Human MUC-19 Antibody

  
  • Species Reactivity
    Human
  • Specificity
    Detects human MUC-19 in direct ELISAs.
  • Source
    Monoclonal Mouse IgG1 Clone # 876013
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    E. coli-derived recombinant human MUC-19
    Lys5606-Gly5767
    Accession # Q7Z5P9
  • Formulation
    Supplied as a 0.2 μm filtered solution in PBS. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
  • Label
    Unconjugated
Applications
  •  
    Recommended
    Concentration
    Sample
  • Immunohistochemistry
    8-25 µg/mL
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Immunohistochemistry
MUC‑19 in Human Salivary Gland. MUC‑19 was detected in immersion fixed paraffin-embedded sections of human salivary gland using Mouse Anti-Human MUC‑19 Monoclonal Antibody (Catalog # MAB8245) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to mucosal cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Preparation and Storage
  • Shipping
    The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
  • Stability & Storage
    Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C, as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after opening.
    • 6 months, -20 to -70 °C under sterile conditions after opening.
Background: MUC-19

MUC-19 is a 6,254 amino acid member of the Mucin family of gel-forming glycoproteins.  MUC-19 is expressed in corneal epithelial cells in the eye, conjuctival goblet and epithelial cells and lacrimal gland cells as well as by mucous cells of the submandibular gland and submucosal gland of the trachea.  MUC-19 expression is reduced in patients with Sjogren syndrome (1,2). In a middle ear model of inflammatory response, MUC-19 is up-regulated in epithelial cells by exposure to cytokines including TNF-alpha, IL-1 beta, IL-5 and IL-8 (3).

 

  • References:
    1. Yu, D. et al. (2008) Exp Eye Res. 86 :403.
    2. Chen, Y. et al. (2004) Am J Respir Cell Mol Biol 30:155.
    3. Kerschner, J. et al. (2009) Glycoconj J. 26:1275.
  • Long Name:
    Mucin 19, Oligomeric
  • Entrez Gene IDs:
    283463 (Human)
  • Alternate Names:
    MUC19; MUC-19
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