Human/Mouse Norrin Antibody

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Product Details
Citations (2)
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Reviews (1)

Human/Mouse Norrin Antibody Summary

Species Reactivity
Human, Mouse
Detects human and mouse Norrin in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross-reactivity with recombinant mouse Norrin is observed.
Monoclonal Mouse IgG1 Clone # 343711
Protein A or G purified from hybridoma culture supernatant
E. coli-derived recombinant human Norrin
Accession # Q00604
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
1 µg/mL
Recombinant Human Norrin (Catalog # 3014-NR) under reducing conditions only
Recombinant Mouse Norrin (Catalog # 3497-NR)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Norrin

Norrin, also known as Norrie Disease Protein, is a secreted protein that has a C-terminal cysteine-knot motif. Although Norrin is unrelated to Wnt family proteins, it is a Frizzled-4-specific ligand that activates the canonical Wnt pathway through Frizzled-4 and LRP5 (LDL receptor-related protein). Mutations in Norrin are associated with Norrie disease and X-linked familial exudative vitroretinopathy. The amino acid sequence of human Norrin is 100% and 94% identical to rhesus macaque and mouse Norrin, respectively.

Entrez Gene IDs
4693 (Human)
Alternate Names
EVR2; exudative vitreoretinopathy 2 (X-linked); FEVR; ND; NDP; Norrie disease (pseudoglioma); Norrie disease protein; Norrin; X-linked exudative vitreoretinopathy 2 protein

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Citations for Human/Mouse Norrin Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation
    Authors: GA Weiner, SH Shah, CM Angelopoul, AB Bartakova, RS Pulido, A Murphy, E Nudleman, R Daneman, JL Goldberg
    Nat Commun, 2019;10(1):2477.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  2. Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer's disease
    Authors: DC Hondius, KN Eigenhuis, THJ Morrema, RC van der Sc, P van Nierop, M Bugiani, KW Li, JJM Hoozemans, AB Smit, AJM Rozemuller
    Acta Neuropathol Commun, 2018;6(1):46.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot


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Human/Mouse Norrin Antibody
By Anonymous on 04/07/2021
Application: WB Sample Tested: Purified mouse Ndp protein Species: Mouse

used at 1ug/mL in 5% Blocking Solution (Biorad) overnight at 4C