Human/Mouse MMP-24/MT5-MMP Antibody Summary
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Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
MMP‑24 in Human Brain. MMP-24 was detected in immersion fixed paraffin-embedded sections of human brain using Rabbit Anti-Human/Mouse MMP-24/MT5-MMP Polyclonal Antibody (Catalog # AB924) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rabbit HRP-AEC Cell & Tissue Staining Kit (red; Catalog # CTS006) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of neurons. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
MMP‑24 in Human Astro-cytoma. MMP-24 was detected in immersion fixed paraffin-embedded sections of human brain (astrocytoma) using Rabbit Anti-Human/Mouse MMP-24/ MT5-MMP Polyclonal Antibody (Catalog # AB924) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rabbit HRP-AEC Cell & Tissue Staining Kit (red; Catalog # CTS006) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of cancer cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).
Citation for Human/Mouse MMP-24/MT5-MMP Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Neoplastic Cells are the Major Source of MT-MMPs in IDH1-Mutant Glioma, Thus Enhancing Tumor-Cell Intrinsic Brain Infiltration
Authors: I Thome, R Lacle, A Vo beta, G Bortolussi, G Pantazis, A Schmidt, C Conrad, R Jacob, N Timmesfeld, JW Bartsch, A Pagenstech
Cancers (Basel), 2020;12(9):.
Sample Types: Whole Cells
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