Human/Mouse STAT5a/b ExactaChIP Chromatin IP Kit

Human/Mouse STAT5a/b ExactaChIP Chromatin IP Kit Summary

Specifications

Product Datasheets

Background: STAT5a/b

Signal transduction and activator of transcription 5 (STAT5) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL22, IL6, IFN-α). STAT5 has two isoforms (A and B) that share 93% amino acid identity and bind the DNA consensus site TTCN3GAA. STAT5 mediates cytokine signaling by acting as a signal transducer in the cytoplasm and, upon phosphorylation, translocates to the nucleus and activates transcription of specific genes. STAT5 is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation and survival.

Related Research Areas

• Apoptosis Transcription Factors and Regulators
• Cancer Stem Cell Transcription Factors
• Common gamma Chain Receptor Family
• Dendritic Cell Development
• Hematopoietic Stem Cell Markers
• IL-10 and Interferon Family Regulators
• IL-10 Family
• IL-12 Family
• Immunoglobulin-Like Domain Transcription Factors
• Interferons
• Intracellular Signaling Molecules in Angiogenesis
• Jak and STAT Proteins
• PDGF Family
• STAT
• Th2 Cells
• Transcription Factors in the Akt Pathway