Human IL-20R alpha Antibody
Human IL-20R alpha Antibody Summary
Accession # Q9UHF4
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
IL‑20 R alpha in Human Skin. IL-20 Ra was detected in immersion fixed paraffin-embedded sections of human skin using 8 µg/mL Mouse Anti-Human IL-20 Ra Monoclonal Antibody (Catalog # MAB11761) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counter-stained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-20R alpha
IL-20 receptor alpha (IL-20 R alpha ), also named IL-20 R1, CRF2-8, and ZCYTOR7, belongs to the class II cytokine receptor family, which includes 12 members. These receptors are characterized by the patterns of conserved amino acid (aa) residues in their extracellular domains, which are composed of tandem fibronectin type III domains (1). Class II cytokine receptors form heterodimeric signaling receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions (1).
The gene for human IL-20 R alpha is mapped to chromosome 6 and encodes a 553 aa glycoprotein with a 29 aa signal peptide, a 221 aa extracellular domain, a 24 aa transmembrane region and a 279 aa intracellular domain (2). IL-20 R alpha is widely expressed and is detected at high levels in multiple tissues including skin, testis, heart, placenta, salivary gland and prostate gland (1). The expression of IL-20 R alpha, together with that of IL-20 R beta, is upregulated in psoriatic skin lesions on keratinocytes, immune cells, and endothelial cells (1, 2).
IL-20 R alpha heterodimerizes with IL-20 R beta to form the functional receptor that mediates IL-19, IL-20 and IL-24 signals (3, 4). IL-20 R alpha also heterodimerizes with IL-10 R beta to form the functional receptor complex for IL-26 (5). Binding of these IL-10 family class II cytokines to their functional receptors induces activation of the JAK-STAT signal transduction pathway. At low ligand concentrations, STAT3 has been shown to be the predominant STAT proteins activated through either complexes (3‑5).
- Kotenko, S.V. (2003) Cytokine & Growth Factor Reviews 13:223.
- Xie, M.H. et al. (2000) J. Biol. Chem. 275:31335.
- Dumoutier, L. et al. (2001) J. Immunol. 167:3534.
- Parrish-Novak, J. et al. (2002) J. Biol. Chem. 277:47517s.
- Sheikh. F. et al. (2004) J. Immunol. 172:2006.
Citations for Human IL-20R alpha Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
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Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis
Authors: Fries, A;Saidoune, F;Kuonen, F;Dupanloup, I;Fournier, N;Guerra de Souza, AC;Haniffa, M;Ma, F;Gudjonsson, JE;Roesner, L;Li, Y;Werfel, T;Conrad, C;Gottardo, R;Modlin, RL;Di Domizio, J;Gilliet, M;
Sample Types: Whole Cells
Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma
Authors: YS Chiu, CH Hsing, CF Li, CY Lee, YH Hsu, MS Chang
Sci Rep, 2017-12-14;7(1):17609.
Sample Types: Whole Cells
Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis.
Authors: Hsu YH, Li HH, Hsieh MY, Liu MF, Huang KY, Chin LS, Chen PC, Cheng HH, Chang MS
Arthritis Rheum., 2006-09-01;54(9):2722-33.
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-P
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