affinity IL-13 binding protein, now referred to as IL-13 R alpha 2, does not induce a signal and acts as a decoy receptor (1, 2).

References
  1. Wood, N. et al. (2003) J. Exp. Med. 197:703.
  2. Kelly-Welch, A. et al. (2003) Science 300:1527.
Long Name
Interleukin 13 Receptor alpha 2
Entrez Gene IDs
3598 (Human); 16165 (Mouse)
Alternate Names
cancer/testis antigen 19; CD213a2 antigen; CD213a2; CT19; IL-13 R alpha 2; IL-13 receptor subunit alpha-2; IL13BP; IL13R alpha 2; IL-13R subunit alpha-2; IL13R; IL-13R; IL13RA2; IL-13Ra2; IL-13R-alpha-2; interleukin 13 binding protein; interleukin 13 receptor alpha 2 chain; interleukin 13 receptor, alpha 2; interleukin-13 receptor subunit alpha-2; Interleukin-13-binding protein

Product Datasheets

Citations for Human IL-13 R alpha 2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy.
    Authors: Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK
    Cancer, 2006;107(6):1407-18.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Development
  2. Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients.
    Authors: Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S
    Mucosal Immunol, 0;5(2):140-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

FAQs

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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

Reviews for Human IL-13 R alpha 2 Antibody

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Human IL‑13 R alpha 2 Antibody
By Anonymous on 11/03/2017
Application: Flow Sample Tested: HEK293 human embryonic kidney cell line Species: Human