Human LAP (TGF-beta 1) Antibody
Human LAP (TGF-beta 1) Antibody Summary
Accession # P01137
Human LAP TGF-beta 1 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: LAP (TGF-beta 1)
The TGF-beta family includes several related proteins (70 - 80% sequence homology) from mammalian, avian or Xenopus systems that are now designated TGF-beta 1, TGF-beta 2, TGF-beta 1.2, TGF-beta 3, TGF-beta 4, and TGF-beta 5. These proteins are secreted by cells in the form of an inactive complex, referred to as Latent TGF-beta, that consists of TGF-beta associated non-covalently with a Latency-associated peptide (LAP). These two proteins are synthesized as a single pro-peptide that is cleaved in a post Golgi compartment prior to secretion. Different TGF-beta family members are naturally associated with their own distinct LAPs.
Citation for Human LAP (TGF-beta 1) Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2.
Authors: Paliwal S, Shi J, Dhru U, Zhou Y, Schuger L
Biochem. Biophys. Res. Commun., 2004;315(4):1104-9.
Sample Types: Cell Lysates
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