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Human Protein S/PROS1 Antibody

Catalog #: MAB4036
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB4036
MAB4036-SP

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Detection of Human Protein S/PROS1 by Western Blot.
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Citations (2)
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Human Protein S/PROS1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human Protein S in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross‑react with recombinant mouse Protein S.
Source
Monoclonal Mouse IgG1 Clone # 391609
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Protein S
Ala42-Trp670
Accession # P07225
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.5 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human Protein S/PROS1 antibody by Western Blot. View Larger

Detection of Human Protein S/PROS1 by Western Blot. Western blot shows human plasma. PVDF membrane was probed with 0.5 µg/mL of Mouse Anti-Human Protein S/PROS1 Monoclonal Antibody (Catalog # MAB4036) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for Protein S/PROS1 at approximately 80 kDa (as indicated). This experiment was conducted under non-reducing conditions and using Immunoblot Buffer Group 1.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Protein S/PROS1

The PROS1 gene encodes Protein S (PS), a ~70 kDa vitamin-K dependent plasma glycoprotein mainly synthesized by human hepatocytes. PS is a non-enzymatic cofactor in the degradation of coagulation factors Va and VIIIa and thus plays an anticoagulant role. Approximately 60% circulates in complex with C4b-binding protein. Free PS is a mixture of monomers and multimers. The 652 aa PS proprotein is heavily modified with 11 carboxyglutamates, one hydroxyaspartate, disulfides and glycosylation. Human Protein S shows 80% aa identity with mouse Protein S.

Entrez Gene IDs
5627 (Human); 19128 (Mouse); 81750 (Rat)
Alternate Names
EC 3.4.21; PROS; PROS1; protein S (alpha); Protein S; protein Sa; PS21; PS22; PS23; PS24; PS25; PSA; vitamin K-dependent plasma protein S; vitamin K-dependent protein S

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Citations for Human Protein S/PROS1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Alcohol and HIV-Derived Hepatocyte Apoptotic Bodies Induce Hepatic Stellate Cell Activation
    Authors: M New-Aaron, RS Dagur, SS Koganti, M Ganesan, W Wang, E Makarov, M Ogunnaike, KK Kharbanda, LY Poluektova, NA Osna
    Biology, 2022-07-14;11(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  2. Human Placental Mesenchymal Stem/Stromal cells (pMSCs) inhibit agonist-induced platelet functions reducing atherosclerosis and thrombosis phenotypes
    Authors: A Al Subayyi, YS Basmaeil, R Alenzi, T Khatlani
    Journal of Cellular and Molecular Medicine, 2021-09-18;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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