Human/Mouse BCAP Antibody Summary
Accession # Q6ZUJ8
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Human/Mouse BCAP by Western Blot. Western blot shows lysates of MO7e human megakaryocytic leukemic cell line and L1.2 mouse pro-B cell line. PVDF membrane was probed with 0.5 µg/mL of Human/Mouse BCAP Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4857) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for BCAP at approximately 100 kDa (as indicated). This experiment was conducted using Immunoblot Buffer Group 1.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
BCAP (B-cell adaptor for phosphoinositide 3-kinase (PI3K)) participates in linking the B cell antigen receptor (BCR) with the PI3K pathway. Tyrosine phosphorylation of BCAP by BCR-associated protein tyrosine kinases, such as Syk and Btk, generates binding sites for the p85 subunit of PI3K, resulting in activation of the PI3K pathway. Human and mouse BCAP contain 3 YXXM SH2 binding motifs for interaction with PI3K.
Citations for Human/Mouse BCAP Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain
Authors: JU Lauenstein, MJ Scherm, A Udgata, MC Moncrieffe, DI Fisher, NJ Gay
J. Immunol., 2020;0(0):.
Species: Escherichia coli
Sample Types: Whole Cells
Phosphorylation of the multi functional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2
Authors: JU Lauenstein, A Udgata, A Bartram, D De Sutter, DI Fisher, S Halabi, S Eyckerman, NJ Gay
J. Biol. Chem., 2019;0(0):.
Sample Types: Protein
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