Human NgR2/NgRH1 Antibody

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Product Details
Citations (3)
Supplemental Products

Human NgR2/NgRH1 Antibody Summary

Species Reactivity
Detects human NgR2/NgRH1 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant human (rh) NgR and rhNgRH2 is observed.
Polyclonal Goat IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant human NgR2/NgRH1
Accession # Q86UN3
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human NgR2/NgRH1

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: NgR2/NgRH1

NgR2, also known as reticulon 4 receptor-like 2 and NgR2, is a 60 kDa glycosylphosphatidylinositol-anchored protein that is expressed primarily in the brain. It contains eight leucine-rich repeats that are flanked by cysteine-rich sequences at both the N- as well as the C-terminus. Membrane-anchored NgR2 can be solubilized through the action of phospholipase or an unidentified MT-MMP to generate a 46 kDa soluble receptor. Mature human NgR2 shares 48% aa sequence identity with human NgRH2. It also shares 96% aa sequence identity with mouse and rat mature NgR2.

Long Name
Nogo-66 Receptor-related Protein 2/Nogo-66 Receptor Homolog 1/Reticulon-4 Receptor-like 2
Entrez Gene IDs
349667 (Human); 269295 (Mouse)
Alternate Names
NgR2; NgRH1; reticulon 4 receptor-like 2; RTN4RL2

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Citations for Human NgR2/NgRH1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. The NOGO receptor NgR2, a novel alphaVbeta3 integrin effector, induces neuroendocrine differentiation in prostate cancer
    Authors: F Quaglia, SR Krishn, K Sossey-Ala, PS Rana, E Pluskota, PH Park, CD Shields, S Lin, P McCue, AV Kossenkov, Y Wang, DW Goodrich, SY Ku, H Beltran, WK Kelly, E Corey, M Klose, C Bandtlow, Q Liu, DC Altieri, EF Plow, LR Languino
    Scientific Reports, 2022-11-07;12(1):18879.
    Species: Human
    Sample Types: Protein
    Applications: Western Blot
  2. Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists.
    Authors: Williams G, Wood A, Williams EJ, Gao Y, Mercado ML, Katz A, Joseph-McCarthy D, Bates B, Ling HP, Aulabaugh A, Zaccardi J, Xie Y, Pangalos MN, Walsh FS, Doherty P
    J. Biol. Chem., 2008-04-14;283(24):16641-52.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  3. A role for Nogo receptor in macrophage clearance from injured peripheral nerve.
    Authors: Fry EJ, Ho C, David S
    Neuron, 2007-03-01;53(5):649-62.
    Species: Rat
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Slot Blot


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Isotype Controls

Reconstitution Buffers

Secondary Antibodies

Goat IgG (H+L) Antibody


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